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    Gpr85 G protein-coupled receptor 85 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 64020, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Gpr85provided by RGD
    Official Full Name
    G protein-coupled receptor 85provided by RGD
    Primary source
    RGD:71011
    See related
    EnsemblRapid:ENSRNOG00000024636 AllianceGenome:RGD:71011
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    SREB2; Srep2; PKrCx1
    Summary
    Predicted to enable G protein-coupled receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to be located in endoplasmic reticulum. Predicted to be active in plasma membrane. Orthologous to human GPR85 (G protein-coupled receptor 85). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 63.4) and Uterus (RPKM 16.1) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Gpr85 in Genome Data Viewer
    Location:
    4q22
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (43070194..43075662, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (42100138..42109584, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (40377705..40387147, complement)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene S-adenosylmethionine sensor upstream of mTORC1 Neighboring gene uncharacterized LOC120102155 Neighboring gene small integral membrane protein 30 like 1 Neighboring gene fatty acid-binding protein, heart-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. A conserved mRNA expression profile of SREB2 (GPR85) in adult human, monkey, and rat forebrain. Matsumoto M, et al. Brain Res Mol Brain Res, 2005 Jul 29. PMID 15893849
    2. The association of GPR85 with PSD-95-neuroligin complex and autism spectrum disorder: a molecular analysis. Fujita-Jimbo E, et al. Mol Autism, 2015. PMID 25780553, Free PMC Article
    3. An evolutionarily conserved G-protein coupled receptor family, SREB, expressed in the central nervous system. Matsumoto M, et al. Biochem Biophys Res Commun, 2000 Jun 7. PMID 10833454
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Clone Names

    • MGC105281

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    probable G-protein coupled receptor 85
    Names
    Super Conserved Receptor Expressed in Brain 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_022254.4 → NP_071590.1  probable G-protein coupled receptor 85

      See identical proteins and their annotated locations for NP_071590.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/Swiss-Prot
      P60895
      UniProtKB/TrEMBL
      A6IE06
      Conserved Domains (1) summary
      cd15218
      Location:21 → 350
      7tmA_SREB2_GPR85; super conserved receptor expressed in brain 2 (or GPR85), member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      43070194..43075662 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006236126.5 → XP_006236188.1  probable G-protein coupled receptor 85 isoform X1

      See identical proteins and their annotated locations for XP_006236188.1

      UniProtKB/Swiss-Prot
      P60895
      UniProtKB/TrEMBL
      A6IE06
      Related
      ENSRNOP00000031780.3, ENSRNOT00000039005.7
      Conserved Domains (1) summary
      cd15218
      Location:21 → 350
      7tmA_SREB2_GPR85; super conserved receptor expressed in brain 2 (or GPR85), member of the class A family of seven-transmembrane G protein-coupled receptors

    2. XM_006236124.5 → XP_006236186.1  probable G-protein coupled receptor 85 isoform X1

      See identical proteins and their annotated locations for XP_006236186.1

      UniProtKB/Swiss-Prot
      P60895
      UniProtKB/TrEMBL
      A6IE06
      Related
      ENSRNOP00000111229.1, ENSRNOT00000149013.1
      Conserved Domains (1) summary
      cd15218
      Location:21 → 350
      7tmA_SREB2_GPR85; super conserved receptor expressed in brain 2 (or GPR85), member of the class A family of seven-transmembrane G protein-coupled receptors

    3. XM_017592861.3 → XP_017448350.1  probable G-protein coupled receptor 85 isoform X1

      UniProtKB/Swiss-Prot
      P60895
      UniProtKB/TrEMBL
      A6IE06
      Related
      ENSRNOP00000112202.1, ENSRNOT00000167546.1
      Conserved Domains (1) summary
      cd15218
      Location:21 → 350
      7tmA_SREB2_GPR85; super conserved receptor expressed in brain 2 (or GPR85), member of the class A family of seven-transmembrane G protein-coupled receptors

    4. XM_017592860.3 → XP_017448349.1  probable G-protein coupled receptor 85 isoform X1

      UniProtKB/Swiss-Prot
      P60895
      UniProtKB/TrEMBL
      A6IE06
      Related
      ENSRNOP00000098842.1, ENSRNOT00000142999.1
      Conserved Domains (1) summary
      cd15218
      Location:21 → 350
      7tmA_SREB2_GPR85; super conserved receptor expressed in brain 2 (or GPR85), member of the class A family of seven-transmembrane G protein-coupled receptors
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P60895.1 GenPept UniProtKB/Swiss-Prot:P60895

    Gene LinkOut

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