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    Sh2d3c SH2 domain containing 3C [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362111, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Sh2d3cprovided by RGD
    Official Full Name
    SH2 domain containing 3Cprovided by RGD
    Primary source
    RGD:1307287
    See related
    EnsemblRapid:ENSRNOG00000054560 AllianceGenome:RGD:1307287
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    NSP3
    Summary
    Predicted to enable guanyl-nucleotide exchange factor activity and phosphotyrosine residue binding activity. Predicted to be involved in small GTPase-mediated signal transduction. Predicted to be located in cytosol. Orthologous to human SH2D3C (SH2 domain containing 3C). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 79.0), Lung (RPKM 74.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Sh2d3c in Genome Data Viewer
    Location:
    3p11
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (36408305..36444191)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (16010622..16046491)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (11756427..11793547)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene folylpolyglutamate synthase Neighboring gene cyclin-dependent kinase 9 Neighboring gene RNA, U6 small nuclear 899 Neighboring gene torsin family 2, member A Neighboring gene tetratricopeptide repeat domain 16 Neighboring gene cilia and flagella associated protein 157 Neighboring gene peptidyl-tRNA hydrolase 1 homolog

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Up-regulation of NSP3 by Oligomeric Aβ Accelerates Neuronal Death Through Cas-independent Rap1A Activation. Gomi F, et al. Neuroscience, 2018 Aug 21. PMID 29966723
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. NSP3 RNAi knock-down partially rescued amyloid-Beta-oligomer-treated neurons.
      Title: Up-regulation of NSP3 by Oligomeric Aβ Accelerates Neuronal Death Through Cas-independent Rap1A Activation.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphotyrosine residue binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in small GTPase-mediated signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    SH2 domain-containing protein 3C

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108579.1 → NP_001102049.1  SH2 domain-containing protein 3C

      See identical proteins and their annotated locations for NP_001102049.1

      Status: PROVISIONAL

      Source sequence(s)
      CH474001
      UniProtKB/TrEMBL
      A0A0G2JYH7, A0A8I6A5D5, A6JU82
      Related
      ENSRNOP00000088575.2, ENSRNOT00000113142.2
      Conserved Domains (2) summary
      cd10337
      Location:208 → 342
      SH2_BCAR3; Src homology 2 (SH2) domain in the Breast Cancer Anti-estrogen Resistance protein 3
      cl02485
      Location:578 → 755
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      36408305..36444191
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039105377.2 → XP_038961305.1  SH2 domain-containing protein 3C isoform X1

      UniProtKB/TrEMBL
      A0A8I6A5D5
      Conserved Domains (2) summary
      cd10337
      Location:136 → 270
      SH2_BCAR3; Src homology 2 (SH2) domain in the Breast Cancer Anti-estrogen Resistance protein 3
      cl02485
      Location:506 → 683
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...

    2. XM_008761759.4 → XP_008759981.1  SH2 domain-containing protein 3C isoform X2

      UniProtKB/TrEMBL
      A0A2Z5DT54, A0A8I5ZME7
      Related
      ENSRNOP00000078942.1, ENSRNOT00000110408.2
      Conserved Domains (2) summary
      cd10337
      Location:56 → 190
      SH2_BCAR3; Src homology 2 (SH2) domain in the Breast Cancer Anti-estrogen Resistance protein 3
      cl02485
      Location:426 → 603
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...

    3. XM_063284070.1 → XP_063140140.1  SH2 domain-containing protein 3C isoform X6

    4. XM_008761760.4 → XP_008759982.1  SH2 domain-containing protein 3C isoform X3

      UniProtKB/TrEMBL
      A0A2Z5DT54
      Conserved Domains (2) summary
      cd10337
      Location:55 → 189
      SH2_BCAR3; Src homology 2 (SH2) domain in the Breast Cancer Anti-estrogen Resistance protein 3
      cl02485
      Location:425 → 602
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...

    5. XM_017591882.3 → XP_017447371.1  SH2 domain-containing protein 3C isoform X4

      UniProtKB/TrEMBL
      A0A2Z5DT54

    6. XM_039105378.2 → XP_038961306.1  SH2 domain-containing protein 3C isoform X5

      UniProtKB/TrEMBL
      A0A8I6GAN0
      Conserved Domains (2) summary
      cd10337
      Location:46 → 180
      SH2_BCAR3; Src homology 2 (SH2) domain in the Breast Cancer Anti-estrogen Resistance protein 3
      cl02485
      Location:416 → 593
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
    Nucleotide Protein Strain
    Heading Accession and Version

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