Neto2 neuropilin and tolloid like 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Neto2provided by RGD
Official Full Name: neuropilin and tolloid like 2provided by RGD
Primary source: RGD:1305310
See related: EnsemblRapid:ENSRNOG00000016245 AllianceGenome:RGD:1305310
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable ionotropic glutamate receptor binding activity. Involved in neurotransmitter receptor localization to postsynaptic specialization membrane and regulation of neurotransmitter receptor localization to postsynaptic specialization membrane. Is active in glutamatergic synapse. Orthologous to human NETO2 (neuropilin and tolloid like 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 209.2), Kidney (RPKM 66.5) and 5 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 19p11

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	19	NC_086037.1 (37517518..37588961)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	19	NC_051354.1 (21344299..21415524)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	19	NC_005118.4 (22450579..22486530)

Chromosome 19 - NC_086037.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

NETO2-GluK2 interaction contributes to postoperative pain hypersensitivity through inducing PKCgamma activation and synaptic incorporation of AMPA receptor GluR1 subunits in rat dorsal horn.
Title: NETO2-GluK2 interaction contributes to postoperative pain hypersensitivity through inducing PKCγ activation and synaptic incorporation of AMPA receptor GluR1 subunits in rat dorsal horn.
Neto1 and Neto2 differentially regulate GluK2 fast gating kinetics
Title: Neto proteins regulate gating of the kainate-type glutamate receptor GluK2 through two binding sites.
GluK2 surface and synaptic expression are independent on the auxiliary subunits Neto1 and Neto2. In the CA1 hippocampal pyramidal cell, GluK2, in contrast to GluK1, traffics to the neuronal surface and synapse efficiently and the auxiliary subunits rNeto1 and mNeto2 caused no further enhancement of these two trafficking processes.
Title: Amino-terminal domains of kainate receptors determine the differential dependence on Neto auxiliary subunits for trafficking.
Data suggest Camk2a and Prkaca exhibit substrate specificity that includes phosphorylation of Neto2 at Ser409 in C-terminal domain; Neto2 Ser409 phosphorylation inhibits synaptic targeting of Gluk1. (Camk2a = calcium-calmodulin-dependent protein kinase II, alpha subunit; Prkaca = cAMP-dependent protein kinase, alpha-catalytic subunit; Neto2 = neuropilin and tolloid-like protein 2; Gluk1 = kainate receptor Gluk1)
Title: Phosphorylation of the kainate receptor (KAR) auxiliary subunit Neto2 at serine 409 regulates synaptic targeting of the KAR subunit GluK1.
NETO2 slows the desensitization rate of glutamate K2 kainate (GluK2a) receptors, promotes plasma membrane localization of receptors in hippocampal neurons, and targets GluK1-containing receptors to synapses.
Title: Synaptic targeting and functional modulation of GluK1 kainate receptors by the auxiliary neuropilin and tolloid-like (NETO) proteins.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ionotropic glutamate receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables ionotropic glutamate receptor binding	IEA Inferred from Electronic Annotation more info
enables ionotropic glutamate receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in neurotransmitter receptor localization to postsynaptic specialization membrane	IDA Inferred from Direct Assay more info	PubMed
involved_in neurotransmitter receptor localization to postsynaptic specialization membrane	IMP Inferred from Mutant Phenotype more info	PubMed
NOT acts_upstream_of_or_within positive regulation of excitatory postsynaptic potential	ISO Inferred from Sequence Orthology more info
involved_in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
located_in glutamatergic synapse	IEA Inferred from Electronic Annotation more info
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in postsynaptic density	IBA Inferred from Biological aspect of Ancestor more info
located_in postsynaptic density	ISO Inferred from Sequence Orthology more info
located_in postsynaptic density membrane	IEA Inferred from Electronic Annotation more info
is_active_in postsynaptic density membrane	ISO Inferred from Sequence Orthology more info
located_in synapse	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: neuropilin and tolloid-like protein 2

Names: brain-specific transmembrane protein containing 2 CUB and 1 LDL-receptor class A domains protein 2; neuropilin (NRP) and tolloid (TLL)-like 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001107417.3 → NP_001100887.2 neuropilin and tolloid-like protein 2 precursor

See identical proteins and their annotated locations for NP_001100887.2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000019

UniProtKB/Swiss-Prot

C6K2K4

UniProtKB/TrEMBL

F1MA16

Related

ENSRNOP00000021739.6, ENSRNOT00000021739.8

Conserved Domains (2) summary

cd00041
Location:45 → 158

CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

cd00112
Location:297 → 331

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086037.1 Reference GRCr8

Range

37517518..37588961

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039097726.2 → XP_038953654.1 neuropilin and tolloid-like protein 2 isoform X1

UniProtKB/TrEMBL

F1MA16

Conserved Domains (2) summary

cd00041
Location:45 → 158

CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

cd00112
Location:290 → 324

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...