Ptges3l prostaglandin E synthase 3 like [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ptges3lprovided by RGD
Official Full Name: prostaglandin E synthase 3 likeprovided by RGD
Primary source: RGD:9413039
See related: EnsemblRapid:ENSRNOG00000050347 AllianceGenome:RGD:9413039
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable Hsp90 protein binding activity and protein-folding chaperone binding activity. Predicted to be located in cytoplasm. Orthologous to human PTGES3L (prostaglandin E synthase 3 like). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Muscle (RPKM 119.2), Heart (RPKM 88.1) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q31

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (86854268..86861568, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (86354019..86361318, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (89331368..89338644, complement)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables Hsp90 protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables Hsp90 protein binding	IEA Inferred from Electronic Annotation more info
enables protein-folding chaperone binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein-folding chaperone binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in chaperone-mediated protein complex assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein folding	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: putative protein PTGES3L

Names: alanyl-tRNA synthetase domain containing 1-like; prostaglandin E synthase 3 (cytosolic)-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001399462.1 → NP_001386391.1 putative protein PTGES3L

Status: VALIDATED

Source sequence(s)

JAXUCZ010000010

UniProtKB/TrEMBL

A0A8I6AJ40, A6HJB6

Conserved Domains (1) summary

cd00237
Location:5 → 110

p23; p23 binds heat shock protein (Hsp)90 and participates in the folding of a number of Hsp90 clients, including the progesterone receptor. p23 also has a passive chaperoning activity and in addition may participate in prostaglandin synthesis.

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

86854268..86861568 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063268252.1 → XP_063124322.1 putative protein PTGES3L isoform X1

UniProtKB/TrEMBL

A6HJB5, M0R7Z4

Related

ENSRNOP00000065582.3, ENSRNOT00000073923.4
XM_008768222.4 → XP_008766444.1 putative protein PTGES3L isoform X3

See identical proteins and their annotated locations for XP_008766444.1

Conserved Domains (1) summary

cl00175
Location:1 → 92

alpha-crystallin-Hsps_p23-like; alpha-crystallin domain (ACD) found in alpha-crystallin-type small heat shock proteins, and a similar domain found in p23 (a cochaperone for Hsp90) and in other p23-like proteins.
XM_039087748.2 → XP_038943676.1 putative protein PTGES3L isoform X4

Conserved Domains (1) summary

cd00237
Location:35 → 140

p23; p23 binds heat shock protein (Hsp)90 and participates in the folding of a number of Hsp90 clients, including the progesterone receptor. p23 also has a passive chaperoning activity and in addition may participate in prostaglandin synthesis.
XM_008768220.4 → XP_008766442.1 putative protein PTGES3L isoform X2

See identical proteins and their annotated locations for XP_008766442.1

UniProtKB/TrEMBL

A0A8I5ZS02

Related

ENSRNOP00000093004.2, ENSRNOT00000106212.2

Conserved Domains (1) summary

cd00237
Location:35 → 140

p23; p23 binds heat shock protein (Hsp)90 and participates in the folding of a number of Hsp90 clients, including the progesterone receptor. p23 also has a passive chaperoning activity and in addition may participate in prostaglandin synthesis.