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    Ecel1 endothelin converting enzyme-like 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 60417, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ecel1provided by RGD
    Official Full Name
    endothelin converting enzyme-like 1provided by RGD
    Primary source
    RGD:61806
    See related
    EnsemblRapid:ENSRNOG00000019447 AllianceGenome:RGD:61806
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Dine
    Summary
    Predicted to enable metalloendopeptidase activity. Involved in intracellular signal transduction and neuropeptide signaling pathway. Predicted to be located in membrane. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in distal arthrogryposis type 5D. Orthologous to human ECEL1 (endothelin converting enzyme like 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 7.0), Testes (RPKM 0.7) and 2 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ecel1 in Genome Data Viewer
    Location:
    9q35
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (95267417..95276508, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (87819516..87829154, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (94238568..94252484, complement)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene U6 spliceosomal RNA Neighboring gene alkaline phosphatase 3, intestine, not Mn requiring Neighboring gene uncharacterized LOC134480403 Neighboring gene serine protease 56 Neighboring gene cholinergic receptor nicotinic delta subunit

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Localization and ontogeny of damage-induced neuronal endopeptidase mRNA-expressing neurons in the rat nervous system. Nagata K, et al. Neuroscience, 2006 Aug 11. PMID 16675137
    2. Damage-induced neuronal endopeptidase (DINE/ECEL) expression is regulated by leukemia inhibitory factor and deprivation of nerve growth factor in rat sensory ganglia after nerve injury. Kato R, et al. J Neurosci, 2002 Nov 1. PMID 12417666, Free PMC Article
    3. Damage-induced neuronal endopeptidase (DINE) is a unique metallopeptidase expressed in response to neuronal damage and activates superoxide scavengers. Kiryu-Seo S, et al. Proc Natl Acad Sci U S A, 2000 Apr 11. PMID 10759559, Free PMC Article
    4. Neonatal lethality in mice deficient in XCE, a novel member of the endothelin-converting enzyme and neutral endopeptidase family. Schweizer A, et al. J Biol Chem, 1999 Jul 16. PMID 10400672
    5. XCE, a new member of the endothelin-converting enzyme and neutral endopeptidase family, is preferentially expressed in the CNS. Valdenaire O, et al. Brain Res Mol Brain Res, 1999 Feb 5. PMID 9931490

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Sp1 recruits ATF3, c-Jun, and STAT3 to obtain the requisite synergistic effect in neuronal injury through DINE neuronal injury-inducible gene
      Title: Neuronal injury-inducible gene is synergistically regulated by ATF3, c-Jun, and STAT3 through the interaction with Sp1 in damaged neurons.
    2. Damage-induced neuronal endopeptidase play an important role in embryonic neural development, in particular in peripheral ganglia derived from the neural crest, and in some neurons from the basal plate such as the hypothalamus and cranial motor neurons.
      Title: Localization and ontogeny of damage-induced neuronal endopeptidase mRNA-expressing neurons in the rat nervous system.
    3. DINE gene expression is regulated separately by both LIF and NGF deprivation, and this regulation pattern is similar to that of galanin gene expression after nerve injury
      Title: Damage-induced neuronal endopeptidase (DINE/ECEL) expression is regulated by leukemia inhibitory factor and deprivation of nerve growth factor in rat sensory ganglia after nerve injury.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metalloendopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metalloendopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metalloendopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metalloendopeptidase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in intracellular signal transduction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in neuropeptide signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in respiratory system process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in respiratory system process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in respiratory system process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    endothelin-converting enzyme-like 1
    Names
    damage-induced neuronal endopeptidase
    metallopeptidase
    xce protein
    NP_068544.2
    XP_017452104.1
    XP_063123735.1
    XP_063123736.1
    XP_063123737.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_021776.3 → NP_068544.2  endothelin-converting enzyme-like 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/Swiss-Prot
      Q9JHL3, Q9Z192
      UniProtKB/TrEMBL
      A6JWK8, D4AD32
      Related
      ENSRNOP00000095212.1, ENSRNOT00000095466.2
      Conserved Domains (1) summary
      cd08662
      Location:121 → 773
      M13; Peptidase family M13 includes neprilysin and endothelin-converting enzyme I

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      95267417..95276508 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063267666.1 → XP_063123736.1  endothelin-converting enzyme-like 1 isoform X1

      UniProtKB/Swiss-Prot
      Q9JHL3, Q9Z192

    2. XM_063267665.1 → XP_063123735.1  endothelin-converting enzyme-like 1 isoform X1

      UniProtKB/Swiss-Prot
      Q9JHL3, Q9Z192

    3. XM_017596615.3 → XP_017452104.1  endothelin-converting enzyme-like 1 isoform X2

      UniProtKB/Swiss-Prot
      Q9JHL3, Q9Z192
      UniProtKB/TrEMBL
      A6JWK8, D4AD32
      Conserved Domains (1) summary
      cd08662
      Location:121 → 773
      M13; Peptidase family M13 includes neprilysin and endothelin-converting enzyme I

    4. XM_063267667.1 → XP_063123737.1  endothelin-converting enzyme-like 1 isoform X1

      UniProtKB/Swiss-Prot
      Q9JHL3, Q9Z192
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9JHL3.1 GenPept UniProtKB/Swiss-Prot:Q9JHL3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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