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    Kalrn kalirin, RhoGEF kinase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 84009, updated on 9-Dec-2024

    Summary

    Official Symbol
    Kalrnprovided by RGD
    Official Full Name
    kalirin, RhoGEF kinaseprovided by RGD
    Primary source
    RGD:621865
    See related
    EnsemblRapid:ENSRNOG00000001706 EnsemblRapid:ENSRNOG00000072161 AllianceGenome:RGD:621865
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Duo; Hapip; Kalirin
    Summary
    Enables enzyme binding activity. Involved in several processes, including regulation of dendrite development; regulation of modification of postsynaptic actin cytoskeleton; and regulation of neurotransmitter receptor localization to postsynaptic specialization membrane. Located in neuronal cell body and perinuclear region of cytoplasm. Is active in glutamatergic synapse; postsynaptic density; and presynapse. Human ortholog(s) of this gene implicated in cerebral atherosclerosis; cerebral infarction; and coronary artery disease. Orthologous to human KALRN (kalirin RhoGEF kinase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 203.9), Heart (RPKM 67.3) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Kalrn in Genome Data Viewer
    Location:
    11q22
    Exon count:
    67
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (79703345..80309210)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (66198155..66803166)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (69484293..70025682)

    Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120095665 Neighboring gene coiled-coil domain containing 14 Neighboring gene rhophilin associated tail protein 1 Neighboring gene G2/mitotic-specific cyclin-B1-like Neighboring gene uncharacterized LOC120095553 Neighboring gene uncharacterized LOC120095552 Neighboring gene uncharacterized LOC134481079 Neighboring gene uridine monophosphate synthetase Neighboring gene integrin subunit beta 5

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Items 1 - 25 of 30
    Function Evidence Code Pubs
    enables 3-phosphoinositide-dependent protein kinase activity  
    enables AMP-activated protein kinase activity  
    enables ATP binding  
    enables DNA-dependent protein kinase activity  
    enables Rho-dependent protein serine/threonine kinase activity  
    enables enzyme binding PubMed 
    enables eukaryotic translation initiation factor 2alpha kinase activity  
    enables guanyl-nucleotide exchange factor activity  
    enables guanyl-nucleotide exchange factor activity  
    enables guanyl-nucleotide exchange factor activity  
    enables guanyl-nucleotide exchange factor activity PubMed 
    enables histone H2AS1 kinase activity  
    enables histone H2AS121 kinase activity  
    enables histone H2AT120 kinase activity  
    enables histone H2AXS139 kinase activity  
    enables histone H2BS14 kinase activity  
    enables histone H2BS36 kinase activity  
    enables histone H3S10 kinase activity  
    enables histone H3S28 kinase activity  
    enables histone H3S57 kinase activity  
    enables histone H3T11 kinase activity  
    enables histone H3T3 kinase activity  
    enables histone H3T45 kinase activity  
    enables histone H3T6 kinase activity  
    enables histone H4S1 kinase activity  
    enables metal ion binding  
    enables protein binding PubMed 
    enables protein serine kinase activity  
    enables protein serine/threonine kinase activity  
    enables ribosomal protein S6 kinase activity  
    Items 1 - 25 of 30
    Items 1 - 25 of 32
    Process Evidence Code Pubs
    involved_in adult locomotory behavior  
    acts_upstream_of_or_within adult locomotory behavior  
    involved_in axon guidance  
    involved_in axonogenesis PubMed 
    involved_in chromatin remodeling  
    involved_in habituation  
    acts_upstream_of_or_within habituation  
    involved_in intracellular signal transduction  
    involved_in intracellular signal transduction PubMed 
    involved_in lactation  
    acts_upstream_of_or_within lactation  
    involved_in maternal behavior  
    acts_upstream_of_or_within maternal behavior  
    involved_in maternal process involved in parturition  
    acts_upstream_of_or_within maternal process involved in parturition  
    involved_in memory  
    acts_upstream_of_or_within memory  
    involved_in negative regulation of growth hormone secretion  
    acts_upstream_of_or_within negative regulation of growth hormone secretion  
    involved_in nervous system development PubMed 
    involved_in neuromuscular junction development  
    acts_upstream_of_or_within neuromuscular junction development  
    acts_upstream_of_or_within positive regulation of GTPase activity  
    involved_in positive regulation of dendritic spine morphogenesis  
    acts_upstream_of_or_within positive regulation of dendritic spine morphogenesis  
    involved_in regulation of dendrite development PubMed 
    involved_in regulation of modification of postsynaptic actin cytoskeleton PubMed 
    involved_in regulation of modification of postsynaptic actin cytoskeleton PubMed 
    involved_in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane PubMed 
    involved_in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane PubMed 
    involved_in social behavior  
    acts_upstream_of_or_within social behavior  
    Items 1 - 25 of 32
    Component Evidence Code Pubs
    is_active_in cytoplasm  
    located_in cytoplasm  
    located_in cytoskeleton  
    located_in cytosol  
    located_in cytosol  
    is_active_in extrinsic component of membrane  
    is_active_in glutamatergic synapse PubMed 
    is_active_in glutamatergic synapse PubMed 
    located_in neuronal cell body PubMed 
    located_in nucleoplasm  
    located_in nucleoplasm  
    located_in perinuclear region of cytoplasm PubMed 
    is_active_in postsynaptic density  
    is_active_in postsynaptic density PubMed 
    is_active_in postsynaptic density PubMed 
    is_active_in presynapse PubMed 
    is_active_in presynapse PubMed 

    General protein information

    Preferred Names
    kalirin
    Names
    P-CIP10
    PAM COOH-terminal interactor protein 10
    cyclin B1
    huntingtin-associated protein interacting protein (duo)
    huntingtin-associated protein-interacting protein
    protein Duo
    serine/threonine kinase with Dbl- and pleckstrin homology domain
    serine/threonine-protein kinase with Dbl- and pleckstrin homology domain
    NP_114451.2
    XP_038944566.1
    XP_038944567.1
    XP_038944568.1
    XP_038944569.1
    XP_038944570.1
    XP_038944571.1
    XP_038944572.1
    XP_038944573.1
    XP_038944574.1
    XP_038944575.1
    XP_038944576.1
    XP_038944577.1
    XP_038944578.1
    XP_038944579.1
    XP_038944580.1
    XP_038944581.1
    XP_038944582.1
    XP_038944583.1
    XP_038944584.1
    XP_038944585.1
    XP_038944586.1
    XP_038944588.1
    XP_038944589.1
    XP_038944590.1
    XP_038944591.1
    XP_038944592.1
    XP_038944593.1
    XP_038944594.1
    XP_038944595.1
    XP_063126848.1
    XP_063126849.1
    XP_063126850.1
    XP_063126851.1
    XP_063126852.1
    XP_063126853.1
    XP_063126854.1
    XP_063126855.1
    XP_063126856.1
    XP_063126857.1
    XP_063126858.1
    XP_063126859.1
    XP_063126860.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_032062.2NP_114451.2  kalirin

      Status: VALIDATED

      Source sequence(s)
      AF230644, AF232669
      UniProtKB/TrEMBL
      A0A8I6GKY9
      Conserved Domains (16) summary
      cd00096
      Location:24792553
      Ig; Immunoglobulin domain
      smart00150
      Location:11261226
      SPEC; Spectrin repeats
      cd11852
      Location:16401699
      SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
      cd11853
      Location:23152373
      SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
      smart00220
      Location:26752929
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      smart00516
      Location:39177
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00063
      Location:25602651
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00160
      Location:12751445
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:8911120
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam07679
      Location:24622556
      I-set; Immunoglobulin I-set domain
      cd13240
      Location:14521574
      PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
      cd13241
      Location:20972231
      PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
      cd14115
      Location:26812928
      STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
      pfam00169
      Location:14851570
      PH; PH domain
      pfam00621
      Location:19232093
      RhoGEF; RhoGEF domain
      pfam16609
      Location:16961880
      SH3-RhoG_link; SH3-RhoGEF linking unstructured region

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086029.1 Reference GRCr8

      Range
      79703345..80309210
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039088642.2XP_038944570.1  kalirin isoform X5

      UniProtKB/TrEMBL
      A0A8I6ACF7
      Conserved Domains (14) summary
      smart00150
      Location:11371237
      SPEC; Spectrin repeats
      cd11852
      Location:16511710
      SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
      cd11853
      Location:23242382
      SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
      smart00516
      Location:41179
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00063
      Location:25692660
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00160
      Location:12861456
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:8931131
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cd13240
      Location:14631585
      PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
      cd13241
      Location:21072241
      PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
      cd14115
      Location:26902937
      STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
      pfam00621
      Location:19332102
      RhoGEF; RhoGEF domain
      pfam07679
      Location:24712565
      I-set; Immunoglobulin I-set domain
      pfam16609
      Location:17071890
      SH3-RhoG_link; SH3-RhoGEF linking unstructured region
      cd00096
      Location:24632466
      Ig; Ig strand A [structural motif]
    2. XM_039088658.2XP_038944586.1  kalirin isoform X27

      UniProtKB/TrEMBL
      A6IRJ3
      Conserved Domains (7) summary
      smart00150
      Location:11281228
      SPEC; Spectrin repeats
      cd11852
      Location:16421701
      SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
      smart00516
      Location:41179
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00160
      Location:12771447
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:8931122
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cd13240
      Location:14541576
      PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
      pfam16609
      Location:16981879
      SH3-RhoG_link; SH3-RhoGEF linking unstructured region
    3. XM_039088661.2XP_038944589.1  kalirin isoform X29

      UniProtKB/TrEMBL
      A0A8L2Q7U3, A6IRJ4
      Related
      ENSRNOP00000016340.8, ENSRNOT00000016340.9
      Conserved Domains (6) summary
      smart00150
      Location:11371237
      SPEC; Spectrin repeats
      smart00516
      Location:41179
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00160
      Location:12861456
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:8931131
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cd13240
      Location:14631585
      PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
      TIGR02168
      Location:747993
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    4. XM_039088664.2XP_038944592.1  kalirin isoform X32

      UniProtKB/TrEMBL
      A6IRJ4
      Conserved Domains (5) summary
      smart00150
      Location:11281228
      SPEC; Spectrin repeats
      smart00516
      Location:41179
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00160
      Location:12771447
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:8931122
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cd13240
      Location:14541576
      PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
    5. XM_039088640.2XP_038944568.1  kalirin isoform X3

      UniProtKB/TrEMBL
      A0A8I6GKY9
      Conserved Domains (14) summary
      smart00150
      Location:11381238
      SPEC; Spectrin repeats
      cd11852
      Location:16521711
      SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
      cd11853
      Location:23262384
      SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
      smart00516
      Location:42180
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00063
      Location:25712662
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00160
      Location:12871457
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:8941132
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cd13240
      Location:14641586
      PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
      cd13241
      Location:21082242
      PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
      cd14115
      Location:26922939
      STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
      pfam00621
      Location:19342103
      RhoGEF; RhoGEF domain
      pfam07679
      Location:24732567
      I-set; Immunoglobulin I-set domain
      pfam16609
      Location:17081891
      SH3-RhoG_link; SH3-RhoGEF linking unstructured region
      cd00096
      Location:24652468
      Ig; Ig strand A [structural motif]
    6. XM_039088645.2XP_038944573.1  kalirin isoform X8

      UniProtKB/TrEMBL
      A0A8I6GKY9
      Conserved Domains (14) summary
      smart00150
      Location:11251225
      SPEC; Spectrin repeats
      cd11852
      Location:16391698
      SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
      cd11853
      Location:23142372
      SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
      smart00516
      Location:42180
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00063
      Location:25592650
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00160
      Location:12741444
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:540756
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cd13240
      Location:14511573
      PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
      cd13241
      Location:20962230
      PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
      cd14115
      Location:26802927
      STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
      pfam00621
      Location:19222091
      RhoGEF; RhoGEF domain
      pfam07679
      Location:24612555
      I-set; Immunoglobulin I-set domain
      pfam16609
      Location:16951879
      SH3-RhoG_link; SH3-RhoGEF linking unstructured region
      cd00096
      Location:24532456
      Ig; Ig strand A [structural motif]
    7. XM_039088647.2XP_038944575.1  kalirin isoform X10

      UniProtKB/TrEMBL
      A0A8I6GKY9
      Conserved Domains (14) summary
      smart00150
      Location:11161216
      SPEC; Spectrin repeats
      cd11852
      Location:16301689
      SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
      cd11853
      Location:23052363
      SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
      smart00516
      Location:42180
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00063
      Location:25502641
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00160
      Location:12651435
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:8811110
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cd13240
      Location:14421564
      PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
      cd13241
      Location:20872221
      PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
      cd14115
      Location:26712918
      STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
      pfam00621
      Location:19132082
      RhoGEF; RhoGEF domain
      pfam07679
      Location:24522546
      I-set; Immunoglobulin I-set domain
      pfam16609
      Location:16861870
      SH3-RhoG_link; SH3-RhoGEF linking unstructured region
      cd00096
      Location:24442447
      Ig; Ig strand A [structural motif]
    8. XM_039088638.2XP_038944566.1  kalirin isoform X1

      UniProtKB/TrEMBL
      A0A8I6GKY9
      Conserved Domains (14) summary
      smart00150
      Location:11381238
      SPEC; Spectrin repeats
      cd11852
      Location:16521711
      SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
      cd11853
      Location:23272385
      SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
      smart00516
      Location:42180
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00063
      Location:25722663
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00160
      Location:12871457
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:8941132
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cd13240
      Location:14641586
      PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
      cd13241
      Location:21092243
      PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
      cd14115
      Location:26932940
      STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
      pfam00621
      Location:19352104
      RhoGEF; RhoGEF domain
      pfam07679
      Location:24742568
      I-set; Immunoglobulin I-set domain
      pfam16609
      Location:17081892
      SH3-RhoG_link; SH3-RhoGEF linking unstructured region
      cd00096
      Location:24662469
      Ig; Ig strand A [structural motif]
    9. XM_039088646.2XP_038944574.1  kalirin isoform X9

      UniProtKB/TrEMBL
      A0A8I6GKY9
      Conserved Domains (14) summary
      smart00150
      Location:11381238
      SPEC; Spectrin repeats
      cd11852
      Location:16521711
      SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
      cd11853
      Location:23272385
      SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
      smart00516
      Location:42180
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00063
      Location:25522643
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00160
      Location:12871457
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:8941132
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cd13240
      Location:14641586
      PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
      cd13241
      Location:21092243
      PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
      cd14115
      Location:26732920
      STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
      pfam00621
      Location:19352104
      RhoGEF; RhoGEF domain
      pfam07679
      Location:24542548
      I-set; Immunoglobulin I-set domain
      pfam16609
      Location:17081892
      SH3-RhoG_link; SH3-RhoGEF linking unstructured region
      cd00096
      Location:24462449
      Ig; Ig strand A [structural motif]
    10. XM_039088639.2XP_038944567.1  kalirin isoform X2

      UniProtKB/TrEMBL
      A0A8I6GKY9
      Conserved Domains (14) summary
      smart00150
      Location:11381238
      SPEC; Spectrin repeats
      cd11852
      Location:16521711
      SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
      cd11853
      Location:23262384
      SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
      smart00516
      Location:42180
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00063
      Location:25712662
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00160
      Location:12871457
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:8941132
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cd13240
      Location:14641586
      PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
      cd13241
      Location:21092243
      PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
      cd14115
      Location:26922939
      STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
      pfam00621
      Location:19352104
      RhoGEF; RhoGEF domain
      pfam07679
      Location:24732567
      I-set; Immunoglobulin I-set domain
      pfam16609
      Location:17081892
      SH3-RhoG_link; SH3-RhoGEF linking unstructured region
      cd00096
      Location:24652468
      Ig; Ig strand A [structural motif]
    11. XM_039088650.2XP_038944578.1  kalirin isoform X14

      UniProtKB/TrEMBL
      A0A8I6GKY9
      Conserved Domains (14) summary
      smart00150
      Location:11381238
      SPEC; Spectrin repeats
      cd11852
      Location:16521711
      SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
      cd11853
      Location:22952353
      SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
      smart00516
      Location:42180
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00063
      Location:25402631
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00160
      Location:12871457
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:8941132
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cd13240
      Location:14641586
      PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
      cd13241
      Location:20772211
      PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
      cd14115
      Location:26612908
      STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
      pfam00621
      Location:19032072
      RhoGEF; RhoGEF domain
      pfam07679
      Location:24422536
      I-set; Immunoglobulin I-set domain
      pfam16609
      Location:17081847
      SH3-RhoG_link; SH3-RhoGEF linking unstructured region
      cd00096
      Location:24342437
      Ig; Ig strand A [structural motif]
    12. XM_039088644.2XP_038944572.1  kalirin isoform X7

      UniProtKB/TrEMBL
      A0A8I6GKY9
      Conserved Domains (14) summary
      smart00150
      Location:11291229
      SPEC; Spectrin repeats
      cd11852
      Location:16431702
      SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
      cd11853
      Location:23182376
      SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
      smart00516
      Location:42180
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00063
      Location:25632654
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00160
      Location:12781448
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:8941123
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cd13240
      Location:14551577
      PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
      cd13241
      Location:21002234
      PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
      cd14115
      Location:26842931
      STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
      pfam00621
      Location:19262095
      RhoGEF; RhoGEF domain
      pfam07679
      Location:24652559
      I-set; Immunoglobulin I-set domain
      pfam16609
      Location:16991883
      SH3-RhoG_link; SH3-RhoGEF linking unstructured region
      cd00096
      Location:24572460
      Ig; Ig strand A [structural motif]
    13. XM_039088641.2XP_038944569.1  kalirin isoform X4

      UniProtKB/TrEMBL
      A0A8I6GKY9
      Conserved Domains (14) summary
      smart00150
      Location:11351235
      SPEC; Spectrin repeats
      cd11852
      Location:16491708
      SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
      cd11853
      Location:23242382
      SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
      smart00516
      Location:39177
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00063
      Location:25692660
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00160
      Location:12841454
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:8911129
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cd13240
      Location:14611583
      PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
      cd13241
      Location:21062240
      PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
      cd14115
      Location:26902937
      STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
      pfam00621
      Location:19322101
      RhoGEF; RhoGEF domain
      pfam07679
      Location:24712565
      I-set; Immunoglobulin I-set domain
      pfam16609
      Location:17051889
      SH3-RhoG_link; SH3-RhoGEF linking unstructured region
      cd00096
      Location:24632466
      Ig; Ig strand A [structural motif]
    14. XM_039088643.2XP_038944571.1  kalirin isoform X6

      UniProtKB/TrEMBL
      A0A8I6GKY9
      Conserved Domains (14) summary
      smart00150
      Location:11351235
      SPEC; Spectrin repeats
      cd11852
      Location:16491708
      SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
      cd11853
      Location:23232381
      SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
      smart00516
      Location:39177
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00063
      Location:25682659
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00160
      Location:12841454
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:8911129
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cd13240
      Location:14611583
      PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
      cd13241
      Location:21062240
      PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
      cd14115
      Location:26892936
      STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
      pfam00621
      Location:19322101
      RhoGEF; RhoGEF domain
      pfam07679
      Location:24702564
      I-set; Immunoglobulin I-set domain
      pfam16609
      Location:17051889
      SH3-RhoG_link; SH3-RhoGEF linking unstructured region
      cd00096
      Location:24622465
      Ig; Ig strand A [structural motif]
    15. XM_039088649.2XP_038944577.1  kalirin isoform X12

      UniProtKB/TrEMBL
      A0A8I6GKY9
      Conserved Domains (14) summary
      smart00150
      Location:11381238
      SPEC; Spectrin repeats
      cd11852
      Location:16521711
      SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
      cd11853
      Location:22962354
      SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
      smart00516
      Location:42180
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00063
      Location:25412632
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00160
      Location:12871457
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:8941132
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cd13240
      Location:14641586
      PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
      cd13241
      Location:20782212
      PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
      cd14115
      Location:26622909
      STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
      pfam00621
      Location:19042073
      RhoGEF; RhoGEF domain
      pfam07679
      Location:24432537
      I-set; Immunoglobulin I-set domain
      pfam16609
      Location:17081848
      SH3-RhoG_link; SH3-RhoGEF linking unstructured region
      cd00096
      Location:24352438
      Ig; Ig strand A [structural motif]
    16. XM_063270778.1XP_063126848.1  kalirin isoform X13

      UniProtKB/TrEMBL
      A0A8I6A0Z4, A0A8I6GKY9
    17. XM_039088666.2XP_038944594.1  kalirin isoform X34

      UniProtKB/TrEMBL
      A6IRJ4
      Conserved Domains (6) summary
      smart00150
      Location:11251225
      SPEC; Spectrin repeats
      smart00516
      Location:42180
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00160
      Location:12741444
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:540756
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cd13240
      Location:14511573
      PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
      TIGR02168
      Location:735981
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    18. XM_039088667.2XP_038944595.1  kalirin isoform X35

      UniProtKB/TrEMBL
      A6IRJ4
      Conserved Domains (5) summary
      smart00150
      Location:11161216
      SPEC; Spectrin repeats
      smart00516
      Location:42180
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00160
      Location:12651435
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:8811110
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cd13240
      Location:14421564
      PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
    19. XM_039088660.2XP_038944588.1  kalirin isoform X28

      UniProtKB/TrEMBL
      A6IRJ4
      Conserved Domains (6) summary
      smart00150
      Location:11381238
      SPEC; Spectrin repeats
      smart00516
      Location:42180
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00160
      Location:12871457
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:8941132
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cd13240
      Location:14641586
      PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
      TIGR02168
      Location:748994
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    20. XM_039088663.2XP_038944591.1  kalirin isoform X31

      UniProtKB/TrEMBL
      A6IRJ4
      Conserved Domains (5) summary
      smart00150
      Location:11291229
      SPEC; Spectrin repeats
      smart00516
      Location:42180
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00160
      Location:12781448
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:8941123
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cd13240
      Location:14551577
      PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
    21. XM_039088662.2XP_038944590.1  kalirin isoform X30

      UniProtKB/TrEMBL
      A6IRJ4
      Conserved Domains (6) summary
      smart00150
      Location:11351235
      SPEC; Spectrin repeats
      smart00516
      Location:39177
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00160
      Location:12841454
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:8911129
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cd13240
      Location:14611583
      PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
      TIGR02168
      Location:745991
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    22. XM_039088665.2XP_038944593.1  kalirin isoform X33

      UniProtKB/TrEMBL
      A6IRJ4
      Conserved Domains (5) summary
      smart00150
      Location:11261226
      SPEC; Spectrin repeats
      smart00516
      Location:39177
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00160
      Location:12751445
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:8911120
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cd13240
      Location:14521574
      PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
    23. XM_039088651.2XP_038944579.1  kalirin isoform X15

      UniProtKB/TrEMBL
      A6IRJ0
      Conserved Domains (11) summary
      smart00150
      Location:11381238
      SPEC; Spectrin repeats
      cd11852
      Location:16521711
      SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
      cd11853
      Location:23272385
      SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
      smart00516
      Location:42180
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00160
      Location:12871457
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:8941132
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cd13240
      Location:14641586
      PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
      cd13241
      Location:21092243
      PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
      TIGR02168
      Location:748994
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam00621
      Location:19352104
      RhoGEF; RhoGEF domain
      pfam16609
      Location:17081892
      SH3-RhoG_link; SH3-RhoGEF linking unstructured region
    24. XM_039088654.2XP_038944582.1  kalirin isoform X21

      UniProtKB/TrEMBL
      A6IRJ0
      Conserved Domains (11) summary
      smart00150
      Location:11381238
      SPEC; Spectrin repeats
      cd11852
      Location:16521711
      SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
      cd11853
      Location:23252383
      SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
      smart00516
      Location:42180
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00160
      Location:12871457
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:8941132
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cd13240
      Location:14641586
      PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
      cd13241
      Location:21082242
      PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
      TIGR02168
      Location:748994
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam00621
      Location:19342103
      RhoGEF; RhoGEF domain
      pfam16609
      Location:17081891
      SH3-RhoG_link; SH3-RhoGEF linking unstructured region
    25. XM_039088653.2XP_038944581.1  kalirin isoform X17

      UniProtKB/TrEMBL
      A6IRJ0
      Conserved Domains (11) summary
      smart00150
      Location:11381238
      SPEC; Spectrin repeats
      cd11852
      Location:16521711
      SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
      cd11853
      Location:23272385
      SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
      smart00516
      Location:42180
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00160
      Location:12871457
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:8941132
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cd13240
      Location:14641586
      PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
      cd13241
      Location:21092243
      PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
      TIGR02168
      Location:748994
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam00621
      Location:19352104
      RhoGEF; RhoGEF domain
      pfam16609
      Location:17081892
      SH3-RhoG_link; SH3-RhoGEF linking unstructured region
    26. XM_039088652.2XP_038944580.1  kalirin isoform X16

      UniProtKB/TrEMBL
      A6IRJ0
      Conserved Domains (11) summary
      smart00150
      Location:11381238
      SPEC; Spectrin repeats
      cd11852
      Location:16521711
      SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
      cd11853
      Location:23272385
      SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
      smart00516
      Location:42180
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00160
      Location:12871457
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:8941132
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cd13240
      Location:14641586
      PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
      cd13241
      Location:21092243
      PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
      TIGR02168
      Location:748994
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam00621
      Location:19352104
      RhoGEF; RhoGEF domain
      pfam16609
      Location:17081892
      SH3-RhoG_link; SH3-RhoGEF linking unstructured region
    27. XM_063270779.1XP_063126849.1  kalirin isoform X18

      UniProtKB/TrEMBL
      A6IRJ0
    28. XM_039088655.2XP_038944583.1  kalirin isoform X22

      UniProtKB/TrEMBL
      A6IRJ0
      Conserved Domains (10) summary
      smart00150
      Location:11291229
      SPEC; Spectrin repeats
      cd11852
      Location:16431702
      SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
      cd11853
      Location:23182376
      SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
      smart00516
      Location:42180
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00160
      Location:12781448
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:8941123
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cd13240
      Location:14551577
      PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
      cd13241
      Location:21002234
      PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
      pfam00621
      Location:19262095
      RhoGEF; RhoGEF domain
      pfam16609
      Location:16991883
      SH3-RhoG_link; SH3-RhoGEF linking unstructured region
    29. XM_063270781.1XP_063126851.1  kalirin isoform X20

      UniProtKB/TrEMBL
      A6IRJ0
    30. XM_063270780.1XP_063126850.1  kalirin isoform X19

      UniProtKB/TrEMBL
      A6IRJ0
    31. XM_063270782.1XP_063126852.1  kalirin isoform X24

      UniProtKB/TrEMBL
      A6IRJ0
    32. XM_063270783.1XP_063126853.1  kalirin isoform X25

      UniProtKB/TrEMBL
      A6IRJ0
    33. XM_039088648.2XP_038944576.1  kalirin isoform X11

      UniProtKB/Swiss-Prot
      O70135, P97924, Q6IV51, Q9JIF1, Q9JIF2, Q9JIG0, Q9JIH3
      UniProtKB/TrEMBL
      A0A2X0SFF1
      Conserved Domains (14) summary
      smart00150
      Location:11081208
      SPEC; Spectrin repeats
      cd11852
      Location:16221681
      SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
      cd11853
      Location:22972355
      SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
      smart00516
      Location:21159
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00063
      Location:25422633
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00160
      Location:12571427
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:8731102
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cd13240
      Location:14341556
      PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
      cd13241
      Location:20792213
      PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
      cd14115
      Location:26632910
      STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
      pfam00621
      Location:19052074
      RhoGEF; RhoGEF domain
      pfam07679
      Location:24442538
      I-set; Immunoglobulin I-set domain
      pfam16609
      Location:16781862
      SH3-RhoG_link; SH3-RhoGEF linking unstructured region
      cd00096
      Location:24362439
      Ig; Ig strand A [structural motif]
    34. XM_039088656.2XP_038944584.1  kalirin isoform X23

      UniProtKB/TrEMBL
      A6IRJ0
      Conserved Domains (10) summary
      smart00150
      Location:11081208
      SPEC; Spectrin repeats
      cd11852
      Location:16221681
      SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
      cd11853
      Location:22972355
      SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
      smart00516
      Location:21159
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00160
      Location:12571427
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:8731102
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cd13240
      Location:14341556
      PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
      cd13241
      Location:20792213
      PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
      pfam00621
      Location:19052074
      RhoGEF; RhoGEF domain
      pfam16609
      Location:16781862
      SH3-RhoG_link; SH3-RhoGEF linking unstructured region
    35. XM_039088657.2XP_038944585.1  kalirin isoform X26

      UniProtKB/TrEMBL
      A6IRI9
      Conserved Domains (14) summary
      smart00150
      Location:494594
      SPEC; Spectrin repeats
      cd11852
      Location:10081067
      SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
      cd11853
      Location:16831741
      SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
      cd00063
      Location:19282019
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00160
      Location:643813
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:250488
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cd13240
      Location:820942
      PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
      cd13241
      Location:14651599
      PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
      cd14115
      Location:20492296
      STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
      pfam00621
      Location:12911460
      RhoGEF; RhoGEF domain
      pfam07679
      Location:18301924
      I-set; Immunoglobulin I-set domain
      pfam16609
      Location:10641248
      SH3-RhoG_link; SH3-RhoGEF linking unstructured region
      cd00096
      Location:18221825
      Ig; Ig strand A [structural motif]
      cl02488
      Location:5249
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    36. XM_063270784.1XP_063126854.1  kalirin isoform X36

      UniProtKB/TrEMBL
      A0A8I6AUW1
      Related
      ENSRNOP00000097769.1, ENSRNOT00000101686.2
    37. XM_063270785.1XP_063126855.1  kalirin isoform X37

      UniProtKB/TrEMBL
      A0A8I6AUW1
    38. XM_063270786.1XP_063126856.1  kalirin isoform X38

      UniProtKB/TrEMBL
      A0A8I5ZVT3
    39. XM_063270789.1XP_063126859.1  kalirin isoform X41

      UniProtKB/TrEMBL
      A0A8I5ZVT3
    40. XM_063270790.1XP_063126860.1  kalirin isoform X42

      UniProtKB/TrEMBL
      A0A8I5ZVT3
    41. XM_063270787.1XP_063126857.1  kalirin isoform X39

      UniProtKB/TrEMBL
      A0A8I5ZVT3
    42. XM_063270788.1XP_063126858.1  kalirin isoform X40

      UniProtKB/TrEMBL
      A0A8I5ZVT3
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