Insyn1 inhibitory synaptic factor 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Insyn1provided by RGD
Official Full Name: inhibitory synaptic factor 1provided by RGD
Primary source: RGD:1562618
See related: AllianceGenome:RGD:1562618
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1562618
Summary: Predicted to be involved in inhibitory postsynaptic potential and postsynaptic specialization organization. Predicted to be active in GABA-ergic synapse and postsynaptic density. Orthologous to human INSYN1 (inhibitory synaptic factor 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 140.8), Kidney (RPKM 76.5) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 8q24

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (67799989..67810685)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (58904153..58914850)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (63286841..63297080)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

NoName (e-PCR)
- UniSTS:493188

RH133239 (e-PCR)
- UniSTS:216522

Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
involved_in chemical synaptic transmission, postsynaptic	ISO Inferred from Sequence Orthology more info
involved_in inhibitory postsynaptic potential	IBA Inferred from Biological aspect of Ancestor more info
involved_in inhibitory postsynaptic potential	ISO Inferred from Sequence Orthology more info
involved_in inhibitory postsynaptic potential	ISS Inferred from Sequence or Structural Similarity more info
involved_in postsynaptic specialization organization	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in GABA-ergic synapse	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic density	IBA Inferred from Biological aspect of Ancestor more info
located_in postsynaptic density	ISO Inferred from Sequence Orthology more info
located_in postsynaptic density	ISS Inferred from Sequence or Structural Similarity more info
is_active_in postsynaptic specialization	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: inhibitory synaptic factor 1

Names: UPF0583 protein C15orf59 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001113791.1 → NP_001107263.1 inhibitory synaptic factor 1

See identical proteins and their annotated locations for NP_001107263.1

Status: PROVISIONAL

Source sequence(s)

BC158644

UniProtKB/Swiss-Prot

B0BN13

UniProtKB/TrEMBL

A6J508

Conserved Domains (1) summary

pfam15252
Location:52 → 278

DUF4589; Domain of unknown function (DUF4589)