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    Sugt1 SGT1 homolog, MIS12 kinetochore complex assembly cochaperone [ Rattus norvegicus (Norway rat) ]

    Gene ID: 290408, updated on 9-Dec-2024

    Summary

    Official Symbol
    Sugt1provided by RGD
    Official Full Name
    SGT1 homolog, MIS12 kinetochore complex assembly cochaperoneprovided by RGD
    Primary source
    RGD:1307550
    See related
    EnsemblRapid:ENSRNOG00000012594 AllianceGenome:RGD:1307550
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Aa1114
    Summary
    Predicted to enable lncRNA binding activity. Predicted to be involved in kinetochore assembly and regulation of protein stability. Predicted to act upstream of or within skeletal muscle satellite cell proliferation and spindle organization. Predicted to be located in cytoplasm and kinetochore. Predicted to be part of protein-containing complex. Orthologous to human SUGT1 (SGT1 homolog, MIS12 kinetochore complex assembly cochaperone). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Muscle (RPKM 252.8), Heart (RPKM 217.4) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Sugt1 in Genome Data Viewer
    Location:
    15q12
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (61400478..61441303)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (54991419..55032244)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (61873158..61913983)

    Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene transfer RNA glutamic acid (anticodon UUC) 8 Neighboring gene microfibrillar-associated protein 1-like Neighboring gene E74 like ETS transcription factor 1 Neighboring gene uncharacterized LOC134481994 Neighboring gene chondromodulin Neighboring gene microRNA 759

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables lncRNA binding  
    enables lncRNA binding  
    enables protein-folding chaperone binding  
    Process Evidence Code Pubs
    involved_in kinetochore assembly  
    acts_upstream_of_or_within kinetochore assembly  
    involved_in kinetochore assembly  
    involved_in kinetochore assembly  
    involved_in regulation of protein stability  
    involved_in skeletal muscle satellite cell proliferation  
    acts_upstream_of_or_within skeletal muscle satellite cell proliferation  
    involved_in spindle organization  
    acts_upstream_of_or_within spindle organization  
    Component Evidence Code Pubs
    located_in cytoplasm  
    located_in cytoplasm  
    located_in kinetochore  
    located_in kinetochore  
    located_in nucleus  
    part_of protein-containing complex  

    General protein information

    Preferred Names
    protein SGT1 homolog
    Names
    Suppressor of G2 allele of SKP1 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013051.1NP_001013069.1  protein SGT1 homolog

      See identical proteins and their annotated locations for NP_001013069.1

      Status: PROVISIONAL

      Source sequence(s)
      BC158724
      UniProtKB/Swiss-Prot
      B0BN85
      UniProtKB/TrEMBL
      A0A8I6A2D1, A6HU03
      Related
      ENSRNOP00000085823.2, ENSRNOT00000110035.2
      Conserved Domains (5) summary
      cd06489
      Location:146229
      p23_CS_hSgt1_like; p23_like domain similar to the C-terminal CS (CHORD-SGT1) domain of human (h) Sgt1 and related proteins. hSgt1 is a co-chaperone which has been shown to be elevated in HEp-2 cells as a result of stress conditions such as heat shock. It interacts with the ...
      smart00028
      Location:4578
      TPR; Tetratricopeptide repeats
      PLN03088
      Location:21336
      PLN03088; SGT1, suppressor of G2 allele of SKP1; Provisional
      sd00006
      Location:4474
      TPR; TPR repeat [structural motif]
      pfam05002
      Location:256336
      SGS; SGS domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086033.1 Reference GRCr8

      Range
      61400478..61441303
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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