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    Wdfy2 WD repeat and FYVE domain containing 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 305956, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Wdfy2provided by RGD
    Official Full Name
    WD repeat and FYVE domain containing 2provided by RGD
    Primary source
    RGD:1307337
    See related
    EnsemblRapid:ENSRNOG00000010042 AllianceGenome:RGD:1307337
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable metal ion binding activity. Predicted to be involved in positive regulation of fat cell differentiation and positive regulation of protein phosphorylation. Predicted to be located in cytoplasm; intracellular membrane-bounded organelle; and vesicle. Predicted to be active in early endosome. Orthologous to human WDFY2 (WD repeat and FYVE domain containing 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 250.6), Spleen (RPKM 112.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Wdfy2 in Genome Data Viewer
    Location:
    15p12
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (41259840..41385549)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (37083842..37209559)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (46008613..46134319)

    Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene integrator complex subunit 6 Neighboring gene Sec61 translocon subunit gamma, pseudogene 5 Neighboring gene zinc finger CCCH domain-containing protein 13-like Neighboring gene large ribosomal subunit protein eL27-like Neighboring gene uncharacterized LOC120097010 Neighboring gene ribosomal protein L23a, pseudogene 2 Neighboring gene defensin beta 42 Neighboring gene defensin beta 41

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Akt- and Foxo1-interacting WD-repeat-FYVE protein promotes adipogenesis. Fritzius T, et al. EMBO J, 2008 May 7. PMID 18388859, Free PMC Article
    2. WD-repeat-propeller-FYVE protein, ProF, binds VAMP2 and protein kinase Czeta. Fritzius T, et al. FEBS J, 2007 Mar. PMID 17313651
    3. A WD-FYVE protein binds to the kinases Akt and PKCzeta/lambda. Fritzius T, et al. Biochem J, 2006 Oct 1. PMID 16792529, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of fat cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of fat cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in early endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in early endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    WD repeat and FYVE domain-containing protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107269.1 → NP_001100739.1  WD repeat and FYVE domain-containing protein 2 isoform 1

      See identical proteins and their annotated locations for NP_001100739.1

      Status: PROVISIONAL

      Source sequence(s)
      CH474023
      UniProtKB/TrEMBL
      A6K6E4, A6K6E5, D4A0J0
      Conserved Domains (5) summary
      smart00320
      Location:285 → 321
      WD40; WD40 repeats
      COG2319
      Location:2 → 321
      WD40; WD40 repeat [General function prediction only]
      cd15718
      Location:206 → 275
      FYVE_WDFY1_like; FYVE domain found in WD40 repeat and FYVE domain-containing protein WDFY1 and WDFY2, and similar proteins
      sd00039
      Location:86 → 124
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:27 → 199
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    2. NM_001415102.1 → NP_001402031.1  WD repeat and FYVE domain-containing protein 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000015
      UniProtKB/TrEMBL
      A0A0G2K8S4
      Related
      ENSRNOP00000061576.2, ENSRNOT00000066864.4

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086033.1 Reference GRCr8

      Range
      41259840..41385549
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063274283.1 → XP_063130353.1  WD repeat and FYVE domain-containing protein 2 isoform X2

      UniProtKB/TrEMBL
      A6K6E5

    2. XM_039093327.2 → XP_038949255.1  WD repeat and FYVE domain-containing protein 2 isoform X3

      UniProtKB/TrEMBL
      A6K6E6
      Conserved Domains (3) summary
      cd15718
      Location:190 → 259
      FYVE_WDFY1_like; FYVE domain found in WD40 repeat and FYVE domain-containing protein WDFY1 and WDFY2, and similar proteins
      sd00039
      Location:70 → 108
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:11 → 183
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    3. XM_039093325.2 → XP_038949253.1  WD repeat and FYVE domain-containing protein 2 isoform X1

      UniProtKB/TrEMBL
      A6K6E5
      Related
      ENSRNOP00000074718.2, ENSRNOT00000080537.3
      Conserved Domains (3) summary
      cd15718
      Location:241 → 310
      FYVE_WDFY1_like; FYVE domain found in WD40 repeat and FYVE domain-containing protein WDFY1 and WDFY2, and similar proteins
      sd00039
      Location:121 → 159
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:30 → 238
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    4. XM_039093328.1 → XP_038949256.1  WD repeat and FYVE domain-containing protein 2 isoform X4

      Conserved Domains (3) summary
      cd15718
      Location:161 → 230
      FYVE_WDFY1_like; FYVE domain found in WD40 repeat and FYVE domain-containing protein WDFY1 and WDFY2, and similar proteins
      sd00039
      Location:41 → 79
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:9 → 154
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    Nucleotide Protein Strain
    Heading Accession and Version

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