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    Wwc1 WW and C2 domain containing 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 303039, updated on 9-Dec-2024

    Summary

    Official Symbol
    Wwc1provided by RGD
    Official Full Name
    WW and C2 domain containing 1provided by RGD
    Primary source
    RGD:1308329
    See related
    EnsemblRapid:ENSRNOG00000008065 AllianceGenome:RGD:1308329
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1308329
    Summary
    Enables protein-macromolecule adaptor activity. Involved in cell migration. Part of protein-containing complex. Is active in postsynaptic density, intracellular component. Orthologous to human WWC1 (WW and C2 domain containing 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 234.0), Lung (RPKM 95.9) and 3 other tissues See more
    Orthologs
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    Genomic context

    See Wwc1 in Genome Data Viewer
    Location:
    10q12
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (20804173..20958437, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (20300735..20454393, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (20662996..20818500, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene fibrillarin-like 1 Neighboring gene uncharacterized LOC134480662 Neighboring gene arginyl-tRNA synthetase 1 Neighboring gene teneurin transmembrane protein 2 Neighboring gene uncharacterized LOC108352202 Neighboring gene uncharacterized LOC120095252

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables kinase binding  
    enables kinase binding  
    enables molecular adaptor activity  
    enables molecular adaptor activity  
    enables protein-macromolecule adaptor activity PubMed 
    enables signaling adaptor activity  
    enables transcription coactivator activity  
    Process Evidence Code Pubs
    involved_in cell migration  
    involved_in cell migration PubMed 
    involved_in cell migration  
    involved_in hippo signaling  
    involved_in negative regulation of cell population proliferation  
    involved_in negative regulation of hippo signaling  
    involved_in negative regulation of organ growth  
    involved_in negative regulation of organ growth  
    involved_in negative regulation of transcription by RNA polymerase II  
    involved_in positive regulation of DNA-templated transcription  
    involved_in positive regulation of MAPK cascade  
    involved_in regulation of DNA-templated transcription  
    involved_in regulation of hippo signaling  
    involved_in regulation of hippo signaling  
    Component Evidence Code Pubs
    is_active_in cytoplasm  
    is_active_in cytoplasm  
    located_in cytoplasm  
    located_in cytosol  
    located_in nucleus  
    located_in perinuclear region of cytoplasm  
    is_active_in postsynaptic density, intracellular component PubMed 
    part_of protein-containing complex PubMed 
    located_in ruffle membrane  

    General protein information

    Preferred Names
    protein KIBRA
    Names
    WW, C2 and coiled-coil domain containing 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001427362.1NP_001414291.1  protein KIBRA

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      A6HDJ2, F1M6U0
      Related
      ENSRNOP00000101995.1, ENSRNOT00000166412.1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      20804173..20958437 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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