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    Pa2g4 proliferation-associated 2G4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 288778, updated on 9-Dec-2024

    Summary

    Official Symbol
    Pa2g4provided by RGD
    Official Full Name
    proliferation-associated 2G4provided by RGD
    Primary source
    RGD:1302994
    See related
    EnsemblRapid:ENSRNOG00000004904 AllianceGenome:RGD:1302994
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ebp1
    Summary
    Predicted to enable nucleic acid binding activity; transcription corepressor activity; and ubiquitin protein ligase binding activity. Involved in negative regulation of apoptotic process and positive regulation of cell differentiation. Located in cytoplasm and nucleolus. Orthologous to human PA2G4 (proliferation-associated 2G4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 511.7), Spleen (RPKM 390.4) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Pa2g4 in Genome Data Viewer
    Location:
    7q11
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (1569326..1576794, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (984795..992264, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (2979587..2987055, complement)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene zinc finger CCCH type containing 10 Neighboring gene ribosomal protein L41 Neighboring gene erb-b2 receptor tyrosine kinase 3 Neighboring gene ribosomal protein S27a, pseudogene 11

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    General gene information

    Clone Names

    • MGC94070

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA binding  
    enables nucleic acid binding  
    enables protein binding PubMed 
    enables transcription corepressor activity  
    enables ubiquitin protein ligase binding  
    Component Evidence Code Pubs
    located_in cytoplasm PubMed 
    located_in cytoplasm  
    located_in nucleolus PubMed 
    located_in nucleolus  
    located_in nucleus  
    part_of ribonucleoprotein complex  

    General protein information

    Preferred Names
    proliferation-associated protein 2G4
    Names
    ErbB3-binding protein 1
    proliferation-associated 2G4, 38kDa

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001004206.1NP_001004206.1  proliferation-associated protein 2G4

      See identical proteins and their annotated locations for NP_001004206.1

      Status: PROVISIONAL

      Source sequence(s)
      BC079095
      UniProtKB/Swiss-Prot
      Q6AYD3
      UniProtKB/TrEMBL
      A0A8L2UI00
      Related
      ENSRNOP00000006578.6, ENSRNOT00000006578.7
      Conserved Domains (1) summary
      TIGR00495
      Location:1388
      crvDNA_42K; 42K curved DNA binding protein

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      1569326..1576794 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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