Ankrd11 ankyrin repeat domain containing 11 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ankrd11provided by RGD
Official Full Name: ankyrin repeat domain containing 11provided by RGD
Primary source: RGD:1306679
See related: EnsemblRapid:ENSRNOG00000027906 AllianceGenome:RGD:1306679
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable protein homodimerization activity. Predicted to be involved in anatomical structure morphogenesis. Predicted to act upstream of or within several processes, including face morphogenesis; skeletal system development; and social behavior. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in chromatin. Human ortholog(s) of this gene implicated in KBG syndrome. Orthologous to human ANKRD11 (ankyrin repeat domain containing 11). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 150.0), Adrenal (RPKM 148.2) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 19q12

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	19	NC_086037.1 (67848836..68007491, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	19	NC_051354.1 (50940284..51098962, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	19	NC_005118.4 (55703831..55862446, complement)

Chromosome 19 - NC_086037.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

BE097847 (e-PCR)
- UniSTS:244766

BE105814 (e-PCR)
- UniSTS:245915

BE105999 (e-PCR)
- UniSTS:245939

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in anatomical structure morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in biological_process	ND No biological Data available more info
acts_upstream_of_or_within bone development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cognition	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within face development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within face morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within gene expression	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within head development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within head morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within in utero embryonic development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within localization of cell	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within multicellular organism growth	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neural precursor cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neurogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within odontogenesis of dentin-containing tooth	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within ossification	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within proteasomal protein catabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein acetylation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein catabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within roof of mouth development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within skeletal system morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within social behavior	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within tissue homeostasis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in chromatin	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: ankyrin repeat domain-containing protein 11

Names: ankyrin repeat domain 11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001374009.1 → NP_001360938.1 ankyrin repeat domain-containing protein 11

Status: VALIDATED

Source sequence(s)

CA504097, JAXUCZ010000019

UniProtKB/TrEMBL

A0A8I6AA00, A0A8I6G4N3

Related

ENSRNOP00000090403.1, ENSRNOT00000113041.2

Conserved Domains (4) summary

PTZ00121
Location:732 → 1634

PTZ00121; MAEBL; Provisional

PHA03247
Location:1858 → 2369

PHA03247; large tegument protein UL36; Provisional

sd00045
Location:167 → 198

ANK; ANK repeat [structural motif]

pfam12796
Location:172 → 264

Ank_2; Ankyrin repeats (3 copies)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086037.1 Reference GRCr8

Range

67848836..68007491 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_008772667.4 → XP_008770889.1 ankyrin repeat domain-containing protein 11 isoform X1

See identical proteins and their annotated locations for XP_008770889.1

UniProtKB/TrEMBL

A0A8I6G4N3

Conserved Domains (4) summary

cd00204
Location:161 → 283

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam12796
Location:171 → 263

Ank_2; Ankyrin repeats (3 copies)

pfam15822
Location:1819 → 2029

MISS; MAPK-interacting and spindle-stabilizing protein-like

sd00045
Location:166 → 197

ANK; ANK repeat [structural motif]
XM_063278178.1 → XP_063134248.1 ankyrin repeat domain-containing protein 11 isoform X2

UniProtKB/TrEMBL

A0A8I5ZRF5, D3ZSU6

Related

ENSRNOP00000035742.6, ENSRNOT00000031389.9
XM_039097915.2 → XP_038953843.1 ankyrin repeat domain-containing protein 11 isoform X3

UniProtKB/TrEMBL

A0A8I6G4N3

Conserved Domains (4) summary

PTZ00121
Location:572 → 1474

PTZ00121; MAEBL; Provisional

PHA03247
Location:1698 → 2209

PHA03247; large tegument protein UL36; Provisional

sd00045
Location:41 → 71

ANK; ANK repeat [structural motif]

pfam12796
Location:45 → 127

Ank_2; Ankyrin repeats (3 copies)
XM_039097914.2 → XP_038953842.1 ankyrin repeat domain-containing protein 11 isoform X3

UniProtKB/TrEMBL

A0A8I6G4N3

Conserved Domains (4) summary

PTZ00121
Location:572 → 1474

PTZ00121; MAEBL; Provisional

PHA03247
Location:1698 → 2209

PHA03247; large tegument protein UL36; Provisional

sd00045
Location:41 → 71

ANK; ANK repeat [structural motif]

pfam12796
Location:45 → 127

Ank_2; Ankyrin repeats (3 copies)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001108900.1: Suppressed sequence

Description

NM_001108900.1: This RefSeq was suppressed temporarily based on the calculation that the encoded protein was shorter than proteins from the putative ortholog from human: ANKRD11 (GeneID:29123).