U.S. flag

An official website of the United States government

Links from GEO Profiles

    • Showing Current items.

    Magi1 membrane associated guanylate kinase, WW and PDZ domain containing 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 500261, updated on 9-Dec-2024

    Summary

    Official Symbol
    Magi1provided by RGD
    Official Full Name
    membrane associated guanylate kinase, WW and PDZ domain containing 1provided by RGD
    Primary source
    RGD:1586025
    See related
    EnsemblRapid:ENSRNOG00000022060 AllianceGenome:RGD:1586025
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    BAP-1; Baiap1; MAGI-1
    Summary
    Predicted to enable alpha-actinin binding activity. Predicted to be involved in endothelial cell morphogenesis; positive regulation of cell-cell adhesion; and signal transduction. Predicted to be located in several cellular components, including adherens junction; nuclear lumen; and plasma membrane. Predicted to be active in cell-cell junction and cytoplasm. Orthologous to human MAGI1 (membrane associated guanylate kinase, WW and PDZ domain containing 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 115.8), Lung (RPKM 114.1) and 9 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Magi1 in Genome Data Viewer
    Location:
    4q34
    Exon count:
    32
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (127762590..128368228, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (126205663..126811354, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (125684816..126300013, complement)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA17 Neighboring gene ribosomal protein lateral stalk subunit P0, pseudogene 15 Neighboring gene uncharacterized LOC134486617 Neighboring gene transfer RNA threonine (anticodon AGU) 30 Neighboring gene small nucleolar RNA SNORA44 Neighboring gene GABA type A receptor-associated protein, pseudogene 3 Neighboring gene dynein light chain LC8-type 1 like 1 Neighboring gene uncharacterized LOC120102497 Neighboring gene elongin B, pseduogene 12 Neighboring gene single stranded DNA binding protein 1, pseudogene 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding  
    enables alpha-actinin binding  
    enables alpha-actinin binding  
    Process Evidence Code Pubs
    involved_in endothelial cell morphogenesis  
    involved_in endothelial cell morphogenesis  
    involved_in endothelial cell morphogenesis  
    involved_in positive regulation of cell-cell adhesion  
    involved_in positive regulation of cell-cell adhesion  
    involved_in signal transduction  
    Items 1 - 20 of 22
    Component Evidence Code Pubs
    located_in adherens junction  
    located_in adherens junction  
    located_in adherens junction  
    located_in bicellular tight junction  
    located_in cell junction  
    located_in cell periphery  
    located_in cell projection  
    located_in cell projection  
    is_active_in cell-cell junction  
    located_in cell-cell junction  
    is_active_in cytoplasm  
    located_in cytoplasm  
    located_in cytoplasm  
    located_in membrane  
    located_in membrane  
    located_in nucleolus  
    located_in nucleolus  
    located_in nucleoplasm  
    located_in nucleoplasm  
    located_in nucleus  
    located_in plasma membrane  
    located_in plasma membrane  
    Items 1 - 20 of 22

    General protein information

    Preferred Names
    membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1
    Names
    BAI1-associated protein 1
    membrane-associated guanylate kinase inverted 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001030045.2 → NP_001025216.2  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/Swiss-Prot
      Q4L1J4, Q4L1J5
    2. NM_001401825.1 → NP_001388754.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/TrEMBL
      A0A0G2JZE4
      Related
      ENSRNOP00000100639.1, ENSRNOT00000133320.1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      127762590..128368228 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006236927.5 → XP_006236989.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X2

      UniProtKB/TrEMBL
      A0A0G2JZE4
      Related
      ENSRNOP00000065881.4, ENSRNOT00000071315.5
      Conserved Domains (6) summary
      smart00228
      Location:1151 → 1233
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00201
      Location:303 → 332
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      cd00992
      Location:995 → 1090
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00397
      Location:361 → 390
      WW; WW domain
      pfam16666
      Location:721 → 804
      MAGI_u5; Unstructured region on MAGI
      cl17190
      Location:122 → 293
      NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
    2. XM_039108183.2 → XP_038964111.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X22

      UniProtKB/TrEMBL
      A0A8I6ABL7
      Related
      ENSRNOP00000033083.8, ENSRNOT00000037848.8
      Conserved Domains (6) summary
      smart00456
      Location:361 → 392
      WW; Domain with 2 conserved Trp (W) residues
      smart00228
      Location:1151 → 1233
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00201
      Location:303 → 332
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      cd00992
      Location:995 → 1090
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam16666
      Location:723 → 805
      MAGI_u5; Unstructured region on MAGI
      cl17190
      Location:122 → 293
      NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
    3. XM_039108192.2 → XP_038964120.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X40

      UniProtKB/TrEMBL
      A0A8I5Y118
      Conserved Domains (6) summary
      smart00456
      Location:349 → 380
      WW; Domain with 2 conserved Trp (W) residues
      smart00228
      Location:1042 → 1124
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:805 → 880
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00397
      Location:302 → 331
      WW; WW domain
      pfam16666
      Location:711 → 798
      MAGI_u5; Unstructured region on MAGI
      cl17190
      Location:122 → 293
      NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
    4. XM_063286549.1 → XP_063142619.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X25

      UniProtKB/TrEMBL
      A0A8I6ABL7
    5. XM_039108195.2 → XP_038964123.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X44

      UniProtKB/TrEMBL
      A0A8I6ABL7
      Conserved Domains (6) summary
      smart00456
      Location:349 → 380
      WW; Domain with 2 conserved Trp (W) residues
      smart00228
      Location:1110 → 1192
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00201
      Location:303 → 332
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      cd00992
      Location:955 → 1049
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam16666
      Location:711 → 799
      MAGI_u5; Unstructured region on MAGI
      cl17190
      Location:122 → 293
      NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
    6. XM_039108194.2 → XP_038964122.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X43

      UniProtKB/TrEMBL
      A0A8I6ABL7
      Conserved Domains (6) summary
      smart00456
      Location:349 → 380
      WW; Domain with 2 conserved Trp (W) residues
      smart00228
      Location:1138 → 1220
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00201
      Location:303 → 332
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      cd00992
      Location:983 → 1077
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam16666
      Location:711 → 793
      MAGI_u5; Unstructured region on MAGI
      cl17190
      Location:122 → 293
      NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
    7. XM_063286563.1 → XP_063142633.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X38

      UniProtKB/TrEMBL
      A0A8I6ABL7
    8. XM_039108184.2 → XP_038964112.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X24

      UniProtKB/TrEMBL
      A0A8I6ABL7
      Conserved Domains (6) summary
      smart00456
      Location:361 → 392
      WW; Domain with 2 conserved Trp (W) residues
      smart00228
      Location:1150 → 1232
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00201
      Location:303 → 332
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      cd00992
      Location:995 → 1089
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam16666
      Location:723 → 805
      MAGI_u5; Unstructured region on MAGI
      cl17190
      Location:122 → 293
      NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
    9. XM_063286565.1 → XP_063142635.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X39

      UniProtKB/TrEMBL
      A0A8I5Y118
    10. XM_063286557.1 → XP_063142627.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X31

      UniProtKB/TrEMBL
      A0A8I6ABL7
    11. XM_063286562.1 → XP_063142632.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X37

      UniProtKB/TrEMBL
      A0A8I6ABL7
    12. XM_063286550.1 → XP_063142620.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X26

      UniProtKB/TrEMBL
      A0A8I6ABL7
    13. XM_063286548.1 → XP_063142618.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X23

      UniProtKB/TrEMBL
      A0A8I6ABL7
    14. XM_039108182.2 → XP_038964110.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X21

      UniProtKB/TrEMBL
      A0A8I6ABL7
      Conserved Domains (6) summary
      smart00456
      Location:362 → 393
      WW; Domain with 2 conserved Trp (W) residues
      smart00228
      Location:1152 → 1234
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00201
      Location:303 → 332
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      cd00992
      Location:996 → 1091
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam16666
      Location:724 → 806
      MAGI_u5; Unstructured region on MAGI
      cl17190
      Location:122 → 293
      NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
    15. XM_063286541.1 → XP_063142611.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X6

      UniProtKB/TrEMBL
      A0A0G2JZE4
    16. XM_039108176.2 → XP_038964104.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X5

      UniProtKB/TrEMBL
      A0A0G2JZE4
      Conserved Domains (6) summary
      smart00456
      Location:361 → 392
      WW; Domain with 2 conserved Trp (W) residues
      smart00228
      Location:1150 → 1232
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:994 → 1089
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00397
      Location:302 → 331
      WW; WW domain
      pfam16666
      Location:723 → 804
      MAGI_u5; Unstructured region on MAGI
      cl17190
      Location:122 → 293
      NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
    17. XM_063286551.1 → XP_063142621.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X27

      UniProtKB/TrEMBL
      A0A8I6ABL7
    18. XM_039108175.2 → XP_038964103.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X4

      UniProtKB/TrEMBL
      A0A0G2JZE4
      Conserved Domains (6) summary
      smart00456
      Location:362 → 393
      WW; Domain with 2 conserved Trp (W) residues
      smart00228
      Location:1151 → 1233
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:995 → 1090
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00397
      Location:302 → 331
      WW; WW domain
      pfam16666
      Location:724 → 805
      MAGI_u5; Unstructured region on MAGI
      cl17190
      Location:122 → 293
      NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
    19. XM_039108193.2 → XP_038964121.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X16

      UniProtKB/TrEMBL
      A0A0G2JZE4
      Conserved Domains (6) summary
      smart00456
      Location:349 → 380
      WW; Domain with 2 conserved Trp (W) residues
      smart00228
      Location:1110 → 1192
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:955 → 1049
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00397
      Location:302 → 331
      WW; WW domain
      pfam16666
      Location:711 → 799
      MAGI_u5; Unstructured region on MAGI
      cl17190
      Location:122 → 293
      NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
    20. XM_063286543.1 → XP_063142613.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X14

      UniProtKB/TrEMBL
      A0A0G2JZE4
    21. XM_006236929.5 → XP_006236991.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X9

      UniProtKB/TrEMBL
      A0A0G2JZE4
      Conserved Domains (6) summary
      smart00228
      Location:1138 → 1220
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00201
      Location:303 → 332
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      cd00992
      Location:983 → 1077
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00397
      Location:349 → 378
      WW; WW domain
      pfam16666
      Location:709 → 792
      MAGI_u5; Unstructured region on MAGI
      cl17190
      Location:122 → 293
      NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
    22. XM_039108177.2 → XP_038964105.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X8

      UniProtKB/TrEMBL
      A0A0G2JZE4
      Conserved Domains (6) summary
      smart00456
      Location:349 → 380
      WW; Domain with 2 conserved Trp (W) residues
      smart00228
      Location:1139 → 1221
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:983 → 1078
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00397
      Location:302 → 331
      WW; WW domain
      pfam16666
      Location:711 → 793
      MAGI_u5; Unstructured region on MAGI
      cl17190
      Location:122 → 293
      NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
    23. XM_063286547.1 → XP_063142617.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X20

      UniProtKB/TrEMBL
      A0A0G2JZE4
    24. XM_063286545.1 → XP_063142615.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X17

      UniProtKB/TrEMBL
      A0A0G2JZE4
    25. XM_063286544.1 → XP_063142614.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X15

      UniProtKB/TrEMBL
      A0A0G2JZE4
    26. XM_008763133.4 → XP_008761355.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X12

      UniProtKB/TrEMBL
      A0A0G2JZE4
      Conserved Domains (6) summary
      smart00228
      Location:1122 → 1204
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00201
      Location:303 → 332
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      cd00992
      Location:967 → 1061
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00397
      Location:361 → 390
      WW; WW domain
      pfam16666
      Location:721 → 804
      MAGI_u5; Unstructured region on MAGI
      cl17190
      Location:122 → 293
      NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
    27. XM_039108179.2 → XP_038964107.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X11

      UniProtKB/TrEMBL
      A0A0G2JZE4, F1M7H7
      Related
      ENSRNOP00000099821.1, ENSRNOT00000164096.1
      Conserved Domains (6) summary
      smart00456
      Location:361 → 392
      WW; Domain with 2 conserved Trp (W) residues
      smart00228
      Location:1123 → 1205
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:967 → 1062
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00397
      Location:302 → 331
      WW; WW domain
      pfam16666
      Location:723 → 811
      MAGI_u5; Unstructured region on MAGI
      cl17190
      Location:122 → 293
      NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
    28. XM_063286546.1 → XP_063142616.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X19

      UniProtKB/TrEMBL
      A0A0G2JZE4
    29. XM_063286542.1 → XP_063142612.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X13

      UniProtKB/TrEMBL
      A0A0G2JZE4
    30. XM_039108178.2 → XP_038964106.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X10

      UniProtKB/TrEMBL
      A0A0G2JZE4
      Conserved Domains (6) summary
      smart00456
      Location:362 → 393
      WW; Domain with 2 conserved Trp (W) residues
      smart00228
      Location:1124 → 1206
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:968 → 1063
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00397
      Location:302 → 331
      WW; WW domain
      pfam16666
      Location:724 → 812
      MAGI_u5; Unstructured region on MAGI
      cl17190
      Location:122 → 293
      NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
    31. XM_039108181.2 → XP_038964109.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X18

      UniProtKB/TrEMBL
      A0A0G2JZE4
      Conserved Domains (6) summary
      smart00456
      Location:362 → 393
      WW; Domain with 2 conserved Trp (W) residues
      smart00228
      Location:1084 → 1166
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:847 → 922
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00397
      Location:302 → 331
      WW; WW domain
      pfam16666
      Location:724 → 806
      MAGI_u5; Unstructured region on MAGI
      cl17190
      Location:122 → 293
      NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
    32. XM_017592832.3 → XP_017448321.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X7

      UniProtKB/TrEMBL
      A0A0G2JZE4
    33. XM_039108174.2 → XP_038964102.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X3

      UniProtKB/TrEMBL
      A0A0G2JZE4
      Conserved Domains (6) summary
      smart00456
      Location:362 → 393
      WW; Domain with 2 conserved Trp (W) residues
      smart00228
      Location:1151 → 1233
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:996 → 1090
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00397
      Location:302 → 331
      WW; WW domain
      pfam16666
      Location:724 → 806
      MAGI_u5; Unstructured region on MAGI
      cl17190
      Location:122 → 293
      NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
    34. XM_039108173.2 → XP_038964101.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JZE4
      Conserved Domains (6) summary
      smart00456
      Location:362 → 393
      WW; Domain with 2 conserved Trp (W) residues
      smart00228
      Location:1152 → 1234
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:996 → 1091
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00397
      Location:302 → 331
      WW; WW domain
      pfam16666
      Location:724 → 806
      MAGI_u5; Unstructured region on MAGI
      cl17190
      Location:122 → 293
      NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
    35. XM_063286554.1 → XP_063142624.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X28

      UniProtKB/TrEMBL
      A0A0G2JZE4
    36. XM_063286553.1 → XP_063142623.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X28

      UniProtKB/TrEMBL
      A0A0G2JZE4
    37. XM_063286552.1 → XP_063142622.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X28

      UniProtKB/TrEMBL
      A0A0G2JZE4
    38. XM_063286567.1 → XP_063142637.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X42

      UniProtKB/TrEMBL
      M0R8T1
    39. XM_063286559.1 → XP_063142629.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X33

      UniProtKB/TrEMBL
      A0A0G2JZE4
    40. XM_063286560.1 → XP_063142630.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X34

      UniProtKB/TrEMBL
      A0A0G2JZE4
    41. XM_039108188.2 → XP_038964116.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X28

      UniProtKB/TrEMBL
      A0A0G2JZE4
      Conserved Domains (7) summary
      smart00456
      Location:135 → 166
      WW; Domain with 2 conserved Trp (W) residues
      smart00228
      Location:925 → 1007
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      PRK12678
      Location:1044 → 1253
      PRK12678; transcription termination factor Rho; Provisional
      cd00992
      Location:769 → 864
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00397
      Location:75 → 104
      WW; WW domain
      pfam16663
      Location:1 → 33
      MAGI_u1; Unstructured region on MAGI
      pfam16666
      Location:497 → 579
      MAGI_u5; Unstructured region on MAGI
    42. XM_063286566.1 → XP_063142636.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X41

      UniProtKB/TrEMBL
      M0R8T1
    43. XM_063286555.1 → XP_063142625.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X29

      UniProtKB/TrEMBL
      A0A0G2JZE4
    44. XM_039108191.2 → XP_038964119.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X28

      UniProtKB/TrEMBL
      A0A0G2JZE4
      Conserved Domains (7) summary
      smart00456
      Location:135 → 166
      WW; Domain with 2 conserved Trp (W) residues
      smart00228
      Location:925 → 1007
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      PRK12678
      Location:1044 → 1253
      PRK12678; transcription termination factor Rho; Provisional
      cd00992
      Location:769 → 864
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00397
      Location:75 → 104
      WW; WW domain
      pfam16663
      Location:1 → 33
      MAGI_u1; Unstructured region on MAGI
      pfam16666
      Location:497 → 579
      MAGI_u5; Unstructured region on MAGI
    45. XM_063286556.1 → XP_063142626.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X30

      UniProtKB/TrEMBL
      A0A0G2JZE4
    46. XM_039108185.2 → XP_038964113.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X28

      UniProtKB/TrEMBL
      A0A0G2JZE4
      Conserved Domains (7) summary
      smart00456
      Location:135 → 166
      WW; Domain with 2 conserved Trp (W) residues
      smart00228
      Location:925 → 1007
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      PRK12678
      Location:1044 → 1253
      PRK12678; transcription termination factor Rho; Provisional
      cd00992
      Location:769 → 864
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00397
      Location:75 → 104
      WW; WW domain
      pfam16663
      Location:1 → 33
      MAGI_u1; Unstructured region on MAGI
      pfam16666
      Location:497 → 579
      MAGI_u5; Unstructured region on MAGI
    47. XM_063286561.1 → XP_063142631.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X36

      UniProtKB/Swiss-Prot
      Q4L1J4, Q4L1J5
    48. XM_063286558.1 → XP_063142628.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X32

      UniProtKB/Swiss-Prot
      Q4L1J4, Q4L1J5
    49. XM_039108189.2 → XP_038964117.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X35

      UniProtKB/Swiss-Prot
      Q4L1J4, Q4L1J5
      Conserved Domains (6) summary
      smart00456
      Location:361 → 392
      WW; Domain with 2 conserved Trp (W) residues
      smart00228
      Location:1123 → 1205
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:967 → 1062
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00397
      Location:302 → 331
      WW; WW domain
      pfam16666
      Location:723 → 811
      MAGI_u5; Unstructured region on MAGI
      cl17190
      Location:122 → 293
      NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
    External link. Please review our privacy policy.