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    Gpr34 G protein-coupled receptor 34 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 554353, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Gpr34provided by RGD
    Official Full Name
    G protein-coupled receptor 34provided by RGD
    Primary source
    RGD:1563681
    See related
    EnsemblRapid:ENSRNOG00000039759 AllianceGenome:RGD:1563681
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable G protein-coupled purinergic nucleotide receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to be located in plasma membrane. Orthologous to human GPR34 (G protein-coupled receptor 34). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 44.7), Spleen (RPKM 39.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Gpr34 in Genome Data Viewer
    Location:
    Xq12
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (11777667..11786640, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (9104829..9113796, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (10022986..10043504, complement)

    Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene transfer RNA glutamine (anticodon UUG) 5 Neighboring gene calcium/calmodulin dependent serine protein kinase Neighboring gene G protein-coupled receptor 82 Neighboring gene uncharacterized LOC120099226 Neighboring gene transfer RNA aspartic acid (anticodon GUC) 13

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Identification of a lysophosphatidylserine receptor on mast cells. Sugo T, et al. Biochem Biophys Res Commun, 2006 Mar 24. PMID 16460680
    2. GPR34 is a receptor for lysophosphatidylserine with a fatty acid at the sn-2 position. Kitamura H, et al. J Biochem, 2012 May. PMID 22343749
    3. Interaction of the plasma membrane Ca2+ pump 4b/CI with the Ca2+/calmodulin-dependent membrane-associated kinase CASK. Schuh K, et al. J Biol Chem, 2003 Mar 14. PMID 12511555
    4. The structural evolution of a P2Y-like G-protein-coupled receptor. Schulz A, et al. J Biol Chem, 2003 Sep 12. PMID 12835326
    5. A multiprotein trafficking complex composed of SAP97, CASK, Veli, and Mint1 is associated with inward rectifier Kir2 potassium channels. Leonoudakis D, et al. J Biol Chem, 2004 Apr 30. PMID 14960569

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The present studies confirm that GPR34 is a cellular receptor for LysoPS, especially with a fatty acid at the sn-2 position.
      Title: GPR34 is a receptor for lysophosphatidylserine with a fatty acid at the sn-2 position.
    2. results suggest that GPR34 is the functional mast cell lysophosphatidylserine receptor
      Title: Identification of a lysophosphatidylserine receptor on mast cells.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables G protein-coupled purinergic nucleotide receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled purinergic nucleotide receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    probable G-protein coupled receptor 34

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001024925.2 → NP_001020096.1  probable G-protein coupled receptor 34

      See identical proteins and their annotated locations for NP_001020096.1

      Status: PROVISIONAL

      Source sequence(s)
      AB159443
      UniProtKB/TrEMBL
      A0A8I6AI22, A6JZX9, Q6XCE7
      Conserved Domains (1) summary
      cd15148
      Location:47 → 330
      7tmA_GPR34-like; putative G protein-coupled receptor 34, member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086039.1 Reference GRCr8

      Range
      11777667..11786640 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006256675.5 → XP_006256737.1  probable G-protein coupled receptor 34 isoform X1

      See identical proteins and their annotated locations for XP_006256737.1

      UniProtKB/TrEMBL
      A0A8I6AI22, A6JZX9, Q6XCE7
      Related
      ENSRNOP00000104305.1, ENSRNOT00000154166.1
      Conserved Domains (1) summary
      cd15148
      Location:47 → 330
      7tmA_GPR34-like; putative G protein-coupled receptor 34, member of the class A family of seven-transmembrane G protein-coupled receptors

    2. XM_039099999.2 → XP_038955927.1  probable G-protein coupled receptor 34 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AI22, A6JZX9, Q6XCE7
      Related
      ENSRNOP00000099378.1, ENSRNOT00000136922.1
      Conserved Domains (1) summary
      cd15148
      Location:47 → 330
      7tmA_GPR34-like; putative G protein-coupled receptor 34, member of the class A family of seven-transmembrane G protein-coupled receptors
    Nucleotide Protein Strain
    Heading Accession and Version

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