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    Men1 menin 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 29417, updated on 9-Dec-2024

    Summary

    Official Symbol
    Men1provided by RGD
    Official Full Name
    menin 1provided by RGD
    Primary source
    RGD:3078
    See related
    EnsemblRapid:ENSRNOG00000021054 AllianceGenome:RGD:3078
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    menin
    Summary
    Enables chromatin binding activity. Involved in several processes, including decidualization; regulation of epithelial cell proliferation; and regulation of transcription by RNA polymerase II. Located in nucleus. Human ortholog(s) of this gene implicated in endocrine gland cancer (multiple); hyperparathyroidism; and multiple endocrine neoplasia type 1. Orthologous to human MEN1 (menin 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 77.4), Adrenal (RPKM 74.1) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Men1 in Genome Data Viewer
    Location:
    1q43
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (213068166..213074132)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (203638905..203644871)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (221704394..221710343)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene EH-domain containing 1 Neighboring gene CDC42 binding protein kinase gamma Neighboring gene uncharacterized LOC134483959 Neighboring gene mitogen activated protein kinase kinase kinase kinase 2 Neighboring gene uncharacterized LOC134483960 Neighboring gene U7 small nuclear RNA Neighboring gene splicing factor 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Clone Names

    • MGC114329

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding  
    enables DNA-binding transcription activator activity  
    enables R-SMAD binding  
    enables R-SMAD binding  
    enables Y-form DNA binding  
    enables Y-form DNA binding  
    enables Y-form DNA binding  
    enables chromatin binding  
    enables chromatin binding PubMed 
    enables chromatin binding  
    enables double-stranded DNA binding  
    enables four-way junction DNA binding  
    enables four-way junction DNA binding  
    enables phosphoprotein binding  
    enables phosphoprotein binding  
    enables protein-macromolecule adaptor activity  
    enables protein-macromolecule adaptor activity  
    enables sequence-specific DNA binding  
    enables transcription cis-regulatory region binding  
    enables transcription cis-regulatory region binding  
    enables transcription cis-regulatory region binding  
    Items 1 - 25 of 78
    Process Evidence Code Pubs
    involved_in DNA damage response  
    involved_in DNA damage response  
    involved_in MAPK cascade  
    involved_in MAPK cascade  
    involved_in T-helper 2 cell differentiation  
    involved_in T-helper 2 cell differentiation  
    acts_upstream_of cell division  
    acts_upstream_of cell population proliferation  
    involved_in cellular response to glucose stimulus PubMed 
    involved_in cellular response to peptide hormone stimulus PubMed 
    acts_upstream_of_or_within chromatin remodeling  
    involved_in decidualization PubMed 
    acts_upstream_of_or_within embryonic skeletal system morphogenesis  
    acts_upstream_of fibroblast apoptotic process  
    acts_upstream_of fibroblast proliferation  
    acts_upstream_of_or_within hemopoiesis  
    acts_upstream_of_or_within leukocyte homeostasis  
    acts_upstream_of_or_within maternal process involved in female pregnancy  
    involved_in negative regulation of DNA-binding transcription factor activity  
    involved_in negative regulation of DNA-templated transcription  
    involved_in negative regulation of JNK cascade  
    involved_in negative regulation of JNK cascade  
    involved_in negative regulation of cell cycle  
    involved_in negative regulation of cell cycle  
    involved_in negative regulation of cell cycle  
    involved_in negative regulation of cell cycle G1/S phase transition PubMed 
    involved_in negative regulation of cell population proliferation  
    involved_in negative regulation of cell population proliferation  
    acts_upstream_of_or_within negative regulation of cell population proliferation  
    involved_in negative regulation of cell population proliferation  
    involved_in negative regulation of cell-substrate adhesion PubMed 
    involved_in negative regulation of cyclin-dependent protein serine/threonine kinase activity  
    involved_in negative regulation of epithelial cell proliferation PubMed 
    acts_upstream_of_or_within negative regulation of fibroblast proliferation  
    acts_upstream_of_or_within negative regulation of organ growth  
    involved_in negative regulation of osteoblast differentiation  
    acts_upstream_of_or_within negative regulation of osteoblast differentiation  
    involved_in negative regulation of protein phosphorylation  
    acts_upstream_of_or_within negative regulation of stem cell proliferation  
    involved_in negative regulation of transcription by RNA polymerase II  
    involved_in negative regulation of transcription by RNA polymerase II PubMed 
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II  
    involved_in negative regulation of transcription by RNA polymerase II  
    acts_upstream_of_or_within negative regulation of type B pancreatic cell proliferation  
    acts_upstream_of organ growth  
    acts_upstream_of_or_within ossification  
    involved_in osteoblast development  
    acts_upstream_of_or_within osteoblast development  
    acts_upstream_of_or_within osteoblast fate commitment  
    acts_upstream_of_or_within positive regulation of DNA-templated transcription  
    acts_upstream_of_or_within positive regulation of cell division  
    acts_upstream_of_or_within positive regulation of fibroblast apoptotic process  
    acts_upstream_of_or_within positive regulation of gene expression  
    acts_upstream_of_or_within positive regulation of osteoblast differentiation  
    acts_upstream_of_or_within positive regulation of stem cell differentiation  
    involved_in positive regulation of transcription by RNA polymerase II  
    involved_in positive regulation of transcription by RNA polymerase II PubMed 
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II  
    involved_in positive regulation of transcription by RNA polymerase II  
    involved_in positive regulation of transforming growth factor beta receptor signaling pathway  
    involved_in positive regulation of transforming growth factor beta receptor signaling pathway  
    acts_upstream_of_or_within regulation of G1/S transition of mitotic cell cycle  
    involved_in regulation of activin receptor signaling pathway PubMed 
    acts_upstream_of_or_within regulation of gene expression  
    involved_in regulation of transcription by RNA polymerase II  
    involved_in regulation of type B pancreatic cell proliferation PubMed 
    involved_in response to UV  
    involved_in response to UV  
    involved_in response to gamma radiation  
    involved_in response to gamma radiation  
    involved_in response to transforming growth factor beta PubMed 
    acts_upstream_of_or_within roof of mouth development  
    acts_upstream_of stem cell differentiation  
    acts_upstream_of stem cell proliferation  
    involved_in transcription initiation-coupled chromatin remodeling  
    involved_in transcription initiation-coupled chromatin remodeling  
    involved_in type B pancreatic cell differentiation PubMed 
    acts_upstream_of type B pancreatic cell proliferation  
    Items 1 - 25 of 78
    Items 1 - 20 of 22
    Component Evidence Code Pubs
    part_of MLL1 complex  
    part_of MLL1 complex  
    part_of MLL1/2 complex  
    located_in chromatin  
    located_in chromatin  
    located_in chromatin  
    located_in chromosome, telomeric region  
    located_in cleavage furrow  
    located_in cleavage furrow  
    located_in cytoplasm  
    located_in cytosol  
    located_in cytosol  
    part_of histone methyltransferase complex  
    part_of histone methyltransferase complex  
    located_in nuclear matrix  
    located_in nuclear matrix  
    located_in nucleoplasm  
    located_in nucleus PubMed 
    located_in nucleus  
    part_of protein-containing complex  
    part_of transcription repressor complex  
    part_of transcription repressor complex  
    Items 1 - 20 of 22

    General protein information

    Preferred Names
    menin
    Names
    multiple endocrine neoplasia 1
    multiple endocrine neoplasia I
    multiple endocrine neoplasia type I

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019208.3NP_062081.1  menin

      See identical proteins and their annotated locations for NP_062081.1

      Status: VALIDATED

      Source sequence(s)
      AF130370, BQ193347, CB773186, CB814296, CV079282
      UniProtKB/Swiss-Prot
      D3ZCA2, Q9WVR8
      UniProtKB/TrEMBL
      A0A8L2QI00
      Related
      ENSRNOP00000076697.1, ENSRNOT00000099846.2
      Conserved Domains (2) summary
      cd14456
      Location:3458
      Menin; Scaffolding protein menin encoded by the MEN1 gene
      pfam05053
      Location:2608
      Menin; Menin

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      213068166..213074132
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039109376.2XP_038965304.1  menin isoform X3

      Conserved Domains (1) summary
      cl27083
      Location:8457
      Menin; Scaffolding protein menin encoded by the MEN1 gene
    2. XM_006230769.5XP_006230831.1  menin isoform X1

      See identical proteins and their annotated locations for XP_006230831.1

      UniProtKB/TrEMBL
      A0A8L2QI00, A6HZG1
      Related
      ENSRNOP00000028592.6, ENSRNOT00000028592.8
      Conserved Domains (2) summary
      cd14456
      Location:9464
      Menin; Scaffolding protein menin encoded by the MEN1 gene
      pfam05053
      Location:8614
      Menin; Menin
    3. XM_006230771.5XP_006230833.1  menin isoform X2

      See identical proteins and their annotated locations for XP_006230833.1

      UniProtKB/Swiss-Prot
      D3ZCA2, Q9WVR8
      UniProtKB/TrEMBL
      A0A8L2QI00
      Conserved Domains (2) summary
      cd14456
      Location:3458
      Menin; Scaffolding protein menin encoded by the MEN1 gene
      pfam05053
      Location:2608
      Menin; Menin
    4. XM_006230772.5XP_006230834.1  menin isoform X2

      See identical proteins and their annotated locations for XP_006230834.1

      UniProtKB/Swiss-Prot
      D3ZCA2, Q9WVR8
      UniProtKB/TrEMBL
      A0A8L2QI00
      Conserved Domains (2) summary
      cd14456
      Location:3458
      Menin; Scaffolding protein menin encoded by the MEN1 gene
      pfam05053
      Location:2608
      Menin; Menin
    5. XM_006230770.5XP_006230832.1  menin isoform X2

      See identical proteins and their annotated locations for XP_006230832.1

      UniProtKB/Swiss-Prot
      D3ZCA2, Q9WVR8
      UniProtKB/TrEMBL
      A0A8L2QI00
      Conserved Domains (2) summary
      cd14456
      Location:3458
      Menin; Scaffolding protein menin encoded by the MEN1 gene
      pfam05053
      Location:2608
      Menin; Menin
    6. XM_063287501.1XP_063143571.1  menin isoform X4

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