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    Map3k7 mitogen activated protein kinase kinase kinase 7 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 313121, updated on 9-Dec-2024

    Summary

    Symbol
    Map3k7provided by RGD
    Full Name
    mitogen activated protein kinase kinase kinase 7provided by RGD
    Primary source
    RGD:1309438
    See related
    EnsemblRapid:ENSRNOG00000005724 AllianceGenome:RGD:1309438
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Tak1
    Summary
    Enables several functions, including ATP binding activity; enzyme binding activity; and protein kinase activity. Involved in several processes, including positive regulation of cell size; positive regulation of intracellular signal transduction; and positive regulation of vascular associated smooth muscle cell migration. Predicted to be located in plasma membrane and postsynaptic density. Predicted to be part of ATAC complex. Predicted to be active in cytosol and endoplasmic reticulum membrane. Used to study arteriosclerosis. Biomarker of chronic kidney disease and myocardial infarction. Human ortholog(s) of this gene implicated in frontometaphyseal dysplasia; frontometaphyseal dysplasia 2; and prostate cancer. Orthologous to human MAP3K7 (mitogen-activated protein kinase kinase kinase 7). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 113.9), Thymus (RPKM 113.1) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Map3k7 in Genome Data Viewer
    Location:
    5q21
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (51149524..51212012)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (46356973..46415597)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (47183142..47244424)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120102848 Neighboring gene uncharacterized LOC108350944 Neighboring gene uncharacterized LOC120103146 Neighboring gene uncharacterized LOC134487062

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding PubMed 
    enables ATP binding  
    enables DNA-binding transcription factor binding PubMed 
    enables JUN kinase kinase kinase activity  
    enables MAP kinase activity  
    enables MAP kinase kinase activity  
    enables MAP kinase kinase kinase activity  
    enables MAP kinase kinase kinase activity PubMed 
    enables MAP kinase kinase kinase activity  
    enables MAP kinase kinase kinase activity  
    enables MAP kinase kinase kinase activity  
    enables MAP kinase kinase kinase kinase activity  
    enables histone kinase activity PubMed 
    enables identical protein binding  
    enables linear polyubiquitin binding  
    enables magnesium ion binding  
    enables protein binding PubMed 
    enables protein serine kinase activity  
    enables protein serine/threonine kinase activity  
    enables protein serine/threonine kinase binding PubMed 
    enables receptor tyrosine kinase binding  
    enables scaffold protein binding  
    enables transcription coactivator binding PubMed 
    enables type II transforming growth factor beta receptor binding PubMed 
    enables ubiquitin protein ligase binding PubMed 
    Items 1 - 25 of 64
    Process Evidence Code Pubs
    acts_upstream_of_or_within I-kappaB phosphorylation  
    involved_in I-kappaB phosphorylation  
    involved_in I-kappaB phosphorylation  
    involved_in JNK cascade  
    acts_upstream_of JNK cascade  
    involved_in JNK cascade  
    involved_in JNK cascade  
    involved_in MAPK cascade PubMed 
    involved_in MAPK cascade  
    acts_upstream_of_or_within MAPK cascade  
    involved_in MAPK cascade  
    acts_upstream_of_or_within angiogenesis  
    involved_in anoikis  
    involved_in apoptotic process  
    acts_upstream_of apoptotic signaling pathway  
    involved_in bone development  
    involved_in canonical NF-kappaB signal transduction  
    involved_in cellular response to angiotensin PubMed 
    involved_in cellular response to hypoxia PubMed 
    involved_in cellular response to transforming growth factor beta stimulus PubMed 
    involved_in cellular response to transforming growth factor beta stimulus PubMed 
    involved_in cellular response to tumor necrosis factor PubMed 
    involved_in chromatin remodeling  
    involved_in defense response to bacterium  
    involved_in immune response  
    involved_in inflammatory response  
    involved_in interleukin-1-mediated signaling pathway  
    involved_in interleukin-17A-mediated signaling pathway  
    involved_in interleukin-33-mediated signaling pathway  
    acts_upstream_of_or_within negative regulation of apoptotic signaling pathway  
    involved_in negative regulation of gene expression PubMed 
    involved_in negative regulation of necroptotic process  
    involved_in negative regulation of reactive oxygen species metabolic process  
    acts_upstream_of_or_within negative regulation of ripoptosome assembly involved in necroptotic process  
    involved_in negative regulation of voltage-gated calcium channel activity PubMed 
    acts_upstream_of_or_within neural tube formation  
    involved_in osteoblast differentiation  
    involved_in p38MAPK cascade  
    acts_upstream_of_or_within positive regulation of JNK cascade  
    involved_in positive regulation of JUN kinase activity  
    involved_in positive regulation of JUN kinase activity  
    involved_in positive regulation of MAPK cascade PubMed 
    involved_in positive regulation of T cell cytokine production  
    involved_in positive regulation of autophagy PubMed 
    involved_in positive regulation of cGAS/STING signaling pathway  
    involved_in positive regulation of canonical NF-kappaB signal transduction  
    involved_in positive regulation of canonical NF-kappaB signal transduction PubMed 
    involved_in positive regulation of canonical NF-kappaB signal transduction  
    involved_in positive regulation of cell cycle PubMed 
    involved_in positive regulation of cell size PubMed 
    involved_in positive regulation of interleukin-2 production  
    involved_in positive regulation of macroautophagy  
    involved_in positive regulation of non-canonical NF-kappaB signal transduction  
    involved_in positive regulation of vascular associated smooth muscle cell migration PubMed 
    involved_in positive regulation of vascular associated smooth muscle cell proliferation PubMed 
    involved_in protein phosphorylation PubMed 
    acts_upstream_of_or_within protein phosphorylation  
    involved_in protein phosphorylation  
    acts_upstream_of_or_within regulation of reactive oxygen species metabolic process  
    involved_in response to angiotensin PubMed 
    involved_in response to hypoxia PubMed 
    involved_in stress-activated MAPK cascade  
    involved_in toll-like receptor 4 signaling pathway  
    acts_upstream_of_or_within transforming growth factor beta receptor signaling pathway  
    Items 1 - 25 of 64
    Component Evidence Code Pubs
    part_of ATAC complex  
    located_in cytoplasm  
    is_active_in cytoplasm  
    is_active_in cytosol  
    located_in cytosol  
    is_active_in endoplasmic reticulum membrane  
    located_in plasma membrane  
    located_in plasma membrane  
    located_in postsynaptic density  

    General protein information

    Preferred Names
    mitogen-activated protein kinase kinase kinase 7
    Names
    TGF-beta activated kinase 1
    mitogen-activated protein kinase kinase kinase 7-like
    NP_001101390.2
    XP_006238028.1
    XP_038965747.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107920.2NP_001101390.2  mitogen-activated protein kinase kinase kinase 7

      See identical proteins and their annotated locations for NP_001101390.2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/Swiss-Prot
      P0C8E4
      UniProtKB/TrEMBL
      A0A8L2Q3A7
      Related
      ENSRNOP00000007654.4, ENSRNOT00000007654.7
      Conserved Domains (1) summary
      cd14058
      Location:42292
      STKc_TAK1; Catalytic domain of the Serine/Threonine Kinase, Transforming Growth Factor beta Activated Kinase-1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      51149524..51212012
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006237966.5XP_006238028.1  mitogen-activated protein kinase kinase kinase 7 isoform X1

      See identical proteins and their annotated locations for XP_006238028.1

      UniProtKB/TrEMBL
      A0A8I6GA73, A0A8L2Q3A7
      Related
      ENSRNOP00000083011.1, ENSRNOT00000098749.2
      Conserved Domains (2) summary
      smart00219
      Location:36284
      TyrKc; Tyrosine kinase, catalytic domain
      cd14058
      Location:42292
      STKc_TAK1; Catalytic domain of the Serine/Threonine Kinase, Transforming Growth Factor beta Activated Kinase-1
    2. XM_039109819.2XP_038965747.1  mitogen-activated protein kinase kinase kinase 7 isoform X2

      Conserved Domains (1) summary
      cd14058
      Location:42292
      STKc_TAK1; Catalytic domain of the Serine/Threonine Kinase, Transforming Growth Factor beta Activated Kinase-1
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