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    Enpp1 ectonucleotide pyrophosphatase/phosphodiesterase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 85496, updated on 4-Jan-2025

    Summary

    Official Symbol
    Enpp1provided by RGD
    Official Full Name
    ectonucleotide pyrophosphatase/phosphodiesterase 1provided by RGD
    Primary source
    RGD:628825
    See related
    EnsemblRapid:ENSRNOG00000013994 AllianceGenome:RGD:628825
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Pc1; Npps
    Summary
    Enables phosphodiesterase I activity. Involved in several processes, including brain development; cellular response to cAMP; and cellular response to mechanical stimulus. Located in dendrite; neuronal cell body; and plasma membrane. Biomarker of aortic valve disease 1. Human ortholog(s) of this gene implicated in several diseases, including arterial calcification of infancy; end stage renal disease; obesity; ossification of the posterior longitudinal ligament of spine; and type 2 diabetes mellitus. Orthologous to human ENPP1 (ectonucleotide pyrophosphatase/phosphodiesterase 1). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in Kidney (RPKM 90.9), Liver (RPKM 89.9) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Enpp1 in Genome Data Viewer
    Location:
    1p12
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (22518051..22583044)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (20698746..20763741)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (21748201..21813205)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120098836 Neighboring gene ectonucleotide pyrophosphatase/phosphodiesterase 3 Neighboring gene uncharacterized LOC102553363 Neighboring gene uncharacterized LOC134484968 Neighboring gene uncharacterized LOC102553457 Neighboring gene cellular communication network factor 2 Neighboring gene uncharacterized LOC134484969

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by RGD

    Items 1 - 25 of 34
    Function Evidence Code Pubs
    enables 3',5'-cyclic-AMP phosphodiesterase activity  
    enables 8-oxo-(d)RTP hydrolase activity  
    enables ATP binding  
    enables ATP diphosphatase activity  
    enables GTP diphosphatase activity  
    enables UTP diphosphatase activity  
    enables calcium ion binding  
    enables calcium ion binding  
    enables cyclic-GMP-AMP hydrolase activity  
    enables cyclic-GMP-AMP hydrolase activity  
    enables dinucleotide phosphatase activity  
    enables dinucleotide phosphatase activity  
    enables dinucleotide phosphatase activity  
    enables exonuclease activity  
    enables hydrolase activity, acting on ester bonds  
    enables identical protein binding  
    enables insulin receptor binding  
    enables metal ion binding  
    enables nucleic acid binding  
    enables nucleoside triphosphate diphosphatase activity  
    enables nucleoside triphosphate diphosphatase activity  
    enables phosphatase activity  
    enables phosphodiesterase I activity  
    enables phosphodiesterase I activity PubMed 
    enables phosphodiesterase I activity  
    enables phosphodiesterase I activity  
    enables phosphoric diester hydrolase activity  
    enables polysaccharide binding  
    enables protein homodimerization activity  
    enables protein homodimerization activity  
    enables pyrophosphatase activity  
    enables scavenger receptor activity  
    enables zinc ion binding  
    enables zinc ion binding  
    Items 1 - 25 of 34
    Items 1 - 25 of 138
    Process Evidence Code Pubs
    involved_in 3'-phosphoadenosine 5'-phosphosulfate metabolic process  
    involved_in ATP metabolic process  
    involved_in ATP metabolic process  
    involved_in ATP metabolic process  
    involved_in B-1 B cell homeostasis  
    involved_in D-glucose import  
    involved_in T cell differentiation  
    involved_in Wnt signaling pathway  
    involved_in adipose tissue development  
    involved_in adult locomotory behavior  
    involved_in adult walking behavior  
    involved_in aorta development  
    involved_in apoptotic process involved in development  
    involved_in artery development  
    involved_in articular cartilage development  
    involved_in axon regeneration  
    involved_in biomineral tissue development  
    involved_in bone development  
    involved_in bone growth  
    acts_upstream_of bone mineralization  
    involved_in bone mineralization  
    involved_in bone mineralization involved in bone maturation  
    acts_upstream_of_or_within bone remodeling  
    involved_in bone remodeling  
    involved_in bone resorption  
    involved_in bone trabecula formation  
    involved_in calcium ion homeostasis  
    involved_in cartilage development  
    acts_upstream_of_positive_effect cell morphogenesis  
    involved_in cell population proliferation  
    involved_in cellular homeostasis  
    involved_in cellular response to acidic pH PubMed 
    involved_in cellular response to cAMP PubMed 
    involved_in cellular response to insulin stimulus  
    involved_in cellular response to mechanical stimulus PubMed 
    involved_in cellular response to sodium phosphate  
    involved_in cellular response to transforming growth factor beta stimulus PubMed 
    involved_in cementum mineralization  
    involved_in central nervous system myelination  
    involved_in cerebellum development PubMed 
    involved_in cerebral cortex development PubMed 
    involved_in collagen-activated signaling pathway  
    involved_in defense response to protozoan  
    involved_in determination of adult lifespan  
    involved_in diphosphate metabolic process  
    involved_in endochondral bone morphogenesis  
    involved_in endochondral ossification  
    involved_in establishment of localization in cell  
    involved_in fat cell differentiation  
    involved_in fat pad development  
    involved_in fatty acid metabolic process  
    involved_in fibroblast growth factor receptor signaling pathway  
    acts_upstream_of_positive_effect gene expression  
    involved_in gene expression  
    involved_in generation of precursor metabolites and energy  
    involved_in glucose homeostasis  
    involved_in glycolytic process  
    involved_in heart development  
    involved_in hematopoietic stem cell migration to bone marrow  
    involved_in hippocampus development PubMed 
    involved_in hormone metabolic process  
    involved_in immune response  
    involved_in inflammatory response to antigenic stimulus  
    involved_in inhibition of non-skeletal tissue mineralization  
    involved_in inorganic diphosphate transport  
    involved_in inorganic diphosphate transport  
    involved_in intracellular phosphate ion homeostasis  
    involved_in kidney development  
    involved_in leukocyte activation involved in inflammatory response  
    involved_in ligamentous ossification  
    involved_in liver development PubMed 
    involved_in long-term synaptic potentiation  
    involved_in mRNA transcription by RNA polymerase II  
    involved_in macrophage differentiation  
    involved_in magnesium ion homeostasis  
    involved_in melanocyte differentiation  
    involved_in melanocyte differentiation  
    involved_in microglia differentiation  
    involved_in microglial cell migration  
    involved_in middle ear morphogenesis  
    involved_in mitochondrion organization  
    involved_in morphogenesis of an epithelium  
    involved_in mucus secretion  
    involved_in multicellular organism growth  
    involved_in muscle cell cellular homeostasis  
    involved_in negative regulation of D-glucose import  
    involved_in negative regulation of bone mineralization  
    involved_in negative regulation of bone mineralization  
    involved_in negative regulation of cell growth  
    involved_in negative regulation of fat cell differentiation  
    involved_in negative regulation of fat cell differentiation  
    involved_in negative regulation of glycogen biosynthetic process  
    involved_in negative regulation of hh target transcription factor activity  
    involved_in negative regulation of hh target transcription factor activity  
    involved_in negative regulation of insulin receptor signaling pathway  
    acts_upstream_of_or_within negative regulation of ossification  
    involved_in negative regulation of protein autophosphorylation  
    involved_in neuron apoptotic process  
    involved_in nucleoside triphosphate catabolic process  
    involved_in nucleoside triphosphate catabolic process  
    involved_in odontogenesis  
    involved_in olfactory bulb development PubMed 
    involved_in oligodendrocyte apoptotic process  
    involved_in organic phosphonate metabolic process  
    acts_upstream_of ossification  
    involved_in ossification  
    involved_in osteoblast differentiation  
    involved_in osteoclast differentiation  
    involved_in phosphate ion homeostasis  
    involved_in phosphate-containing compound metabolic process  
    involved_in plasma cell differentiation  
    involved_in post-embryonic forelimb morphogenesis  
    acts_upstream_of_or_within_negative_effect protein poly-ADP-ribosylation  
    involved_in regulation of bone mineralization  
    involved_in response to ATP  
    involved_in response to Gram-positive bacterium  
    involved_in response to dietary excess  
    involved_in response to insulin  
    involved_in response to magnesium ion  
    involved_in response to mechanical stimulus PubMed 
    involved_in response to platelet-derived growth factor  
    involved_in response to sodium phosphate  
    involved_in response to vitamin B6  
    involved_in response to wounding  
    involved_in sensory perception of mechanical stimulus  
    involved_in sensory perception of sound  
    involved_in sensory perception of temperature stimulus  
    involved_in sequestering of triglyceride  
    involved_in skin development  
    involved_in smoothened signaling pathway  
    involved_in spinal cord development  
    involved_in striatum development PubMed 
    involved_in tooth mineralization  
    involved_in vascular associated smooth muscle cell migration  
    involved_in vascular associated smooth muscle cell proliferation  
    involved_in vasculogenesis  
    involved_in vesicle-mediated transport  
    involved_in vitamin D3 metabolic process  
    Items 1 - 25 of 138
    Component Evidence Code Pubs
    located_in apical dendrite PubMed 
    located_in basal dendrite PubMed 
    located_in basolateral plasma membrane  
    located_in cell body PubMed 
    located_in cell projection PubMed 
    is_active_in cell surface  
    is_active_in cell surface  
    located_in cell surface  
    located_in extracellular region  
    is_active_in extracellular region  
    located_in extracellular space  
    located_in membrane  
    located_in membrane  
    located_in neuronal cell body PubMed 
    located_in plasma membrane PubMed 
    is_active_in plasma membrane  
    located_in plasma membrane  
    located_in plasma membrane  

    General protein information

    Preferred Names
    ectonucleotide pyrophosphatase/phosphodiesterase family member 1
    Names
    E-NPP 1
    NPPase
    alkaline phosphodiesterase I
    nucleotide diphosphatase
    nucleotide pyrophosphatase
    phosphodiesterase I/nucleotide pyrophosphatase 1
    plasma-cell membrane glycoprotein PC-1
    NP_445987.2
    XP_006227754.1
    XP_038948891.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053535.2NP_445987.2  ectonucleotide pyrophosphatase/phosphodiesterase family member 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/Swiss-Prot
      Q91XQ3, Q920C8, Q924C3
      UniProtKB/TrEMBL
      A6JUK6, G3V7V4
      Related
      ENSRNOP00000019519.6, ENSRNOT00000019519.8

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      22518051..22583044
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006227692.4XP_006227754.1  ectonucleotide pyrophosphatase/phosphodiesterase family member 1 isoform X1

      UniProtKB/Swiss-Prot
      Q91XQ3, Q920C8, Q924C3
      Conserved Domains (4) summary
      smart00201
      Location:86126
      SO; Somatomedin B -like domains
      smart00477
      Location:656887
      NUC; DNA/RNA non-specific endonuclease
      pfam01663
      Location:194520
      Phosphodiest; Type I phosphodiesterase / nucleotide pyrophosphatase
      cd16018
      Location:192560
      Enpp; Ectonucleotide pyrophosphatase/phosphodiesterase, also called autotaxin
    2. XM_039092963.2XP_038948891.1  ectonucleotide pyrophosphatase/phosphodiesterase family member 1 isoform X2

      UniProtKB/TrEMBL
      A6JUK7
      Conserved Domains (2) summary
      smart00477
      Location:305536
      NUC; DNA/RNA non-specific endonuclease
      pfam01663
      Location:3168
      Phosphodiest; Type I phosphodiesterase / nucleotide pyrophosphatase
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