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    Hnrnpf heterogeneous nuclear ribonucleoprotein F [ Rattus norvegicus (Norway rat) ]

    Gene ID: 64200, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Hnrnpfprovided by RGD
    Official Full Name
    heterogeneous nuclear ribonucleoprotein Fprovided by RGD
    Primary source
    RGD:620366
    See related
    EnsemblRapid:ENSRNOG00000014562 AllianceGenome:RGD:620366
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Hnrpf
    Summary
    Enables TBP-class protein binding activity. Predicted to be involved in regulation of RNA splicing. Predicted to be located in cytosol. Predicted to be part of catalytic step 2 spliceosome. Predicted to be active in nucleoplasm and synapse. Orthologous to human HNRNPF (heterogeneous nuclear ribonucleoprotein F). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 1974.1), Spleen (RPKM 1482.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Hnrnpf in Genome Data Viewer
    Location:
    4q42
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (152755668..152776867)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (151083262..151104464)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (149957143..149978896)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134486838 Neighboring gene uncharacterized LOC120102375 Neighboring gene FXYD domain-containing ion transport regulator 4 Neighboring gene H2A.Z histone variant 2 like 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Association of the rat heterogeneous nuclear RNA-ribonucleoprotein F with TATA-binding protein. Yoshida T, et al. FEBS Lett, 1999 Aug 27. PMID 10471789
    2. Heterogenous nuclear ribonucleoprotein F modulates angiotensinogen gene expression in rat kidney proximal tubular cells. Wei CC, et al. J Am Soc Nephrol, 2005 Mar. PMID 15659559
    3. Structural basis of G-tract recognition and encaging by hnRNP F quasi-RRMs. Dominguez C, et al. Nat Struct Mol Biol, 2010 Jul. PMID 20526337
    4. Heterogeneous nuclear ribonucleoprotein K modulates angiotensinogen gene expression in kidney cells. Wei CC, et al. J Biol Chem, 2006 Sep 1. PMID 16837467
    5. Interaction between the human nuclear cap-binding protein complex and hnRNP F. Gamberi C, et al. Mol Cell Biol, 1997 May. PMID 9111328, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. hnRNP F protects kidneys against oxidative stress and nephropathy via stimulation of Sirtuin-1 expression and signaling in diabetes.
      Title: Heterogeneous Nuclear Ribonucleoprotein F Stimulates Sirtuin-1 Gene Expression and Attenuates Nephropathy Progression in Diabetic Mice.
    2. These results establish hnRNP H and hnRNP F as being repressors of exon inclusion and suggest that Fox proteins enhance their ability to antagonize ASF/SF2.
      Title: hnRNP H and hnRNP F complex with Fox2 to silence fibroblast growth factor receptor 2 exon IIIc.
    3. hnRNP F binds to rANG-IRE and modulates renal ANG gene expression, implicating that dysregulation of hnRNP F might affect renin-angiotensin system activation and, subsequently, kidney injury in diabetes
      Title: Heterogenous nuclear ribonucleoprotein F modulates angiotensinogen gene expression in rat kidney proximal tubular cells.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC125106

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables TBP-class protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables single-stranded RNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables single-stranded RNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of RNA splicing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of RNA splicing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of RNA splicing ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of catalytic step 2 spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of ribonucleoprotein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in synapse ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    heterogeneous nuclear ribonucleoprotein F
    Names
    hnRNP F
    ribonucleoprotein F

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001037285.1 → NP_001032362.1  heterogeneous nuclear ribonucleoprotein F

      Status: VALIDATED

      Source sequence(s)
      BC103634, CK473366
      UniProtKB/Swiss-Prot
      Q794E4
      UniProtKB/TrEMBL
      A6IL49
      Related
      ENSRNOP00000100838.1, ENSRNOT00000155494.1
      Conserved Domains (4) summary
      pfam08080
      Location:255 → 290
      zf-RNPHF; RNPHF zinc finger
      cd12506
      Location:289 → 363
      RRM3_hnRNPH_CRSF1_like; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein hnRNP H protein family, G-rich sequence factor 1 (GRSF-1) and similar proteins
      cd12729
      Location:10 → 88
      RRM1_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins
      cd12731
      Location:103 → 192
      RRM2_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein hnRNP H, hnRNP H2, hnRNP F and similar proteins

    2. NM_001037286.1 → NP_001032363.1  heterogeneous nuclear ribonucleoprotein F

      Status: VALIDATED

      Source sequence(s)
      BC103634, CK359545
      UniProtKB/Swiss-Prot
      Q794E4
      UniProtKB/TrEMBL
      A6IL49
      Related
      ENSRNOP00000087661.1, ENSRNOT00000108890.2
      Conserved Domains (4) summary
      pfam08080
      Location:255 → 290
      zf-RNPHF; RNPHF zinc finger
      cd12506
      Location:289 → 363
      RRM3_hnRNPH_CRSF1_like; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein hnRNP H protein family, G-rich sequence factor 1 (GRSF-1) and similar proteins
      cd12729
      Location:10 → 88
      RRM1_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins
      cd12731
      Location:103 → 192
      RRM2_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein hnRNP H, hnRNP H2, hnRNP F and similar proteins

    3. NM_001037287.1 → NP_001032364.1  heterogeneous nuclear ribonucleoprotein F

      Status: VALIDATED

      Source sequence(s)
      BC103634, CK366752
      UniProtKB/Swiss-Prot
      Q794E4
      UniProtKB/TrEMBL
      A6IL49
      Related
      ENSRNOP00000068652.1, ENSRNOT00000083843.3
      Conserved Domains (4) summary
      pfam08080
      Location:255 → 290
      zf-RNPHF; RNPHF zinc finger
      cd12506
      Location:289 → 363
      RRM3_hnRNPH_CRSF1_like; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein hnRNP H protein family, G-rich sequence factor 1 (GRSF-1) and similar proteins
      cd12729
      Location:10 → 88
      RRM1_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins
      cd12731
      Location:103 → 192
      RRM2_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein hnRNP H, hnRNP H2, hnRNP F and similar proteins

    4. NM_022397.3 → NP_071792.1  heterogeneous nuclear ribonucleoprotein F

      Status: VALIDATED

      Source sequence(s)
      BC103634, CK473366
      UniProtKB/Swiss-Prot
      Q794E4
      UniProtKB/TrEMBL
      A6IL49
      Conserved Domains (4) summary
      pfam08080
      Location:255 → 290
      zf-RNPHF; RNPHF zinc finger
      cd12506
      Location:289 → 363
      RRM3_hnRNPH_CRSF1_like; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein hnRNP H protein family, G-rich sequence factor 1 (GRSF-1) and similar proteins
      cd12729
      Location:10 → 88
      RRM1_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins
      cd12731
      Location:103 → 192
      RRM2_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein hnRNP H, hnRNP H2, hnRNP F and similar proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      152755668..152776867
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017592875.3 → XP_017448364.1  heterogeneous nuclear ribonucleoprotein F isoform X1

      UniProtKB/Swiss-Prot
      Q794E4
      UniProtKB/TrEMBL
      A6IL49
      Related
      ENSRNOP00000069655.1, ENSRNOT00000091765.3
      Conserved Domains (4) summary
      pfam08080
      Location:255 → 290
      zf-RNPHF; RNPHF zinc finger
      cd12506
      Location:289 → 363
      RRM3_hnRNPH_CRSF1_like; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein hnRNP H protein family, G-rich sequence factor 1 (GRSF-1) and similar proteins
      cd12729
      Location:10 → 88
      RRM1_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins
      cd12731
      Location:103 → 192
      RRM2_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein hnRNP H, hnRNP H2, hnRNP F and similar proteins

    2. XM_063286660.1 → XP_063142730.1  heterogeneous nuclear ribonucleoprotein F isoform X1

      UniProtKB/Swiss-Prot
      Q794E4
      UniProtKB/TrEMBL
      A6IL49

    3. XM_039108313.2 → XP_038964241.1  heterogeneous nuclear ribonucleoprotein F isoform X1

      UniProtKB/Swiss-Prot
      Q794E4
      UniProtKB/TrEMBL
      A6IL49
      Related
      ENSRNOP00000099018.1, ENSRNOT00000141920.1
      Conserved Domains (4) summary
      pfam08080
      Location:255 → 290
      zf-RNPHF; RNPHF zinc finger
      cd12506
      Location:289 → 363
      RRM3_hnRNPH_CRSF1_like; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein hnRNP H protein family, G-rich sequence factor 1 (GRSF-1) and similar proteins
      cd12729
      Location:10 → 88
      RRM1_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins
      cd12731
      Location:103 → 192
      RRM2_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein hnRNP H, hnRNP H2, hnRNP F and similar proteins

    4. XM_039108314.2 → XP_038964242.1  heterogeneous nuclear ribonucleoprotein F isoform X1

      UniProtKB/Swiss-Prot
      Q794E4
      UniProtKB/TrEMBL
      A6IL49
      Conserved Domains (4) summary
      pfam08080
      Location:255 → 290
      zf-RNPHF; RNPHF zinc finger
      cd12506
      Location:289 → 363
      RRM3_hnRNPH_CRSF1_like; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein hnRNP H protein family, G-rich sequence factor 1 (GRSF-1) and similar proteins
      cd12729
      Location:10 → 88
      RRM1_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins
      cd12731
      Location:103 → 192
      RRM2_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein hnRNP H, hnRNP H2, hnRNP F and similar proteins
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q794E4.3 GenPept UniProtKB/Swiss-Prot:Q794E4

    Gene LinkOut

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