Robo1 roundabout guidance receptor 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Robo1provided by RGD
Full Name: roundabout guidance receptor 1provided by RGD
Primary source: RGD:61941
See related: EnsemblRapid:ENSRNOG00000029614 AllianceGenome:RGD:61941
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables axon guidance receptor activity. Involved in several processes, including cellular response to hypoxia; negative regulation of synapse assembly; and nervous system development. Located in axon; dendrite; and neuronal cell body. Biomarker of diabetic retinopathy; lung non-small cell carcinoma; and transient cerebral ischemia. Human ortholog(s) of this gene implicated in autosomal recessive congenital nystagmus; congenital nystagmus; multiple myeloma; panhypopituitarism; and plasmacytoma. Orthologous to human ROBO1 (roundabout guidance receptor 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Adrenal (RPKM 177.6), Brain (RPKM 73.7) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 11p11

Exon count:: 35

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	11	NC_086029.1 (24067869..25108694)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	11	NC_051346.1 (10580863..11621675)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	11	NC_005110.4 (9079291..10146302)

Chromosome 11 - NC_086029.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Expression of Slit and Robo during remodeling of corticospinal tract in cervical spinal cord in middle cerebral artery occlusion rats.
Title: Expression of Slit and Robo during remodeling of corticospinal tract in cervical spinal cord in middle cerebral artery occlusion rats.
This study showed that Robo1 and RhoA were increased in the same surviving neurons in the spinal cord following spinal cord injury.
Title: Slit2/Robo1 promotes synaptogenesis and functional recovery of spinal cord injury.
The alteration of Slit2 and Robo1 expression in the retinas of diabetic rats and patients with proliferative diabetic retinopathy suggests a role for the Slit-Robo signal in the various stages diabetic retinopathy.
Title: The expression of the Slit-Robo signal in the retina of diabetic rats and the vitreous or fibrovascular retinal membranes of patients with proliferative diabetic retinopathy.
data revealed a selective and sustained induction of Slit2 and Robo in astrocytes localized throughout the astroglial scar after ischemic stroke, suggesting that Slit2/Robo signaling participates in glial scar formation and brain remodeling following ischemic injury.
Title: Increased Expression of Slit2 and its Robo Receptors During Astroglial Scar Formation After Transient Focal Cerebral Ischemia in Rats.
Results suggest that Slit2/Robo signaling may be involved in regulating the astroglial reaction via autocrine or paracrine mechanisms in post-ischemic processes.
Title: Increased expression of Slit2 and its receptors Robo1 and Robo4 in reactive astrocytes of the rat hippocampus after transient forebrain ischemia.
Robo1 might not be involved in the inhibitory environment after spinal cord injury
Title: Expression of Slit2 and Robo1 after traumatic lesions of the rat spinal cord.
Data show that at the stage of cerebellofugal axon midline crossing, mRNAs of Robo1 and Robo2 are expressed in the nuclear transitory zone of the cerebellum.
Title: Crucial roles of Robo proteins in midline crossing of cerebellofugal axons and lack of their up-regulation after midline crossing.
Ig domains 1 and 2 of Robo1 are important for Robo-Slit interaction and provide functional data using the Slit-mediated olfactory bulb repulsion assay.
Title: Extracellular Ig domains 1 and 2 of Robo are important for ligand (Slit) binding.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D11Got11 (e-PCR)
- UniSTS:113472

D11Got12 (e-PCR)
- UniSTS:113988

Robo1 (e-PCR), detects polymorphism
- UniSTS:498508

BF386615 (e-PCR)
- UniSTS:243797

BF386668 (e-PCR)
- UniSTS:243807

BF390471 (e-PCR)
- UniSTS:249480

d11rat80 (e-PCR)
- UniSTS:120795

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables LRR domain binding	ISO Inferred from Sequence Orthology more info
enables axon guidance receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables axon guidance receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables axon guidance receptor activity	IEA Inferred from Electronic Annotation more info
enables axon guidance receptor activity	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in Roundabout signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in Roundabout signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in Roundabout signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in aorta development	ISO Inferred from Sequence Orthology more info
involved_in aortic valve morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in axon guidance	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within axon guidance	ISO Inferred from Sequence Orthology more info
involved_in axon midline choice point recognition	IEA Inferred from Electronic Annotation more info
involved_in axon midline choice point recognition	IEP Inferred from Expression Pattern more info	PubMed
involved_in axon midline choice point recognition	ISO Inferred from Sequence Orthology more info
involved_in cell migration involved in sprouting angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in cellular response to hypoxia	IEP Inferred from Expression Pattern more info	PubMed
involved_in chemorepulsion involved in postnatal olfactory bulb interneuron migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within coronary vasculature development	ISO Inferred from Sequence Orthology more info
involved_in endocardial cushion formation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within heart development	ISO Inferred from Sequence Orthology more info
involved_in heart induction	ISO Inferred from Sequence Orthology more info
involved_in homophilic cell adhesion via plasma membrane adhesion molecules	IBA Inferred from Biological aspect of Ancestor more info
involved_in homophilic cell adhesion via plasma membrane adhesion molecules	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within kidney development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within mammary duct terminal end bud growth	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell migration	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of chemokine-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of mammary gland epithelial cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of negative chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of synapse assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron projection extension	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in olfactory bulb interneuron development	ISO Inferred from Sequence Orthology more info
involved_in oligodendrocyte development	IEP Inferred from Expression Pattern more info	PubMed
involved_in outflow tract septum morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of MAP kinase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of Notch signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of Rho protein signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of Rho protein signal transduction	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of axonogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cysteine-type endopeptidase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of vascular endothelial growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of vascular endothelial growth factor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in pulmonary valve morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in regulation of dendrite morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in spinal cord development	IEP Inferred from Expression Pattern more info	PubMed
involved_in synapse organization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within ventricular septum development	ISO Inferred from Sequence Orthology more info
involved_in ventricular septum morphogenesis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in axolemma	ISO Inferred from Sequence Orthology more info
is_active_in axon	IBA Inferred from Biological aspect of Ancestor more info
located_in axon	IDA Inferred from Direct Assay more info	PubMed
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum-Golgi intermediate compartment membrane	IEA Inferred from Electronic Annotation more info
is_active_in neuronal cell body	IBA Inferred from Biological aspect of Ancestor more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: roundabout homolog 1

Names: roundabout, axon guidance receptor, homolog 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001415011.1 → NP_001401940.1 roundabout homolog 1 isoform 2 precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000011

UniProtKB/TrEMBL

A0A8I5ZZ95, A0A8I6ASP5

Related

ENSRNOP00000096544.2, ENSRNOT00000104951.2
NM_022188.3 → NP_071524.2 roundabout homolog 1 isoform 1 precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000011

UniProtKB/Swiss-Prot

O55005

UniProtKB/TrEMBL

F1LQI2

Related

ENSRNOP00000044134.7, ENSRNOT00000042384.7

Conserved Domains (7) summary

cd00063
Location:561 → 647

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00041
Location:778 → 864

fn3; Fibronectin type III domain

cd05724
Location:173 → 258

IgI_2_Robo; Second immunoglobulin (Ig)-like domain in Robo (roundabout) receptors; member of the I-set of Ig superfamily (IgSF) domains

cd05725
Location:265 → 347

IgI_3_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors; member of the I-set of Ig superfamily (IgSF) domains

cd05726
Location:352 → 449

IgI_4_Robo; Fourth immunoglobulin (Ig)-like domain in Robo (roundabout) receptors; member of the I-set of Ig superfamily (IgSF) domains

cd07693
Location:68 → 166

IgC_1_Robo; First immunoglobulin (Ig)-like constant domain in Robo (roundabout) receptors, and similar domains

cd20952
Location:456 → 542

IgI_5_Robo; Fifth Ig-like domain of Roundabout (Robo) homolog 1/2, and similar domains; a member of the I-set of IgSF domains

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086029.1 Reference GRCr8

Range

24067869..25108694

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063270751.1 → XP_063126821.1 roundabout homolog 1 isoform X11

UniProtKB/Swiss-Prot

O55005
XM_063270753.1 → XP_063126823.1 roundabout homolog 1 isoform X13

UniProtKB/Swiss-Prot

O55005
XM_063270742.1 → XP_063126812.1 roundabout homolog 1 isoform X3

UniProtKB/Swiss-Prot

O55005
XM_063270752.1 → XP_063126822.1 roundabout homolog 1 isoform X12

UniProtKB/TrEMBL

A0A8I5ZX35
XM_063270749.1 → XP_063126819.1 roundabout homolog 1 isoform X9

UniProtKB/Swiss-Prot

O55005
XM_063270743.1 → XP_063126813.1 roundabout homolog 1 isoform X4

UniProtKB/TrEMBL

A0A8I5ZX35
XM_063270740.1 → XP_063126810.1 roundabout homolog 1 isoform X1

UniProtKB/Swiss-Prot

O55005
XM_063270754.1 → XP_063126824.1 roundabout homolog 1 isoform X14

UniProtKB/TrEMBL

A0A8I5ZX35
XM_063270745.1 → XP_063126815.1 roundabout homolog 1 isoform X6

UniProtKB/TrEMBL

A0A8I6ASP5
XM_063270750.1 → XP_063126820.1 roundabout homolog 1 isoform X10

UniProtKB/Swiss-Prot

O55005
XM_063270744.1 → XP_063126814.1 roundabout homolog 1 isoform X5

UniProtKB/TrEMBL

A0A8I5ZX35

Related

ENSRNOP00000069709.2, ENSRNOT00000087080.3
XM_063270741.1 → XP_063126811.1 roundabout homolog 1 isoform X2

UniProtKB/Swiss-Prot

O55005
XM_063270746.1 → XP_063126816.1 roundabout homolog 1 isoform X7

UniProtKB/TrEMBL

A0A8I6ASP5

Related

ENSRNOP00000111481.1, ENSRNOT00000130873.1
XM_063270756.1 → XP_063126826.1 roundabout homolog 1 isoform X16

UniProtKB/TrEMBL

A0A8I5ZX35
XM_063270757.1 → XP_063126827.1 roundabout homolog 1 isoform X17

UniProtKB/TrEMBL

A0A8I5ZX35
XM_063270748.1 → XP_063126818.1 roundabout homolog 1 isoform X8

UniProtKB/TrEMBL

A0A8I6ASP5
XM_063270755.1 → XP_063126825.1 roundabout homolog 1 isoform X15

UniProtKB/TrEMBL

A0A8I6ASP5