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    Cnot2 CCR4-NOT transcription complex, subunit 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 299805, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Cnot2provided by RGD
    Official Full Name
    CCR4-NOT transcription complex, subunit 2provided by RGD
    Primary source
    RGD:1311672
    See related
    EnsemblRapid:ENSRNOG00000004909 AllianceGenome:RGD:1311672
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable transcription corepressor binding activity. Predicted to contribute to poly(A)-specific ribonuclease activity. Predicted to be involved in several processes, including negative regulation of intracellular estrogen receptor signaling pathway; positive regulation of cytoplasmic mRNA processing body assembly; and regulation of RNA metabolic process. Predicted to be located in cytosol; nucleoplasm; and plasma membrane. Predicted to be part of CCR4-NOT core complex. Predicted to be active in P-body. Orthologous to human CNOT2 (CCR4-NOT transcription complex subunit 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 397.7), Kidney (RPKM 240.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Cnot2 in Genome Data Viewer
    Location:
    7q22
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (54016447..54117511, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (52130445..52222338, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (59526105..59617307, complement)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene protein tyrosine phosphatase, receptor type, B Neighboring gene potassium calcium-activated channel subfamily M regulatory beta subunit 4 Neighboring gene protein disulfide isomerase family A, member 4, pseudogene 1 Neighboring gene uncharacterized LOC120093596

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. CNOT2 depletion disrupts and inhibits the CCR4-NOT deadenylase complex and induces apoptotic cell death. Ito K, et al. Genes Cells, 2011 Apr. PMID 21299754
    2. Repression of promoter activity by CNOT2, a subunit of the transcription regulatory Ccr4-not complex. Zwartjes CG, et al. J Biol Chem, 2004 Mar 19. PMID 14707134
    3. Involvement of the SMRT/NCoR-HDAC3 complex in transcriptional repression by the CNOT2 subunit of the human Ccr4-Not complex. Jayne S, et al. Biochem J, 2006 Sep 15. PMID 16712523, Free PMC Article
    4. Cnot1, Cnot2, and Cnot3 maintain mouse and human ESC identity and inhibit extraembryonic differentiation. Zheng X, et al. Stem Cells, 2012 May. PMID 22367759, Free PMC Article
    5. RNA decay machines: deadenylation by the Ccr4-not and Pan2-Pan3 complexes. Wahle E, et al. Biochim Biophys Acta, 2013 Jun-Jul. PMID 23337855

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    contributes_to poly(A)-specific ribonuclease activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transcription corepressor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in negative regulation of intracellular estrogen receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in nuclear-transcribed mRNA poly(A) tail shortening IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of cytoplasmic mRNA processing body assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of stem cell population maintenance IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of stem cell population maintenance ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in trophectodermal cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of CCR4-NOT complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of CCR4-NOT core complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in P-body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    CCR4-NOT transcription complex subunit 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001399553.1 → NP_001386482.1  CCR4-NOT transcription complex subunit 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/TrEMBL
      A0A8I5Y9U2, A0A8I6AJD1

    2. NM_001399554.1 → NP_001386483.1  CCR4-NOT transcription complex subunit 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/TrEMBL
      A0A8I6AJD1
      Related
      ENSRNOP00000077944.2, ENSRNOT00000114739.2

    3. NM_001399555.1 → NP_001386484.1  CCR4-NOT transcription complex subunit 2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/TrEMBL
      A0A0G2KB82, A0A8I6AJD1
      Related
      ENSRNOP00000078367.2, ENSRNOT00000100132.2

    4. NM_001399556.1 → NP_001386485.1  CCR4-NOT transcription complex subunit 2 isoform 4

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/TrEMBL
      A6IGN5, A6IGP1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      54016447..54117511 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039078732.2 → XP_038934660.1  CCR4-NOT transcription complex subunit 2 isoform X8

      UniProtKB/TrEMBL
      A6IGN0
      Conserved Domains (1) summary
      pfam04153
      Location:228 → 351
      NOT2_3_5; NOT2 / NOT3 / NOT5 family

    2. XM_006241369.4 → XP_006241431.1  CCR4-NOT transcription complex subunit 2 isoform X3

      See identical proteins and their annotated locations for XP_006241431.1

      UniProtKB/TrEMBL
      A0A8I6AJD1
      Related
      ENSRNOP00000084380.2, ENSRNOT00000104908.2
      Conserved Domains (1) summary
      pfam04153
      Location:365 → 488
      NOT2_3_5; NOT2 / NOT3 / NOT5 family

    3. XM_039078728.2 → XP_038934656.1  CCR4-NOT transcription complex subunit 2 isoform X6

      UniProtKB/TrEMBL
      A6IGN1
      Conserved Domains (1) summary
      pfam04153
      Location:269 → 392
      NOT2_3_5; NOT2 / NOT3 / NOT5 family

    4. XM_039078720.2 → XP_038934648.1  CCR4-NOT transcription complex subunit 2 isoform X2

      UniProtKB/TrEMBL
      A0A0G2KB82, A0A8I6AJD1
      Conserved Domains (1) summary
      pfam04153
      Location:387 → 510
      NOT2_3_5; NOT2 / NOT3 / NOT5 family

    5. XM_017594741.3 → XP_017450230.1  CCR4-NOT transcription complex subunit 2 isoform X4

      UniProtKB/TrEMBL
      A0A8I5ZXR1, A6IGN2
      Conserved Domains (1) summary
      pfam04153
      Location:355 → 478
      NOT2_3_5; NOT2 / NOT3 / NOT5 family

    6. XM_039078730.2 → XP_038934658.1  CCR4-NOT transcription complex subunit 2 isoform X7

      UniProtKB/TrEMBL
      A0A8I5ZKS1, A6IGN1
      Conserved Domains (1) summary
      pfam04153
      Location:259 → 382
      NOT2_3_5; NOT2 / NOT3 / NOT5 family

    7. XM_039078717.2 → XP_038934645.1  CCR4-NOT transcription complex subunit 2 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AJD1
      Conserved Domains (1) summary
      pfam04153
      Location:396 → 519
      NOT2_3_5; NOT2 / NOT3 / NOT5 family

    8. XM_063263224.1 → XP_063119294.1  CCR4-NOT transcription complex subunit 2 isoform X5

      UniProtKB/TrEMBL
      A6IGN2, A6IGP0
      Related
      ENSRNOP00000061277.1, ENSRNOT00000066396.4

    9. XM_039078735.2 → XP_038934663.1  CCR4-NOT transcription complex subunit 2 isoform X11

      UniProtKB/TrEMBL
      A6IGP2
      Conserved Domains (1) summary
      pfam04153
      Location:136 → 259
      NOT2_3_5; NOT2 / NOT3 / NOT5 family

    10. XM_063263225.1 → XP_063119295.1  CCR4-NOT transcription complex subunit 2 isoform X9

    11. XM_063263226.1 → XP_063119296.1  CCR4-NOT transcription complex subunit 2 isoform X10

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001011988.2: Suppressed sequence

      Description
      NM_001011988.2: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

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