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    Hadh hydroxyacyl-CoA dehydrogenase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 113965, updated on 4-Jan-2025

    Summary

    Official Symbol
    Hadhprovided by RGD
    Official Full Name
    hydroxyacyl-CoA dehydrogenaseprovided by RGD
    Primary source
    RGD:69321
    See related
    EnsemblRapid:ENSRNOG00000010697 AllianceGenome:RGD:69321
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Hadhsc
    Summary
    Enables 3-hydroxyacyl-CoA dehydrogenase activity. Involved in several processes, including fatty acid beta-oxidation; negative regulation of insulin secretion; and response to insulin. Predicted to be located in cytoplasm and nucleoplasm. Predicted to be active in mitochondrion. Biomarker of myocardial infarction and obesity. Human ortholog(s) of this gene implicated in familial hyperinsulinemic hypoglycemia 4. Orthologous to human HADH (hydroxyacyl-CoA dehydrogenase). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in Heart (RPKM 1783.9), Liver (RPKM 1530.5) and 8 other tissues See more
    Orthologs
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    Genomic context

    See Hadh in Genome Data Viewer
    Location:
    2q43
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (222462049..222504446, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (219787935..219830335, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (236353445..236395067, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene lymphoid enhancer binding factor 1 Neighboring gene lymphoid enhancer binding factor 1 like Neighboring gene uncharacterized LOC120100943 Neighboring gene cytochrome P450, family 2, subfamily u, polypeptide 1 Neighboring gene uncharacterized LOC134485686 Neighboring gene aminoacyl tRNA synthetase complex-interacting multifunctional protein 1, pseudogene 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 3-hydroxyacyl-CoA dehydrogenase activity  
    enables 3-hydroxyacyl-CoA dehydrogenase activity PubMed 
    enables 3-hydroxyacyl-CoA dehydrogenase activity  
    enables 3-hydroxyacyl-CoA dehydrogenase activity  
    enables NAD+ binding  
    enables NAD+ binding  
    enables identical protein binding  
    enables identical protein binding  
    Process Evidence Code Pubs
    involved_in cell differentiation  
    involved_in fatty acid beta-oxidation  
    involved_in fatty acid beta-oxidation  
    involved_in fatty acid beta-oxidation PubMed 
    involved_in fatty acid beta-oxidation  
    involved_in fatty acid beta-oxidation  
    involved_in negative regulation of insulin secretion PubMed 
    involved_in positive regulation of cold-induced thermogenesis  
    involved_in positive regulation of cold-induced thermogenesis PubMed 
    involved_in regulation of insulin secretion  
    involved_in regulation of insulin secretion  
    involved_in response to activity PubMed 
    involved_in response to hormone PubMed 
    involved_in response to insulin PubMed 
    involved_in response to xenobiotic stimulus PubMed 
    involved_in spermatogenesis  
    Component Evidence Code Pubs
    located_in cytoplasm  
    located_in mitochondrial matrix  
    is_active_in mitochondrion  
    located_in mitochondrion  
    located_in nucleoplasm  
    located_in nucleoplasm  

    General protein information

    Preferred Names
    hydroxyacyl-coenzyme A dehydrogenase, mitochondrial
    Names
    HCDH
    L-3-hydroxyacyl-Coenzyme A dehydrogenase, short chain
    hydroxylacyl-Coenzyme A dehydrogenase, short chain
    medium and short-chain L-3-hydroxyacyl-coenzyme A dehydrogenase
    short-chain 3-hydroxyacyl-CoA dehydrogenase
    NP_476534.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_057186.2NP_476534.1  hydroxyacyl-coenzyme A dehydrogenase, mitochondrial precursor

      Status: PROVISIONAL

      Source sequence(s)
      AF095449
      UniProtKB/Swiss-Prot
      Q9WVK7
      UniProtKB/TrEMBL
      A6HVS6
      Related
      ENSRNOP00000014658.1, ENSRNOT00000014658.4
      Conserved Domains (1) summary
      COG1250
      Location:27313
      FadB; 3-hydroxyacyl-CoA dehydrogenase [Lipid transport and metabolism]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      222462049..222504446 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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