U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Fh fumarate hydratase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 24368, updated on 27-Dec-2024

    Summary

    Official Symbol
    Fhprovided by RGD
    Official Full Name
    fumarate hydrataseprovided by RGD
    Primary source
    RGD:2614
    See related
    EnsemblRapid:ENSRNOG00000003653 AllianceGenome:RGD:2614
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Fh1
    Summary
    Enables fumarate hydratase activity. Predicted to be involved in several processes, including dicarboxylic acid metabolic process; positive regulation of metabolic process; and tricarboxylic acid cycle. Predicted to act upstream of or within homeostasis of number of cells within a tissue. Predicted to be located in cytosol; nucleus; and site of double-strand break. Predicted to be active in mitochondrial matrix. Human ortholog(s) of this gene implicated in fumarase deficiency and lung non-small cell carcinoma. Orthologous to human FH (fumarate hydratase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 1154.8), Muscle (RPKM 921.8) and 9 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Location:
    13q24
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (90056565..90082450, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (87524331..87550215, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (93651486..93677371, complement)

    Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene mortality factor 4 like 1, pseudogene 4 Neighboring gene uncharacterized LOC120096320 Neighboring gene uncharacterized LOC134481597 Neighboring gene kynurenine 3-monooxygenase Neighboring gene small ribosomal subunit protein eS1-like Neighboring gene opsin 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Clone Names

    • MGC105468

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables fumarate hydratase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables fumarate hydratase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables fumarate hydratase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables fumarate hydratase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables histone binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in DNA damage response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in DNA damage response ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in arginine metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in fumarate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in fumarate metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in fumarate metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in fumarate metabolic process TAS
    Traceable Author Statement
    more info
    PubMed 
    acts_upstream_of_or_within homeostasis of number of cells within a tissue ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in malate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in malate metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cold-induced thermogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cold-induced thermogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in positive regulation of double-strand break repair via nonhomologous end joining ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of double-strand break repair via nonhomologous end joining ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of arginine metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of arginine metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in tricarboxylic acid cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in tricarboxylic acid cycle IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in tricarboxylic acid cycle ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of urea cycle ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of urea cycle ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in mitochondrial matrix ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in site of double-strand break ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    fumarate hydratase, mitochondrial
    Names
    fumarase
    fumarate hydratase 1
    NP_058701.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_017005.2NP_058701.2  fumarate hydratase, mitochondrial precursor

      See identical proteins and their annotated locations for NP_058701.2

      Status: PROVISIONAL

      Source sequence(s)
      BC087598
      UniProtKB/Swiss-Prot
      P14408, Q5M964
      Related
      ENSRNOP00000004917.4, ENSRNOT00000004917.7
      Conserved Domains (1) summary
      PRK00485
      Location:46507
      fumC; fumarate hydratase; Reviewed

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086031.1 Reference GRCr8

      Range
      90056565..90082450 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)