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    Pde7a phosphodiesterase 7A [ Rattus norvegicus (Norway rat) ]

    Gene ID: 81744, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Pde7aprovided by RGD
    Official Full Name
    phosphodiesterase 7Aprovided by RGD
    Primary source
    RGD:68391
    See related
    EnsemblRapid:ENSRNOG00000013048 AllianceGenome:RGD:68391
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    PDE7-1
    Summary
    Enables cyclic-nucleotide phosphodiesterase activity. Predicted to be involved in cAMP-mediated signaling. Orthologous to human PDE7A (phosphodiesterase 7A). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 87.0), Spleen (RPKM 71.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Pde7a in Genome Data Viewer
    Location:
    2q24
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (103631655..103723057, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (101714767..101806853, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (104042124..104134101, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene armadillo repeat containing 1 Neighboring gene mitochondrial fission regulator 1 Neighboring gene RAB5C, member RAS oncogene family, pseudogene 1 Neighboring gene uncharacterized LOC103691515

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Phosphodiesterase7 Inhibition Activates Adult Neurogenesis in Hippocampus and Subventricular Zone In Vitro and In Vivo. Morales-Garcia JA, et al. Stem Cells, 2017 Feb. PMID 27538853
    2. Pharmacological profile of a novel phosphodiesterase 7A and -4 dual inhibitor, YM-393059, on acute and chronic inflammation models. Yamamoto S, et al. Eur J Pharmacol, 2006 Nov 21. PMID 17010967
    3. Differential distribution of cAMP-specific phosphodiesterase 7A mRNA in rat brain and peripheral organs. Miró X, et al. Synapse, 2001 Jun 1. PMID 11304758
    4. Differential distribution of rat PDE-7 mRNA in embryonic and adult rat brain. Hoffmann R, et al. Cell Biochem Biophys, 1998. PMID 9515162
    5. Identification and tissue-specific expression of PDE7 phosphodiesterase splice variants. Bloom TJ, et al. Proc Natl Acad Sci U S A, 1996 Nov 26. PMID 8943082, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. PDE7 inhibition controls stem cell expansion in the subgranular zone of the dentate gyrus of the hippocampus (SGZ) and the subventricular zone (SVZ) in the adult rat brain.
      Title: Phosphodiesterase7 Inhibition Activates Adult Neurogenesis in Hippocampus and Subventricular Zone In Vitro and In Vivo.
    2. results are consistent with PDE7A being involved in the regulation of cAMP signaling in many brain functions.
      Title: Differential distribution of cAMP-specific phosphodiesterase 7A mRNA in rat brain and peripheral organs.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 3',5'-cyclic-AMP phosphodiesterase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 3',5'-cyclic-AMP phosphodiesterase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables 3',5'-cyclic-AMP phosphodiesterase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables 3',5'-cyclic-GMP phosphodiesterase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 3',5'-cyclic-nucleotide phosphodiesterase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cyclic-nucleotide phosphodiesterase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cAMP catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cAMP-mediated signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cAMP-mediated signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    high affinity 3',5'-cyclic-AMP phosphodiesterase 7A
    Names
    cAMP-specific phosphodiesterase 7A
    high affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A
    rolipram-insensitive phosphodiesterase type 7
    NP_112342.1
    XP_006232250.1
    XP_008759102.1
    XP_038959155.1
    XP_038959156.1
    XP_063138701.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031080.1 → NP_112342.1  high affinity 3',5'-cyclic-AMP phosphodiesterase 7A

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/Swiss-Prot
      O08593
      UniProtKB/TrEMBL
      F1LM88
      Related
      ENSRNOP00000060777.1, ENSRNOT00000067725.4
      Conserved Domains (1) summary
      pfam00233
      Location:211 → 431
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      103631655..103723057 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006232188.5 → XP_006232250.1  high affinity 3',5'-cyclic-AMP phosphodiesterase 7A isoform X1

      UniProtKB/Swiss-Prot
      O08593
      UniProtKB/TrEMBL
      A0A8I6A6L3
      Related
      ENSRNOP00000086827.1, ENSRNOT00000108651.2
      Conserved Domains (1) summary
      pfam00233
      Location:185 → 405
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

    2. XM_008760880.4 → XP_008759102.1  high affinity 3',5'-cyclic-AMP phosphodiesterase 7A isoform X2

      UniProtKB/Swiss-Prot
      O08593
      Related
      ENSRNOP00000111863.1, ENSRNOT00000143772.1
      Conserved Domains (1) summary
      pfam00233
      Location:155 → 375
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

    3. XM_039103227.2 → XP_038959155.1  high affinity 3',5'-cyclic-AMP phosphodiesterase 7A isoform X3

      Conserved Domains (1) summary
      pfam00233
      Location:65 → 285
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

    4. XM_063282631.1 → XP_063138701.1  high affinity 3',5'-cyclic-AMP phosphodiesterase 7A isoform X5

    5. XM_039103228.2 → XP_038959156.1  high affinity 3',5'-cyclic-AMP phosphodiesterase 7A isoform X4

      Conserved Domains (1) summary
      cl21469
      Location:211 → 309
      HDc; Metal dependent phosphohydrolases with conserved 'HD' motif

    RNA

    1. XR_005500379.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O08593.1 GenPept UniProtKB/Swiss-Prot:O08593

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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