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    Selenop selenoprotein P [ Rattus norvegicus (Norway rat) ]

    Gene ID: 29360, updated on 9-Dec-2024

    Summary

    Official Symbol
    Selenopprovided by RGD
    Official Full Name
    selenoprotein Pprovided by RGD
    Primary source
    RGD:3660
    See related
    EnsemblRapid:ENSRNOG00000053086 AllianceGenome:RGD:3660
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Sepp1
    Summary
    This gene encodes a selenoprotein that is predominantly expressed in the liver and secreted into the plasma. This selenoprotein is unique in that it contains multiple selenocysteine (Sec) residues per polypeptide (10 in rat), and accounts for most of the selenium in plasma. It has been implicated as an extracellular antioxidant, and in the transport of selenium to extra-hepatic tissues via apolipoprotein E receptor-2 (apoER2). Mice lacking this gene exhibit neurological dysfunction, suggesting its importance in normal brain function. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. The mRNA for this selenoprotein contains two SECIS elements. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Feb 2017]
    Expression
    Biased expression in Liver (RPKM 24050.5), Kidney (RPKM 13784.7) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Selenop in Genome Data Viewer
    Location:
    2q16
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (54225736..54236022)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (52498123..52508409)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (53105912..53116198)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene coenzyme Q-binding protein COQ10 homolog B, mitochondrial-like Neighboring gene uncharacterized LOC102548571 Neighboring gene uncharacterized LOC103691472 Neighboring gene coiled-coil domain containing 152 Neighboring gene growth hormone receptor

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables selenium binding  
    enables selenium binding  
    enables selenium binding  
    Process Evidence Code Pubs
    involved_in brain development  
    acts_upstream_of_or_within brain development  
    involved_in locomotory behavior  
    acts_upstream_of_or_within locomotory behavior  
    involved_in post-embryonic development  
    acts_upstream_of_or_within post-embryonic development  
    involved_in regulation of growth  
    acts_upstream_of_or_within regulation of growth  
    involved_in response to selenium ion PubMed 
    involved_in selenium compound metabolic process  
    involved_in selenium compound metabolic process  
    acts_upstream_of_or_within selenium compound metabolic process  
    involved_in sexual reproduction  
    acts_upstream_of_or_within sexual reproduction  
    Component Evidence Code Pubs
    is_active_in extracellular region  
    located_in extracellular space  
    located_in extracellular space  

    General protein information

    Preferred Names
    selenoprotein P
    Names
    seP
    selenoprotein P, plasma, 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001083911.1NP_001077380.1  selenoprotein P precursor

      See identical proteins and their annotated locations for NP_001077380.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2, also known as Sepp1b) uses an alternate 5' non-coding exon, hence has a different 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein containing 10 selenocysteine residues.
      Source sequence(s)
      BC072539, BF389559, CB699091, CB745388
      UniProtKB/Swiss-Prot
      P25236
      Related
      ENSRNOP00000069020.2, ENSRNOT00000086590.3
      Conserved Domains (2) summary
      pfam04592
      Location:23243
      SelP_N; Selenoprotein P, N terminal region
      pfam04593
      Location:254372
      SelP_C; Selenoprotein P, C terminal region
    2. NM_019192.2NP_062065.2  selenoprotein P precursor

      See identical proteins and their annotated locations for NP_062065.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1, also known as Sepp1a) represents the predominant transcript. Variants 1 and 2 encode the same protein containing 10 selenocysteine residues.
      Source sequence(s)
      BC072539, BF389559, DN933732
      UniProtKB/Swiss-Prot
      P25236
      Conserved Domains (2) summary
      pfam04592
      Location:23243
      SelP_N; Selenoprotein P, N terminal region
      pfam04593
      Location:254372
      SelP_C; Selenoprotein P, C terminal region

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      54225736..54236022
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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