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    Sord sorbitol dehydrogenase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 24788, updated on 4-Jan-2025

    Summary

    Official Symbol
    Sordprovided by RGD
    Official Full Name
    sorbitol dehydrogenaseprovided by RGD
    Primary source
    RGD:3734
    See related
    EnsemblRapid:ENSRNOG00000017291 AllianceGenome:RGD:3734
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    SDH; XDH
    Summary
    Enables identical protein binding activity and zinc ion binding activity. Involved in several processes, including response to cadmium ion; response to copper ion; and response to hormone. Predicted to be located in several cellular components, including extracellular exosome; mitochondrion; and motile cilium. Predicted to be active in cytosol. Used to study diabetic neuropathy. Human ortholog(s) of this gene implicated in autosomal recessive distal hereditary motor neuronopathy 8. Orthologous to human SORD (sorbitol dehydrogenase). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in Liver (RPKM 2300.8), Kidney (RPKM 1771.3) and 6 other tissues See more
    Orthologs
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    Genomic context

    See Sord in Genome Data Viewer
    Location:
    3q35
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (129638282..129669727)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (109184697..109216133)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (114176127..114207368)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene tripartite motif-containing 69 Neighboring gene telomere repeat binding bouquet formation protein 2 Neighboring gene uncharacterized LOC134486430 Neighboring gene thymidine kinase 1, pseudogene 2 Neighboring gene dual oxidase 2 Neighboring gene dual oxidase maturation factor 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables D-sorbitol dehydrogenase (acceptor) activity  
    enables D-sorbitol dehydrogenase (acceptor) activity  
    enables D-xylulose reductase activity  
    enables D-xylulose reductase activity  
    enables L-iditol 2-dehydrogenase (NAD+) activity  
    enables L-iditol 2-dehydrogenase (NAD+) activity  
    enables L-iditol 2-dehydrogenase (NAD+) activity  
    enables NAD binding  
    enables NAD binding  
    enables identical protein binding PubMed 
    enables identical protein binding  
    enables identical protein binding  
    enables zinc ion binding PubMed 
    enables zinc ion binding  
    enables zinc ion binding  
    Process Evidence Code Pubs
    involved_in D-glucuronate catabolic process to D-xylulose 5-phosphate  
    involved_in D-glucuronate catabolic process to D-xylulose 5-phosphate  
    involved_in flagellated sperm motility  
    involved_in flagellated sperm motility  
    involved_in flagellated sperm motility  
    involved_in fructose biosynthetic process  
    involved_in fructose biosynthetic process  
    involved_in response to cadmium ion PubMed 
    involved_in response to copper ion PubMed 
    involved_in response to hormone PubMed 
    involved_in response to nutrient levels PubMed 
    involved_in response to xenobiotic stimulus PubMed 
    involved_in sorbitol catabolic process  
    involved_in sorbitol catabolic process  
    involved_in sorbitol catabolic process  
    acts_upstream_of_or_within sorbitol metabolic process  
    involved_in xylitol catabolic process  
    involved_in xylitol catabolic process  
    involved_in xylitol metabolic process  
    Component Evidence Code Pubs
    located_in cytosol  
    is_active_in cytosol  
    located_in extracellular exosome  
    located_in extracellular exosome  
    located_in membrane  
    located_in membrane  
    located_in mitochondrial membrane  
    located_in mitochondrion  
    located_in mitochondrion  
    located_in motile cilium  
    located_in motile cilium  
    located_in motile cilium  

    General protein information

    Preferred Names
    sorbitol dehydrogenase
    Names
    L-iditol 2-dehydrogenase
    polyol dehydrogenase
    xylitol dehydrogenase
    NP_058748.2
    XP_017446963.1
    XP_063139178.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_017052.2NP_058748.2  sorbitol dehydrogenase

      See identical proteins and their annotated locations for NP_058748.2

      Status: PROVISIONAL

      Source sequence(s)
      BC088398
      UniProtKB/Swiss-Prot
      A2VCV9, P27867, Q4FZY4, Q5I0F3
      UniProtKB/TrEMBL
      A0A8L2QD42, A6HPS1
      Related
      ENSRNOP00000084990.2, ENSRNOT00000117801.2
      Conserved Domains (1) summary
      cd05285
      Location:11350
      sorbitol_DH; Sorbitol dehydrogenase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      129638282..129669727
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017591474.3XP_017446963.1  sorbitol dehydrogenase isoform X1

      UniProtKB/TrEMBL
      A0A8I6A2A0, A0A8L2QD42
    2. XM_063283108.1XP_063139178.1  sorbitol dehydrogenase isoform X2

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