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    Snai1 snail family transcriptional repressor 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 116490, updated on 4-Jan-2025

    Summary

    Official Symbol
    Snai1provided by RGD
    Official Full Name
    snail family transcriptional repressor 1provided by RGD
    Primary source
    RGD:620758
    See related
    AllianceGenome:RGD:620758
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Sna
    Summary
    Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific; E-box binding activity; and kinase binding activity. Predicted to be involved in several processes, including cell surface receptor signaling pathway; negative regulation of intracellular signal transduction; and regulation of DNA-templated transcription. Predicted to act upstream of or within several processes, including hair follicle morphogenesis; negative regulation of cell differentiation involved in embryonic placenta development; and trophoblast giant cell differentiation. Predicted to be located in cytosol; nuclear lumen; and pericentric heterochromatin. Biomarker of rheumatic heart disease. Orthologous to human SNAI1 (snail family transcriptional repressor 1). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in Lung (RPKM 29.2), Kidney (RPKM 12.6) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Snai1 in Genome Data Viewer
    Location:
    3q42
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (176667476..176671965)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (156248479..156252969)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (164274710..164279199)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene spermatogenesis associated 2 Neighboring gene ring finger protein 114 Neighboring gene uncharacterized LOC134486210 Neighboring gene uncharacterized LOC134486209 Neighboring gene uncharacterized LOC120101789

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    General gene information

    Gene Ontology Provided by RGD

    Items 1 - 25 of 29
    Process Evidence Code Pubs
    involved_in Notch signaling pathway  
    involved_in canonical Wnt signaling pathway  
    acts_upstream_of_or_within cartilage morphogenesis  
    acts_upstream_of_or_within epithelial cell migration  
    involved_in epithelial to mesenchymal transition  
    involved_in epithelial to mesenchymal transition PubMed 
    involved_in epithelial to mesenchymal transition involved in endocardial cushion formation  
    acts_upstream_of_or_within hair follicle morphogenesis  
    involved_in heterochromatin organization  
    acts_upstream_of_or_within left/right pattern formation  
    acts_upstream_of_or_within mesoderm development  
    involved_in mesoderm formation  
    involved_in negative regulation of DNA damage response, signal transduction by p53 class mediator  
    involved_in negative regulation of DNA-templated transcription  
    involved_in negative regulation of cell cycle PubMed 
    acts_upstream_of_or_within negative regulation of cell differentiation involved in embryonic placenta development  
    involved_in negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage  
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II  
    involved_in negative regulation of transcription by RNA polymerase II  
    involved_in negative regulation of vitamin D biosynthetic process  
    involved_in osteoblast differentiation  
    involved_in positive regulation of DNA-templated transcription  
    involved_in positive regulation of cell migration  
    involved_in positive regulation of epithelial to mesenchymal transition  
    involved_in regulation of DNA-templated transcription  
    involved_in regulation of bicellular tight junction assembly  
    acts_upstream_of_or_within regulation of transcription by RNA polymerase II  
    acts_upstream_of_or_within roof of mouth development  
    acts_upstream_of_or_within trophoblast giant cell differentiation  
    Items 1 - 25 of 29
    Component Evidence Code Pubs
    located_in cytoplasm  
    located_in cytosol  
    located_in fibrillar center  
    located_in intracellular membrane-bounded organelle  
    located_in nucleoplasm  
    located_in nucleus  
    located_in pericentric heterochromatin  

    General protein information

    Preferred Names
    zinc finger protein SNAI1
    Names
    snail family zinc finger 1
    snail homolog 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053805.1NP_446257.1  zinc finger protein SNAI1

      See identical proteins and their annotated locations for NP_446257.1

      Status: PROVISIONAL

      Source sequence(s)
      BC079210
      UniProtKB/TrEMBL
      E9PU82, Q6AY35
      Conserved Domains (4) summary
      COG5048
      Location:177253
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:182202
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:208230
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:195218
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      176667476..176671965
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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