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    Tspan18 tetraspanin 18 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 311210, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tspan18provided by RGD
    Official Full Name
    tetraspanin 18provided by RGD
    Primary source
    RGD:1560411
    See related
    EnsemblRapid:ENSRNOG00000008758 AllianceGenome:RGD:1560411
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1560411
    Summary
    Predicted to be involved in regulation of sprouting angiogenesis. Predicted to act upstream of or within several processes, including calcium-ion regulated exocytosis; hemostasis; and inflammatory response. Predicted to be active in plasma membrane. Orthologous to human TSPAN18 (tetraspanin 18). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 116.1), Lung (RPKM 84.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tspan18 in Genome Data Viewer
    Location:
    3q31
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (99615465..99755270, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (79160060..79299907, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (82097068..82236694, complement)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene ribosomal oxygenase 2, pseudogene 5 Neighboring gene tumor protein p53 inducible protein 11 Neighboring gene uncharacterized LOC120101602 Neighboring gene uncharacterized LOC134486408

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    acts_upstream_of_or_within calcium-ion regulated exocytosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within establishment of localization in cell ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within hemostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within inflammatory response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of sprouting angiogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    tetraspanin-18

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107750.2 → NP_001101220.1  tetraspanin-18

      See identical proteins and their annotated locations for NP_001101220.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A6HNI6, D4A3U2
      Related
      ENSRNOP00000011650.5, ENSRNOT00000011650.7
      Conserved Domains (2) summary
      cd03156
      Location:105 → 218
      uroplakin_I_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), uroplakin_I_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
      pfam00335
      Location:10 → 243
      Tetraspannin; Tetraspanin family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      99615465..99755270 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039104912.2 → XP_038960840.1  tetraspanin-18 isoform X1

      UniProtKB/TrEMBL
      A6HNI6, D4A3U2
      Conserved Domains (2) summary
      cd03156
      Location:105 → 218
      uroplakin_I_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), uroplakin_I_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
      pfam00335
      Location:10 → 243
      Tetraspannin; Tetraspanin family

    2. XM_006234574.5 → XP_006234636.1  tetraspanin-18 isoform X1

      See identical proteins and their annotated locations for XP_006234636.1

      UniProtKB/TrEMBL
      A6HNI6, D4A3U2
      Conserved Domains (2) summary
      cd03156
      Location:105 → 218
      uroplakin_I_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), uroplakin_I_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
      pfam00335
      Location:10 → 243
      Tetraspannin; Tetraspanin family

    3. XM_039104911.2 → XP_038960839.1  tetraspanin-18 isoform X1

      UniProtKB/TrEMBL
      A6HNI6, D4A3U2
      Conserved Domains (2) summary
      cd03156
      Location:105 → 218
      uroplakin_I_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), uroplakin_I_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
      pfam00335
      Location:10 → 243
      Tetraspannin; Tetraspanin family
    Nucleotide Protein Strain
    Heading Accession and Version

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