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    Pkd2 polycystin 2, transient receptor potential cation channel [ Rattus norvegicus (Norway rat) ]

    Gene ID: 498328, updated on 9-Dec-2024

    Summary

    Official Symbol
    Pkd2provided by RGD
    Official Full Name
    polycystin 2, transient receptor potential cation channelprovided by RGD
    Primary source
    RGD:1559992
    See related
    AllianceGenome:RGD:1559992
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Trpp2; RGD1559992
    Summary
    Enables muscle alpha-actinin binding activity. Involved in positive regulation of cytosolic calcium ion concentration. Predicted to be located in several cellular components, including basal cortex; endoplasmic reticulum membrane; and microtubule cytoskeleton. Predicted to be part of cation channel complex and polycystin complex. Predicted to be active in membrane. Biomarker of acute kidney failure. Human ortholog(s) of this gene implicated in autosomal dominant polycystic kidney disease; intracranial aneurysm; polycystic kidney disease; polycystic kidney disease 2; and retinal degeneration. Orthologous to human PKD2 (polycystin 2, transient receptor potential cation channel). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 188.3), Adrenal (RPKM 164.1) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Pkd2 in Genome Data Viewer
    Location:
    14p22
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (5541821..5585140, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (5237135..5280455, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (6602004..6645257, complement)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134481818 Neighboring gene THO complex subunit 2-like Neighboring gene secreted phosphoprotein 1 Neighboring gene uncharacterized LOC134481890

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    General gene information

    Gene Ontology Provided by RGD

    Items 1 - 25 of 31
    Function Evidence Code Pubs
    enables ATPase binding  
    enables HLH domain binding  
    enables actinin binding  
    enables alpha-actinin binding PubMed 
    contributes_to calcium channel activity  
    enables calcium channel activity  
    enables calcium ion binding  
    enables calcium ion binding  
    enables calcium-induced calcium release activity  
    enables channel activity  
    enables cytoskeletal protein binding  
    enables identical protein binding  
    enables monoatomic cation channel activity  
    enables muscle alpha-actinin binding  
    enables muscle alpha-actinin binding PubMed 
    enables outward rectifier potassium channel activity  
    enables phosphoprotein binding  
    enables potassium channel activity  
    enables potassium channel activity  
    enables protein homodimerization activity  
    enables signaling receptor binding  
    enables signaling receptor binding  
    enables transcription regulator inhibitor activity  
    enables transmembrane transporter binding  
    enables voltage-gated calcium channel activity  
    enables voltage-gated calcium channel activity  
    enables voltage-gated monoatomic cation channel activity  
    enables voltage-gated monoatomic ion channel activity  
    enables voltage-gated potassium channel activity  
    enables voltage-gated sodium channel activity  
    enables voltage-gated sodium channel activity  
    Items 1 - 25 of 31
    Items 1 - 25 of 66
    Process Evidence Code Pubs
    involved_in Wnt signaling pathway  
    involved_in aorta development  
    involved_in branching involved in ureteric bud morphogenesis  
    involved_in calcium ion transmembrane transport  
    acts_upstream_of_or_within calcium ion transport  
    involved_in calcium ion transport  
    involved_in calcium-mediated signaling  
    involved_in cell surface receptor signaling pathway  
    acts_upstream_of_or_within cell surface receptor signaling pathway via JAK-STAT  
    involved_in cell surface receptor signaling pathway via JAK-STAT  
    involved_in cellular response to cAMP  
    involved_in cellular response to calcium ion  
    involved_in cellular response to fluid shear stress  
    involved_in cellular response to hydrostatic pressure  
    involved_in cellular response to osmotic stress  
    acts_upstream_of_or_within cilium organization  
    involved_in detection of mechanical stimulus  
    acts_upstream_of_or_within detection of mechanical stimulus  
    involved_in detection of nodal flow  
    acts_upstream_of_or_within determination of left/right symmetry  
    involved_in determination of liver left/right asymmetry  
    acts_upstream_of_or_within embryonic placenta development  
    involved_in embryonic placenta development  
    acts_upstream_of_or_within establishment of localization in cell  
    acts_upstream_of_or_within heart development  
    involved_in heart development  
    involved_in heart looping  
    involved_in inorganic cation transmembrane transport  
    acts_upstream_of_or_within intracellular calcium ion homeostasis  
    acts_upstream_of_or_within kidney development  
    acts_upstream_of_or_within liver development  
    involved_in liver development  
    involved_in mesonephric duct development  
    involved_in mesonephric tubule development  
    involved_in metanephric S-shaped body morphogenesis  
    involved_in metanephric ascending thin limb development  
    involved_in metanephric cortex development  
    involved_in metanephric cortical collecting duct development  
    involved_in metanephric distal tubule development  
    involved_in metanephric mesenchyme development  
    involved_in metanephric part of ureteric bud development  
    involved_in metanephric smooth muscle tissue development  
    acts_upstream_of negative regulation of G1/S transition of mitotic cell cycle  
    acts_upstream_of_or_within negative regulation of ryanodine-sensitive calcium-release channel activity  
    involved_in neural tube development  
    involved_in placenta blood vessel development  
    involved_in positive regulation of cytosolic calcium ion concentration PubMed 
    involved_in positive regulation of gene expression  
    involved_in positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity  
    involved_in positive regulation of nitric oxide biosynthetic process  
    involved_in positive regulation of transcription by RNA polymerase II  
    involved_in potassium ion transmembrane transport  
    involved_in potassium ion transmembrane transport  
    involved_in protein heterotetramerization  
    involved_in protein homotetramerization  
    involved_in protein tetramerization  
    involved_in regulation of calcium ion import  
    acts_upstream_of_or_within regulation of cell cycle  
    involved_in regulation of cell population proliferation  
    involved_in release of sequestered calcium ion into cytosol  
    acts_upstream_of_or_within release of sequestered calcium ion into cytosol  
    involved_in release of sequestered calcium ion into cytosol  
    involved_in renal artery morphogenesis  
    involved_in renal tubule morphogenesis  
    involved_in sodium ion transmembrane transport  
    involved_in spinal cord development  
    Items 1 - 25 of 66
    Items 1 - 20 of 29
    Component Evidence Code Pubs
    located_in Golgi apparatus  
    located_in basal cortex  
    located_in basal plasma membrane  
    located_in basolateral plasma membrane  
    part_of cation channel complex  
    located_in cell-cell junction  
    located_in ciliary basal body  
    located_in ciliary membrane  
    located_in cilium  
    located_in cytoplasm  
    located_in cytoplasmic side of endoplasmic reticulum membrane  
    located_in cytoplasmic vesicle membrane  
    located_in cytosol  
    located_in cytosol  
    located_in endoplasmic reticulum  
    located_in endoplasmic reticulum membrane  
    located_in extracellular exosome  
    located_in lamellipodium  
    located_in lumenal side of endoplasmic reticulum membrane  
    is_active_in membrane  
    located_in membrane  
    located_in microtubule cytoskeleton  
    located_in migrasome  
    located_in mitotic spindle  
    located_in motile cilium  
    located_in non-motile cilium  
    located_in plasma membrane  
    part_of polycystin complex  
    located_in spindle microtubule  
    Items 1 - 20 of 29

    General protein information

    Preferred Names
    polycystin-2
    Names
    polycystic kidney disease 2 (autosomal dominant)
    polycystic kidney disease 2 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001191934.1NP_001178863.1  polycystin-2

      See identical proteins and their annotated locations for NP_001178863.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000014
      UniProtKB/TrEMBL
      A6K5R6, D4A5F1
      Conserved Domains (2) summary
      pfam08016
      Location:265685
      PKD_channel; Polycystin cation channel
      cl08302
      Location:730776
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      5541821..5585140 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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