Tfb1m transcription factor B1, mitochondrial [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Tfb1mprovided by RGD
Official Full Name: transcription factor B1, mitochondrialprovided by RGD
Primary source: RGD:727795
See related: EnsemblRapid:ENSRNOG00000056223 AllianceGenome:RGD:727795
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable S-adenosyl-L-methionine binding activity; mitochondrial transcription factor activity; and rRNA (adenine-N6,N6-)-dimethyltransferase activity. Predicted to be involved in rRNA methylation and transcription initiation at mitochondrial promoter. Predicted to be located in mitochondrial nucleoid. Predicted to be active in mitochondrial matrix. Orthologous to human TFB1M (transcription factor B1, mitochondrial). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 101.0), Kidney (RPKM 88.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q11

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (46520510..46567004, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (44115240..44161737, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (44433116..44474674, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables S-adenosyl-L-methionine binding	IEA Inferred from Electronic Annotation more info
enables S-adenosyl-L-methionine binding	ISO Inferred from Sequence Orthology more info
enables S-adenosyl-L-methionine binding	ISS Inferred from Sequence or Structural Similarity more info
enables mitochondrial transcription factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables rRNA (adenine-N6,N6-)-dimethyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables rRNA (adenine-N6,N6-)-dimethyltransferase activity	IEA Inferred from Electronic Annotation more info
enables rRNA (adenine-N6,N6-)-dimethyltransferase activity	ISO Inferred from Sequence Orthology more info
enables rRNA (adenine-N6,N6-)-dimethyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in rRNA methylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in rRNA methylation	IEA Inferred from Electronic Annotation more info
involved_in rRNA methylation	ISO Inferred from Sequence Orthology more info
involved_in rRNA methylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in transcription initiation at mitochondrial promoter	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in mitochondrial matrix	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial nucleoid	IEA Inferred from Electronic Annotation more info
located_in mitochondrial nucleoid	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info	PubMed

General protein information

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Preferred Names: dimethyladenosine transferase 1, mitochondrial

Names: S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase 1; mitochondrial 12S rRNA dimethylase 1; mitochondrial transcription factor B1; mtTFB1

NP_852139.2

EC 2.1.1.-

XP_038966581.1

EC 2.1.1.-

XP_038966589.1

EC 2.1.1.-

XP_038966599.1

EC 2.1.1.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_181474.2 → NP_852139.2 dimethyladenosine transferase 1, mitochondrial

See identical proteins and their annotated locations for NP_852139.2

Status: PROVISIONAL

Source sequence(s)

BC070907

UniProtKB/Swiss-Prot

Q6IRI6, Q811P6

UniProtKB/TrEMBL

A0A0G2JZ68, A6KIQ6

Related

ENSRNOP00000070930.1, ENSRNOT00000078768.3

Conserved Domains (1) summary

PRK00274
Location:15 → 310

ksgA; 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase RsmA

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

46520510..46567004 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039110671.2 → XP_038966599.1 dimethyladenosine transferase 1, mitochondrial isoform X3

Conserved Domains (1) summary

cl17173
Location:1 → 139

AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
XM_039110653.2 → XP_038966581.1 dimethyladenosine transferase 1, mitochondrial isoform X1

Conserved Domains (1) summary

cl17173
Location:15 → 222

AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
XM_039110661.2 → XP_038966589.1 dimethyladenosine transferase 1, mitochondrial isoform X2

Conserved Domains (1) summary

cl17173
Location:15 → 223

AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...