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    Rab17 RAB17, member RAS oncogene family [ Rattus norvegicus (Norway rat) ]

    Gene ID: 503269, updated on 9-Dec-2024

    Summary

    Official Symbol
    Rab17provided by RGD
    Official Full Name
    RAB17, member RAS oncogene familyprovided by RGD
    Primary source
    RGD:1562478
    See related
    EnsemblRapid:ENSRNOG00000052979 AllianceGenome:RGD:1562478
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1562478
    Summary
    Predicted to enable GDP binding activity and GTPase activity. Predicted to be involved in several processes, including immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor; plasma membrane bounded cell projection assembly; and regulation of plasma membrane bounded cell projection organization. Predicted to be located in several cellular components, including apical plasma membrane; basolateral plasma membrane; and cytoplasmic vesicle. Predicted to be active in several cellular components, including endosome; glutamatergic synapse; and postsynapse. Orthologous to human RAB17 (RAB17, member RAS oncogene family). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 321.9), Liver (RPKM 163.7) and 1 other tissue See more
    Orthologs
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    Genomic context

    See Rab17 in Genome Data Viewer
    Location:
    9q36
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (99001044..99014340, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (91552924..91566759, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (98118907..98131883, complement)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene melanophilin Neighboring gene prolactin releasing hormone Neighboring gene LRR binding FLII interacting protein 1 Neighboring gene RNA binding motif protein 44

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GDP binding  
    enables GTP binding  
    enables GTPase activity  
    enables GTPase activity  
    Process Evidence Code Pubs
    involved_in anterograde dendritic transport  
    involved_in cilium assembly  
    involved_in endocytic recycling  
    involved_in endocytic recycling  
    NOT involved_in endocytosis  
    involved_in establishment of melanosome localization  
    involved_in filopodium assembly  
    involved_in immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor  
    involved_in intracellular protein transport  
    involved_in melanosome transport  
    involved_in regulation of dendrite development  
    involved_in regulation of filopodium assembly  
    involved_in regulation of synapse assembly  
    involved_in transcytosis  
    Component Evidence Code Pubs
    located_in apical plasma membrane  
    located_in basolateral plasma membrane  
    located_in dendrite  
    located_in dendrite cytoplasm  
    is_active_in early endosome  
    NOT located_in early endosome  
    located_in endocytic vesicle  
    is_active_in endomembrane system  
    is_active_in glutamatergic synapse  
    located_in melanosome  
    located_in neuronal cell body  
    is_active_in plasma membrane  
    is_active_in postsynapse  
    located_in recycling endosome  
    is_active_in recycling endosome membrane  
    located_in recycling endosome membrane  
    located_in synaptic vesicle membrane  

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001109363.2 → NP_001102833.1  ras-related protein Rab-17

      See identical proteins and their annotated locations for NP_001102833.1

      Status: PROVISIONAL

      Source sequence(s)
      BC167022
      UniProtKB/TrEMBL
      A0A0G2JTD9, A0A9K3Y7P9, B2RZ46
      Related
      ENSRNOP00000068669.2, ENSRNOT00000079446.3
      Conserved Domains (1) summary
      cd01860
      Location:21 → 181
      Rab5_related; Rab-related GTPase family includes Rab5 and Rab22; regulates early endosome fusion

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      99001044..99014340 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039084134.2 → XP_038940062.1  ras-related protein Rab-17 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JTD9, A0A9K3Y7P9, B2RZ46
      Conserved Domains (1) summary
      cd01860
      Location:21 → 181
      Rab5_related; Rab-related GTPase family includes Rab5 and Rab22; regulates early endosome fusion
    2. XM_039084135.2 → XP_038940063.1  ras-related protein Rab-17 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JTD9, A0A9K3Y7P9, B2RZ46
      Conserved Domains (1) summary
      cd01860
      Location:21 → 181
      Rab5_related; Rab-related GTPase family includes Rab5 and Rab22; regulates early endosome fusion
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