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    Plcb4 phospholipase C, beta 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25031, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Plcb4provided by RGD
    Official Full Name
    phospholipase C, beta 4provided by RGD
    Primary source
    RGD:3345
    See related
    EnsemblRapid:ENSRNOG00000033119 AllianceGenome:RGD:3345
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Beta4aa; RATBETA4AA
    Summary
    Enables mitogen-activated protein kinase binding activity. Involved in negative regulation of potassium ion transport. Predicted to be located in dendrite; nucleus; and plasma membrane. Predicted to be active in several cellular components, including glutamatergic synapse; parallel fiber to Purkinje cell synapse; and postsynaptic density. Orthologous to human PLCB4 (phospholipase C beta 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 141.5), Heart (RPKM 133.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Plcb4 in Genome Data Viewer
    Location:
    3q36
    Exon count:
    45
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (143405721..143775129)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (122952965..123322522)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (128601163..128971720)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene mRNA turnover protein 4 homolog Neighboring gene uncharacterized LOC120101678 Neighboring gene uncharacterized LOC134486450 Neighboring gene U6 spliceosomal RNA Neighboring gene lysosomal-associated membrane protein family, member 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cloning of cDNA encoding rat phospholipase C-beta 4, a new member of the phospholipase C. Kim MJ, et al. Biochem Biophys Res Commun, 1993 Jul 30. PMID 7688223
    2. Purification, molecular cloning, and sequencing of phospholipase C-beta 4. Lee CW, et al. J Biol Chem, 1993 Oct 5. PMID 8407970
    3. A cytosolic, galphaq- and betagamma-insensitive splice variant of phospholipase C-beta4. Kim MJ, et al. J Biol Chem, 1998 Feb 6. PMID 9452490
    4. A unique isoform of phospholipase Cbeta4 highly expressed in the cerebellum and eye. Adamski FM, et al. Biochim Biophys Acta, 1999 Jan 18. PMID 9931434
    5. Expression of phospholipase C-beta4 in rat circumvallate taste buds. Toyono T, et al. Chem Senses, 2005 Jan. PMID 15738151

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. This study demonistrated that Plcb4 distribuate in rat cerebellum.
      Title: Differential distribution of phospholipase C beta isoforms and diaglycerol kinase-beta in rodents cerebella corroborates the division of unipolar brush cells into two major subtypes.
    2. functional roles of DGK in the pituitary intermediate lobe
      Title: Signaling cascade of diacylglycerol kinase β in the pituitary intermediate lobe: dopamine D2 receptor/phospholipase Cβ4/diacylglycerol kinase β/protein kinase Cα.
    3. Presence of PLCbeta(4) in the heart and in HL-1 cardiomyocytes showing a different species-dependent pattern of expression of the PLCbeta((1-4)) transcripts.
      Title: Phospholipase Cbeta4 isozyme is expressed in human, rat, and murine heart left ventricles and in HL-1 cardiomyocytes.
    4. analysis of phospholipase C-beta4 expression in rat circumvallate taste buds
      Title: Expression of phospholipase C-beta4 in rat circumvallate taste buds.
    5. Stimulation of 5-HT(2) receptors in prefrontal pyramidal neurons inhibits Ca(v)1.2 L type Ca(2+) currents via a PLCbeta/IP3/calcineurin signaling cascade.
      Title: Stimulation of 5-HT(2) receptors in prefrontal pyramidal neurons inhibits Ca(v)1.2 L type Ca(2+) currents via a PLCbeta/IP3/calcineurin signaling cascade.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mitogen-activated protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables phosphatidylinositol phospholipase C activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylinositol phospholipase C activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lipid catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in modulation of chemical synaptic transmission IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in modulation of chemical synaptic transmission ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of potassium ion transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in phosphatidylinositol metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phosphatidylinositol-mediated signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phospholipase C-activating endothelin receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in phospholipase C-activating endothelin receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in phototransduction NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in release of sequestered calcium ion into cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in dendrite IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in dendrite ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in glutamatergic synapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in parallel fiber to Purkinje cell synapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in parallel fiber to Purkinje cell synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in postsynapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in postsynaptic density IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in postsynaptic density ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in postsynaptic density ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in smooth endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in smooth endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in smooth endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4
    Names
    PLC-beta-4
    phosphoinositide phospholipase C
    phosphoinositide phospholipase C-beta-4
    NP_077329.2
    XP_006235145.1
    XP_006235147.1
    XP_006235150.1
    XP_006235156.1
    XP_038960245.1
    XP_038960247.1
    XP_038960248.1
    XP_038960249.1
    XP_038960250.1
    XP_038960251.1
    XP_038960252.1
    XP_038960253.1
    XP_038960256.1
    XP_063139199.1
    XP_063139200.1
    XP_063139201.1
    XP_063139202.1
    XP_063139203.1
    XP_063139204.1
    XP_063139205.1
    XP_063139206.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001431415.1 → NP_001418344.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform a

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A0A8I5Y961, A6HQJ1

    2. NM_001431416.1 → NP_001418345.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform b

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A0A8I5Y961, D4A8C5

    3. NM_001431417.1 → NP_001418346.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform b

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A0A8I5Y961, D4A8C5

    4. NM_001431418.1 → NP_001418347.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform b

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A0A8I5Y961, D4A8C5

    5. NM_001431419.1 → NP_001418348.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform d

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/Swiss-Prot
      O88356, Q9QW07, Q9Z0G6
      UniProtKB/TrEMBL
      A6HQJ4

    6. NM_024353.3 → NP_077329.2  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform c

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/Swiss-Prot
      O88356, Q9QW07, Q9Z0G6
      UniProtKB/TrEMBL
      F1LNK2
      Conserved Domains (6) summary
      PTZ00121
      Location:840 → 1171
      PTZ00121; MAEBL; Provisional
      cd00275
      Location:703 → 819
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08591
      Location:312 → 669
      PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
      cd13361
      Location:17 → 143
      PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
      cd16211
      Location:148 → 300
      EFh_PI-PLCbeta4; EF-hand motif found in phosphoinositide phospholipase C beta 4 (PI-PLC-beta4)
      pfam06631
      Location:915 → 956
      DUF1154; Protein of unknown function (DUF1154)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      143405721..143775129
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063283129.1 → XP_063139199.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1

      UniProtKB/TrEMBL
      A0A8I5Y961, D4A8C5

    2. XM_063283132.1 → XP_063139202.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1

      UniProtKB/TrEMBL
      A0A8I5Y961, D4A8C5

    3. XM_063283131.1 → XP_063139201.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1

      UniProtKB/TrEMBL
      A0A8I5Y961, D4A8C5

    4. XM_006235085.5 → XP_006235147.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1

      See identical proteins and their annotated locations for XP_006235147.1

      UniProtKB/TrEMBL
      A0A8I5Y961, D4A8C5
      Conserved Domains (6) summary
      PTZ00121
      Location:859 → 1206
      PTZ00121; MAEBL; Provisional
      cd00275
      Location:714 → 830
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08591
      Location:312 → 680
      PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
      cd13361
      Location:17 → 143
      PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
      cd16211
      Location:148 → 300
      EFh_PI-PLCbeta4; EF-hand motif found in phosphoinositide phospholipase C beta 4 (PI-PLC-beta4)
      pfam06631
      Location:926 → 967
      DUF1154; Protein of unknown function (DUF1154)

    5. XM_039104325.2 → XP_038960253.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1

      UniProtKB/TrEMBL
      A0A8I5Y961, D4A8C5
      Conserved Domains (6) summary
      PTZ00121
      Location:859 → 1206
      PTZ00121; MAEBL; Provisional
      cd00275
      Location:714 → 830
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08591
      Location:312 → 680
      PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
      cd13361
      Location:17 → 143
      PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
      cd16211
      Location:148 → 300
      EFh_PI-PLCbeta4; EF-hand motif found in phosphoinositide phospholipase C beta 4 (PI-PLC-beta4)
      pfam06631
      Location:926 → 967
      DUF1154; Protein of unknown function (DUF1154)

    6. XM_063283134.1 → XP_063139204.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X2

      UniProtKB/TrEMBL
      A0A8I5Y961, A6HQJ1
      Related
      ENSRNOP00000087693.2, ENSRNOT00000097572.2

    7. XM_039104323.2 → XP_038960251.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1

      UniProtKB/TrEMBL
      A0A8I5Y961, D4A8C5
      Conserved Domains (6) summary
      PTZ00121
      Location:859 → 1206
      PTZ00121; MAEBL; Provisional
      cd00275
      Location:714 → 830
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08591
      Location:312 → 680
      PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
      cd13361
      Location:17 → 143
      PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
      cd16211
      Location:148 → 300
      EFh_PI-PLCbeta4; EF-hand motif found in phosphoinositide phospholipase C beta 4 (PI-PLC-beta4)
      pfam06631
      Location:926 → 967
      DUF1154; Protein of unknown function (DUF1154)

    8. XM_039104321.2 → XP_038960249.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1

      Conserved Domains (6) summary
      PTZ00121
      Location:859 → 1206
      PTZ00121; MAEBL; Provisional
      cd00275
      Location:714 → 830
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08591
      Location:312 → 680
      PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
      cd13361
      Location:17 → 143
      PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
      cd16211
      Location:148 → 300
      EFh_PI-PLCbeta4; EF-hand motif found in phosphoinositide phospholipase C beta 4 (PI-PLC-beta4)
      pfam06631
      Location:926 → 967
      DUF1154; Protein of unknown function (DUF1154)

    9. XM_039104317.2 → XP_038960245.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1

      Conserved Domains (6) summary
      PTZ00121
      Location:859 → 1206
      PTZ00121; MAEBL; Provisional
      cd00275
      Location:714 → 830
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08591
      Location:312 → 680
      PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
      cd13361
      Location:17 → 143
      PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
      cd16211
      Location:148 → 300
      EFh_PI-PLCbeta4; EF-hand motif found in phosphoinositide phospholipase C beta 4 (PI-PLC-beta4)
      pfam06631
      Location:926 → 967
      DUF1154; Protein of unknown function (DUF1154)

    10. XM_006235083.5 → XP_006235145.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1

      Related
      ENSRNOP00000045972.3, ENSRNOT00000045393.6
      Conserved Domains (6) summary
      PTZ00121
      Location:859 → 1206
      PTZ00121; MAEBL; Provisional
      cd00275
      Location:714 → 830
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08591
      Location:312 → 680
      PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
      cd13361
      Location:17 → 143
      PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
      cd16211
      Location:148 → 300
      EFh_PI-PLCbeta4; EF-hand motif found in phosphoinositide phospholipase C beta 4 (PI-PLC-beta4)
      pfam06631
      Location:926 → 967
      DUF1154; Protein of unknown function (DUF1154)

    11. XM_063283136.1 → XP_063139206.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X3

      UniProtKB/Swiss-Prot
      O88356, Q9QW07, Q9Z0G6

    12. XM_063283135.1 → XP_063139205.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X2

      Related
      ENSRNOP00000076875.2, ENSRNOT00000105709.2

    13. XM_006235094.5 → XP_006235156.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X4

      Related
      ENSRNOP00000048553.4, ENSRNOT00000042853.7
      Conserved Domains (7) summary
      cd00275
      Location:702 → 818
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08591
      Location:312 → 668
      PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
      PLN02228
      Location:218 → 807
      PLN02228; Phosphoinositide phospholipase C
      cd13361
      Location:17 → 143
      PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
      pfam06631
      Location:914 → 954
      DUF1154; Protein of unknown function (DUF1154)
      pfam09279
      Location:221 → 312
      EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
      pfam12474
      Location:1048 → 1160
      PKK; Polo kinase kinase

    14. XM_039104322.2 → XP_038960250.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1

      UniProtKB/TrEMBL
      A0A8I5Y961, D4A8C5
      Conserved Domains (6) summary
      PTZ00121
      Location:859 → 1206
      PTZ00121; MAEBL; Provisional
      cd00275
      Location:714 → 830
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08591
      Location:312 → 680
      PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
      cd13361
      Location:17 → 143
      PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
      cd16211
      Location:148 → 300
      EFh_PI-PLCbeta4; EF-hand motif found in phosphoinositide phospholipase C beta 4 (PI-PLC-beta4)
      pfam06631
      Location:926 → 967
      DUF1154; Protein of unknown function (DUF1154)

    15. XM_039104320.2 → XP_038960248.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1

      UniProtKB/TrEMBL
      A0A8I5Y961, D4A8C5
      Conserved Domains (6) summary
      PTZ00121
      Location:859 → 1206
      PTZ00121; MAEBL; Provisional
      cd00275
      Location:714 → 830
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08591
      Location:312 → 680
      PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
      cd13361
      Location:17 → 143
      PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
      cd16211
      Location:148 → 300
      EFh_PI-PLCbeta4; EF-hand motif found in phosphoinositide phospholipase C beta 4 (PI-PLC-beta4)
      pfam06631
      Location:926 → 967
      DUF1154; Protein of unknown function (DUF1154)

    16. XM_039104324.2 → XP_038960252.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1

      UniProtKB/TrEMBL
      A0A8I5Y961, D4A8C5
      Conserved Domains (6) summary
      PTZ00121
      Location:859 → 1206
      PTZ00121; MAEBL; Provisional
      cd00275
      Location:714 → 830
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08591
      Location:312 → 680
      PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
      cd13361
      Location:17 → 143
      PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
      cd16211
      Location:148 → 300
      EFh_PI-PLCbeta4; EF-hand motif found in phosphoinositide phospholipase C beta 4 (PI-PLC-beta4)
      pfam06631
      Location:926 → 967
      DUF1154; Protein of unknown function (DUF1154)

    17. XM_006235088.5 → XP_006235150.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1

      See identical proteins and their annotated locations for XP_006235150.1

      UniProtKB/TrEMBL
      A0A8I5Y961, D4A8C5
      Conserved Domains (6) summary
      PTZ00121
      Location:859 → 1206
      PTZ00121; MAEBL; Provisional
      cd00275
      Location:714 → 830
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08591
      Location:312 → 680
      PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
      cd13361
      Location:17 → 143
      PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
      cd16211
      Location:148 → 300
      EFh_PI-PLCbeta4; EF-hand motif found in phosphoinositide phospholipase C beta 4 (PI-PLC-beta4)
      pfam06631
      Location:926 → 967
      DUF1154; Protein of unknown function (DUF1154)

    18. XM_063283133.1 → XP_063139203.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X2

      UniProtKB/TrEMBL
      A0A8I5Y961, A6HQJ1

    19. XM_039104319.2 → XP_038960247.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1

      UniProtKB/TrEMBL
      A0A8I5Y961, D4A8C5
      Conserved Domains (6) summary
      PTZ00121
      Location:859 → 1206
      PTZ00121; MAEBL; Provisional
      cd00275
      Location:714 → 830
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08591
      Location:312 → 680
      PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
      cd13361
      Location:17 → 143
      PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
      cd16211
      Location:148 → 300
      EFh_PI-PLCbeta4; EF-hand motif found in phosphoinositide phospholipase C beta 4 (PI-PLC-beta4)
      pfam06631
      Location:926 → 967
      DUF1154; Protein of unknown function (DUF1154)

    20. XM_063283130.1 → XP_063139200.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1

      UniProtKB/TrEMBL
      A0A8I5Y961, D4A8C5

    21. XM_039104328.2 → XP_038960256.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X5

      Conserved Domains (4) summary
      PTZ00121
      Location:591 → 938
      PTZ00121; MAEBL; Provisional
      cd08591
      Location:44 → 412
      PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
      PLN02228
      Location:16 → 551
      PLN02228; Phosphoinositide phospholipase C
      pfam06631
      Location:658 → 699
      DUF1154; Protein of unknown function (DUF1154)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9QW07.2 GenPept UniProtKB/Swiss-Prot:Q9QW07

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