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    Klkb1 kallikrein B1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25048, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Klkb1provided by RGD
    Official Full Name
    kallikrein B1provided by RGD
    Primary source
    RGD:67382
    See related
    EnsemblRapid:ENSRNOG00000014118 AllianceGenome:RGD:67382
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    PK; Klk3; Kalp1; KALP15
    Summary
    Predicted to enable serine-type endopeptidase activity. Involved in liver regeneration. Located in extracellular space. Used to study inflammatory bowel disease. Biomarker of liver cirrhosis. Human ortholog(s) of this gene implicated in lupus nephritis and systemic lupus erythematosus. Orthologous to human KLKB1 (kallikrein B1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Liver (RPKM 700.7), Adrenal (RPKM 144.3) and 4 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Klkb1 in Genome Data Viewer
    Location:
    16q11
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (53690180..53714570)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (46958634..46982054)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (50151127..50175407)

    Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene cytochrome P450, family 4, subfamily v, polypeptide 3 Neighboring gene tubulin, alpha 1B, pseudogene 9 Neighboring gene coagulation factor XI Neighboring gene small ribosomal subunit protein eS26-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Plasma Kallikrein Contributes to Intracerebral Hemorrhage and Hypertension in Stroke-Prone Spontaneously Hypertensive Rats. Guan J, et al. Transl Stroke Res, 2022 Apr. PMID 34241810, Free PMC Article
    2. PF-04886847 (an inhibitor of plasma kallikrein) attenuates inflammatory mediators and activation of blood coagulation in rat model of lipopolysaccharide (LPS)-induced sepsis. Kolte D, et al. Cardiovasc Hematol Agents Med Chem, 2012 Jun. PMID 22352684, Free PMC Article
    3. [Evaluation of protein compliance in patients with chronic renal insufficiency undergoing hemodialysis treatment]. Pace V, et al. Riv Eur Sci Med Farmacol, 1992 May-Jun. PMID 1298973
    4. Kallikrein genes are associated with lupus and glomerular basement membrane-specific antibody-induced nephritis in mice and humans. Liu K, et al. J Clin Invest, 2009 Apr. PMID 19307730, Free PMC Article
    5. Changes in plasma prekallikrein activity, blood pressure, and left ventricular thickness in hypertensive and normotensive diabetic rats. Sharma JN, et al. Methods Find Exp Clin Pharmacol, 2007 Mar. PMID 17440623

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Plasma Kallikrein Contributes to Intracerebral Hemorrhage and Hypertension in Stroke-Prone Spontaneously Hypertensive Rats.
      Title: Plasma Kallikrein Contributes to Intracerebral Hemorrhage and Hypertension in Stroke-Prone Spontaneously Hypertensive Rats.
    2. findings suggest for the first time that higher plasma prekallikrein activity may serve as an indicator for predicting high BP and left ventricular hypertrophy in diabetic and hypertensive conditions
      Title: Changes in plasma prekallikrein activity, blood pressure, and left ventricular thickness in hypertensive and normotensive diabetic rats.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC108748

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in blood coagulation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in fibrinolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in inflammatory response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in liver regeneration IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in plasminogen activation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in plasminogen activation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of fibrinolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of fibrinolysis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    plasma kallikrein
    Names
    fletcher factor
    kallikrein B, plasma 1
    kininogenin
    plasma prekallikrein
    NP_036857.2
    XP_006253183.1
    XP_008769475.2
    XP_063131126.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012725.2 → NP_036857.2  plasma kallikrein precursor

      See identical proteins and their annotated locations for NP_036857.2

      Status: PROVISIONAL

      Source sequence(s)
      BC089815
      UniProtKB/Swiss-Prot
      P14272
      UniProtKB/TrEMBL
      A6JPR7, F7FQ32, Q5FVS2
      Related
      ENSRNOP00000019237.3, ENSRNOT00000019237.7
      Conserved Domains (3) summary
      smart00223
      Location:21 → 104
      APPLE; APPLE domain
      smart00020
      Location:390 → 621
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:391 → 621
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086034.1 Reference GRCr8

      Range
      53690180..53714570
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006253121.5 → XP_006253183.1  plasma kallikrein isoform X1

      UniProtKB/Swiss-Prot
      P14272
      Conserved Domains (3) summary
      smart00223
      Location:21 → 104
      APPLE; APPLE domain
      smart00020
      Location:377 → 608
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:378 → 608
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

    2. XM_063275056.1 → XP_063131126.1  plasma kallikrein isoform X2

      UniProtKB/TrEMBL
      A6JPR8

    3. XM_008771253.3 → XP_008769475.2  plasma kallikrein isoform X3

      UniProtKB/TrEMBL
      A6JPR8
      Related
      ENSRNOP00000108529.1, ENSRNOT00000121109.1
      Conserved Domains (3) summary
      smart00223
      Location:49 → 132
      APPLE; APPLE domain
      cd00190
      Location:329 → 559
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
      cl00112
      Location:14 → 42
      PAN_APPLE; PAN/APPLE-like domain; present in N-terminal (N) domains of plasminogen/ hepatocyte growth factor proteins, plasma prekallikrein/coagulation factor XI and microneme antigen proteins, plant receptor-like protein kinases, and various nematode and leech ...
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P14272.1 GenPept UniProtKB/Swiss-Prot:P14272

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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