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    Defb4 defensin beta 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 64389, updated on 27-Dec-2024

    Summary

    Official Symbol
    Defb4provided by RGD
    Official Full Name
    defensin beta 4provided by RGD
    Primary source
    RGD:619944
    See related
    EnsemblRapid:ENSRNOG00000013939 AllianceGenome:RGD:619944
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Defb2; Defb3
    Summary
    Predicted to enable CCR6 chemokine receptor binding activity and chemoattractant activity. Predicted to be involved in cell chemotaxis; defense response to Gram-negative bacterium; and defense response to Gram-positive bacterium. Predicted to be active in extracellular space. Orthologous to several human genes including DEFB4A (defensin beta 4A). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward (RPKM 1276.5) See more
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    Genomic context

    See Defb4 in Genome Data Viewer
    Location:
    16q12.5
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (77352911..77356104, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (70650472..70653665, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (75634598..75637789, complement)

    Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134482414 Neighboring gene defensin beta 5 Neighboring gene uncharacterized LOC134482415 Neighboring gene defensin beta 14 Neighboring gene sperm associated antigen 11A

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables CCR6 chemokine receptor binding  
    enables CCR6 chemokine receptor binding  
    enables chemoattractant activity  
    Process Evidence Code Pubs
    involved_in biological_process  
    involved_in cell chemotaxis  
    involved_in chemotaxis  
    involved_in defense response to Gram-negative bacterium  
    involved_in defense response to Gram-positive bacterium  
    involved_in defense response to bacterium  
    involved_in positive chemotaxis  
    Component Evidence Code Pubs
    is_active_in extracellular space  

    General protein information

    Preferred Names
    beta-defensin 4
    Names
    BD-2
    BD-4
    RBD-2
    RBD-4
    beta defensin-2
    beta-defensin 3
    defensin beta 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_022544.2NP_071989.1  beta-defensin 4 precursor

      See identical proteins and their annotated locations for NP_071989.1

      Status: PROVISIONAL

      Source sequence(s)
      AY621374
      UniProtKB/Swiss-Prot
      O88514, Q32ZE9
      UniProtKB/TrEMBL
      A6IWA3
      Related
      ENSRNOP00000054838.1, ENSRNOT00000058029.3
      Conserved Domains (1) summary
      pfam00711
      Location:2861
      Defensin_beta; Beta defensin

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086034.1 Reference GRCr8

      Range
      77352911..77356104 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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