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    Pitpnm1 phosphatidylinositol transfer protein, membrane-associated 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361694, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Pitpnm1provided by RGD
    Official Full Name
    phosphatidylinositol transfer protein, membrane-associated 1provided by RGD
    Primary source
    RGD:1306710
    See related
    EnsemblRapid:ENSRNOG00000018553 AllianceGenome:RGD:1306710
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Pitpnm
    Summary
    Predicted to enable several functions, including phospholipid binding activity; phospholipid transporter activity; and receptor tyrosine kinase binding activity. Predicted to be involved in phospholipid transport. Located in cell body. Orthologous to human PITPNM1 (phosphatidylinositol transfer protein membrane associated 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 292.7), Spleen (RPKM 111.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Pitpnm1 in Genome Data Viewer
    Location:
    1q43
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (210823568..210836989)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (201394099..201407523)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (219348672..219362094)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene calcium binding protein 2 Neighboring gene cyclin-dependent kinase 2 associated protein 2 Neighboring gene aryl-hydrocarbon receptor-interacting protein Neighboring gene transmembrane protein 134 Neighboring gene calcium binding protein 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Phosphatidylinositol transfer protein, cytoplasmic 1 (PITPNC1) binds and transfers phosphatidic acid. Garner K, et al. J Biol Chem, 2012 Sep 14. PMID 22822086, Free PMC Article
    2. Identification of a novel family of targets of PYK2 related to Drosophila retinal degeneration B (rdgB) protein. Lev S, et al. Mol Cell Biol, 1999 Mar. PMID 10022914, Free PMC Article
    3. Structural Analysis of Hippocampal Kinase Signal Transduction. McClatchy DB, et al. ACS Chem Neurosci, 2018 Dec 19. PMID 30053369, Free PMC Article
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC95131

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calcium ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatidic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidic acid binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatidylcholine binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylcholine binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylcholine binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatidylcholine transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylinositol binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylinositol binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylinositol binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatidylinositol transfer activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylinositol transfer activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylinositol transfer activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatidylinositol transfer activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables receptor tyrosine kinase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables receptor tyrosine kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in intermembrane lipid transfer IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phospholipid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phospholipid transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi cisterna membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cell body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cleavage furrow IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intracellular membrane-bounded organelle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lipid droplet IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in midbody IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    membrane-associated phosphatidylinositol transfer protein 1
    Names
    NIR-2
    PITPnm 1
    phosphatidylinositol membrane-associated
    pyk2 N-terminal domain-interacting receptor 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001008369.1 → NP_001008370.1  membrane-associated phosphatidylinositol transfer protein 1

      See identical proteins and their annotated locations for NP_001008370.1

      Status: PROVISIONAL

      Source sequence(s)
      BC085945
      UniProtKB/Swiss-Prot
      Q5U2N3
      UniProtKB/TrEMBL
      A6HYT2
      Related
      ENSRNOP00000025084.3, ENSRNOT00000025084.6
      Conserved Domains (3) summary
      cd08889
      Location:1 → 257
      SRPBCC_PITPNM1-2_like; Lipid-binding SRPBCC domain of mammalian PITPNM1-2 and related proteins (Class IIA PITPs)
      smart00775
      Location:1021 → 1152
      LNS2; This domain is found in Saccharomyces cerevisiae protein SMP2, proteins with an N-terminal lipin domain and phosphatidylinositol transfer proteins
      pfam02862
      Location:687 → 877
      DDHD; DDHD domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      210823568..210836989
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063268158.1 → XP_063124228.1  membrane-associated phosphatidylinositol transfer protein 1 isoform X4

    2. XM_039083713.2 → XP_038939641.1  membrane-associated phosphatidylinositol transfer protein 1 isoform X3

      Conserved Domains (2) summary
      cd08889
      Location:1 → 278
      SRPBCC_PITPNM1-2_like; Lipid-binding SRPBCC domain of mammalian PITPNM1-2 and related proteins (Class IIA PITPs)
      pfam02862
      Location:708 → 898
      DDHD; DDHD domain

    3. XM_039083707.2 → XP_038939635.1  membrane-associated phosphatidylinositol transfer protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AQF3
      Related
      ENSRNOP00000096308.1, ENSRNOT00000105000.2
      Conserved Domains (3) summary
      cd08889
      Location:1 → 278
      SRPBCC_PITPNM1-2_like; Lipid-binding SRPBCC domain of mammalian PITPNM1-2 and related proteins (Class IIA PITPs)
      smart00775
      Location:1042 → 1173
      LNS2; This domain is found in Saccharomyces cerevisiae protein SMP2, proteins with an N-terminal lipin domain and phosphatidylinositol transfer proteins
      pfam02862
      Location:708 → 898
      DDHD; DDHD domain

    4. XM_063268157.1 → XP_063124227.1  membrane-associated phosphatidylinositol transfer protein 1 isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5U2N3.1 GenPept UniProtKB/Swiss-Prot:Q5U2N3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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