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    Kifap3 kinesin-associated protein 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 289168, updated on 4-Jan-2025

    Summary

    Official Symbol
    Kifap3provided by RGD
    Official Full Name
    kinesin-associated protein 3provided by RGD
    Primary source
    RGD:1305191
    See related
    EnsemblRapid:ENSRNOG00000002544 AllianceGenome:RGD:1305191
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable intraciliary transport particle B binding activity; kinesin binding activity; and protein phosphatase binding activity. Predicted to be involved in anterograde dendritic transport of neurotransmitter receptor complex and cilium organization. Predicted to act upstream of or within several processes, including negative regulation of apoptotic process; negative regulation of neuroblast proliferation; and positive regulation of calcium-dependent cell-cell adhesion. Predicted to be located in several cellular components, including microtubule cytoskeleton; periciliary membrane compartment; and photoreceptor cell cilium. Predicted to be part of kinesin II complex. Predicted to be active in several cellular components, including axoneme; ciliary transition zone; and glutamatergic synapse. Orthologous to human KIFAP3 (kinesin associated protein 3). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in Brain (RPKM 471.5), Testes (RPKM 224.5) and 9 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Kifap3 in Genome Data Viewer
    Location:
    13q22
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (78660849..78797821)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (76127702..76264654)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (82072497..82217256)

    Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134481584 Neighboring gene N-terminal Xaa-Pro-Lys N-methyltransferase 2 Neighboring gene uncharacterized LOC120096301 Neighboring gene SCY1 like pseudokinase 3 Neighboring gene FIGNL1 interacting regulator of recombination and mitosis

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables intraciliary transport particle B binding  
    enables kinesin binding  
    enables protein phosphatase binding  
    Process Evidence Code Pubs
    involved_in anterograde dendritic transport of neurotransmitter receptor complex  
    acts_upstream_of apoptotic process  
    acts_upstream_of cardiac muscle cell apoptotic process  
    acts_upstream_of cell population proliferation  
    involved_in cilium organization  
    involved_in microtubule-based movement  
    involved_in microtubule-based process  
    acts_upstream_of_or_within negative regulation of apoptotic process  
    acts_upstream_of_or_within negative regulation of cardiac muscle cell apoptotic process  
    acts_upstream_of_or_within negative regulation of neuroblast proliferation  
    acts_upstream_of_or_within negative regulation of thymocyte apoptotic process  
    acts_upstream_of neuroblast proliferation  
    acts_upstream_of_or_within positive regulation of calcium-dependent cell-cell adhesion  
    acts_upstream_of_or_within protein localization  
    acts_upstream_of thymocyte apoptotic process  
    Component Evidence Code Pubs
    located_in Golgi apparatus  
    is_active_in axoneme  
    located_in axoneme  
    located_in centrosome  
    located_in ciliary basal body  
    is_active_in ciliary transition zone  
    located_in condensed nuclear chromosome  
    located_in dendrite cytoplasm  
    located_in endoplasmic reticulum  
    is_active_in glutamatergic synapse  
    part_of kinesin II complex  
    part_of kinesin II complex  
    located_in microtubule cytoskeleton  
    located_in periciliary membrane compartment  
    located_in photoreceptor connecting cilium  
    located_in photoreceptor inner segment  
    located_in photoreceptor outer segment  
    is_active_in postsynapse  
    located_in spindle microtubule  

    General protein information

    Preferred Names
    kinesin-associated protein 3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001401347.1NP_001388276.1  kinesin-associated protein 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000013
      UniProtKB/TrEMBL
      A0A8I5ZXB9
      Related
      ENSRNOP00000082498.2, ENSRNOT00000112619.2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086031.1 Reference GRCr8

      Range
      78660849..78797821
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039090489.2XP_038946417.1  kinesin-associated protein 3 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K0P1, A0A8I5ZXB9
      Related
      ENSRNOP00000093594.2, ENSRNOT00000095640.2
      Conserved Domains (1) summary
      pfam05804
      Location:29736
      KAP; Kinesin-associated protein (KAP)
    2. XM_039090490.2XP_038946418.1  kinesin-associated protein 3 isoform X2

      UniProtKB/TrEMBL
      A6IDC5, D3ZWA5
      Related
      ENSRNOP00000071523.3, ENSRNOT00000085135.3
      Conserved Domains (1) summary
      pfam05804
      Location:29736
      KAP; Kinesin-associated protein (KAP)
    3. XM_063272116.1XP_063128186.1  kinesin-associated protein 3 isoform X3

      UniProtKB/TrEMBL
      A0A8I5ZXB9
      Related
      ENSRNOP00000063896.5, ENSRNOT00000063810.5

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