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    Fa2h fatty acid 2-hydroxylase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 307855, updated on 9-Dec-2024

    Summary

    Official Symbol
    Fa2hprovided by RGD
    Official Full Name
    fatty acid 2-hydroxylaseprovided by RGD
    Primary source
    RGD:1310347
    See related
    EnsemblRapid:ENSRNOG00000018950 AllianceGenome:RGD:1310347
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Wdr59; RGD1310347
    Summary
    Enables fatty acid 2-hydroxylase activity. Involved in galactosylceramide biosynthetic process. Predicted to be located in membrane. Predicted to be active in endoplasmic reticulum. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 35. Orthologous to human FA2H (fatty acid 2-hydroxylase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 63.1), Brain (RPKM 54.2) and 2 other tissues See more
    Orthologs
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    Genomic context

    See Fa2h in Genome Data Viewer
    Location:
    19q12
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (56222240..56273480, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (39312904..39364153, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (43545380..43596788, complement)

    Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene U6 spliceosomal RNA Neighboring gene ring finger and WD repeat domain 3 Neighboring gene mixed lineage kinase domain like pseudokinase Neighboring gene small nucleolar RNA SNORA17 Neighboring gene WD repeat domain 59 Neighboring gene 60S ribosomal protein L29-like

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 4-hydroxysphinganine ceramide fatty acyl 2-hydroxylase activity  
    enables fatty acid 2-hydroxylase activity  
    enables fatty acid 2-hydroxylase activity PubMed 
    enables fatty acid 2-hydroxylase activity  
    enables fatty acid 2-hydroxylase activity  
    enables free fatty acid 2-hydroxylase activity  
    enables heme binding  
    enables iron ion binding  
    Process Evidence Code Pubs
    acts_upstream_of_or_within central nervous system myelin maintenance  
    involved_in ceramide biosynthetic process  
    involved_in ceramide biosynthetic process  
    involved_in establishment of skin barrier  
    involved_in establishment of skin barrier  
    involved_in fatty acid biosynthetic process  
    involved_in fatty acid metabolic process  
    acts_upstream_of_or_within fatty acid metabolic process  
    involved_in galactosylceramide biosynthetic process  
    involved_in galactosylceramide biosynthetic process PubMed 
    involved_in galactosylceramide biosynthetic process  
    involved_in galactosylceramide biosynthetic process  
    involved_in glucosylceramide biosynthetic process  
    involved_in glucosylceramide biosynthetic process  
    acts_upstream_of_or_within lipid modification  
    acts_upstream_of_or_within peripheral nervous system myelin maintenance  
    involved_in plasma membrane raft organization  
    involved_in plasma membrane raft organization  
    acts_upstream_of_or_within regulation of acinar cell proliferation  
    acts_upstream_of_or_within regulation of hair cycle  
    acts_upstream_of_or_within regulation of sebum secreting cell proliferation  
    acts_upstream_of_or_within sebaceous gland cell differentiation  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum  
    located_in endoplasmic reticulum  
    located_in endoplasmic reticulum membrane  
    located_in membrane  
    located_in membrane  

    General protein information

    Preferred Names
    fatty acid 2-hydroxylase
    Names
    WD repeat domain 59
    fatty acid alpha-hydroxylase
    NP_001129055.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001135583.1NP_001129055.1  fatty acid 2-hydroxylase

      See identical proteins and their annotated locations for NP_001129055.1

      Status: VALIDATED

      Source sequence(s)
      BQ201885, CB610350, CV120060, DQ339484
      UniProtKB/Swiss-Prot
      Q2LAM0
      Related
      ENSRNOP00000025625.6, ENSRNOT00000025625.8
      Conserved Domains (2) summary
      pfam00173
      Location:1286
      Cyt-b5; Cytochrome b5-like Heme/Steroid binding domain
      cl01132
      Location:124372
      FA_hydroxylase; Fatty acid hydroxylase superfamily

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086037.1 Reference GRCr8

      Range
      56222240..56273480 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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