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    Lmbr1l limb development membrane protein 1-like [ Rattus norvegicus (Norway rat) ]

    Gene ID: 300215, updated on 27-Dec-2024

    Summary

    Official Symbol
    Lmbr1lprovided by RGD
    Official Full Name
    limb development membrane protein 1-likeprovided by RGD
    Primary source
    RGD:1309631
    See related
    EnsemblRapid:ENSRNOG00000061607 AllianceGenome:RGD:1309631
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1309631
    Summary
    Predicted to enable transmembrane signaling receptor activity. Predicted to be involved in several processes, including T cell activation; hematopoietic stem cell differentiation; and negative regulation of canonical Wnt signaling pathway. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in plasma membrane. Orthologous to human LMBR1L (limb development membrane protein 1 like). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 107.0), Testes (RPKM 87.6) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Lmbr1l in Genome Data Viewer
    Location:
    7q36
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (131940081..131958832, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (130061136..130078101, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (140585512..140600797, complement)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene tubulin, alpha 1C Neighboring gene RHEB like 1 Neighboring gene ribosomal protein L13, pseudogene 3 Neighboring gene desert hedgehog signaling molecule Neighboring gene tubulin, alpha 1B

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Clone Names

    • MGC109220

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in T cell apoptotic process  
    involved_in T cell differentiation  
    involved_in T cell proliferation  
    involved_in Wnt signaling pathway  
    involved_in hematopoietic stem cell differentiation  
    involved_in negative regulation of canonical Wnt signaling pathway  
    involved_in receptor-mediated endocytosis  
    involved_in receptor-mediated endocytosis  
    involved_in signal transduction  
    involved_in signal transduction  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum membrane  
    is_active_in plasma membrane  
    located_in plasma membrane  

    General protein information

    Preferred Names
    protein LMBR1L
    Names
    limb region 1 like
    limb region 1-like homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013950.1 → NP_001013972.1  protein LMBR1L isoform 2

      See identical proteins and their annotated locations for NP_001013972.1

      Status: PROVISIONAL

      Source sequence(s)
      BC089929
      UniProtKB/TrEMBL
      F1MAN0, Q5FVK3
      Conserved Domains (1) summary
      pfam04791
      Location:28 → 220
      LMBR1; LMBR1-like membrane protein
    2. NM_001395729.1 → NP_001382658.1  protein LMBR1L isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/TrEMBL
      A0A0G2JVJ7
      Related
      ENSRNOP00000069512.1, ENSRNOT00000082375.3
      Conserved Domains (1) summary
      pfam04791
      Location:21 → 452
      LMBR1; LMBR1-like membrane protein

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      131940081..131958832 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039078924.2 → XP_038934852.1  protein LMBR1L isoform X4

      Conserved Domains (1) summary
      pfam04791
      Location:32 → 421
      LMBR1; LMBR1-like membrane protein
    2. XM_039078922.2 → XP_038934850.1  protein LMBR1L isoform X1

      Conserved Domains (1) summary
      pfam04791
      Location:21 → 456
      LMBR1; LMBR1-like membrane protein
    3. XM_017594788.3 → XP_017450277.1  protein LMBR1L isoform X2

      Conserved Domains (1) summary
      pfam04791
      Location:28 → 450
      LMBR1; LMBR1-like membrane protein
    4. XM_039078923.2 → XP_038934851.1  protein LMBR1L isoform X3

      Conserved Domains (1) summary
      pfam04791
      Location:21 → 456
      LMBR1; LMBR1-like membrane protein
    5. XM_063263379.1 → XP_063119449.1  protein LMBR1L isoform X5

      Related
      ENSRNOP00000099174.1, ENSRNOT00000156677.1
    6. XM_039078925.2 → XP_038934853.1  protein LMBR1L isoform X6

      Conserved Domains (1) summary
      pfam04791
      Location:1 → 329
      LMBR1; LMBR1-like membrane protein
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