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    Rab7b Rab7b, member RAS oncogene family [ Rattus norvegicus (Norway rat) ]

    Gene ID: 501854, updated on 9-Dec-2024

    Summary

    Official Symbol
    Rab7bprovided by RGD
    Official Full Name
    Rab7b, member RAS oncogene familyprovided by RGD
    Primary source
    RGD:1562617
    See related
    EnsemblRapid:ENSRNOG00000039754 AllianceGenome:RGD:1562617
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1562617
    Summary
    Predicted to enable GTP binding activity and GTPase activity. Predicted to be involved in several processes, including late endosome to Golgi transport; regulation of gene expression; and regulation of pattern recognition receptor signaling pathway. Predicted to act upstream of or within cellular response to type II interferon. Predicted to be located in trans-Golgi network. Predicted to be active in late endosome; lysosome; and phagocytic vesicle. Orthologous to human RAB7B (RAB7B, member RAS oncogene family). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 43.1), Spleen (RPKM 17.6) and 9 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Rab7b in Genome Data Viewer
    Location:
    13q13
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (45673396..45699798)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (43121168..43147581)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (48456143..48483714)

    Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene arginine vasopressin receptor 1B Neighboring gene cathepsin E Neighboring gene uncharacterized LOC134481493 Neighboring gene uncharacterized LOC103691878 Neighboring gene solute carrier family 26 member 9

    Genomic regions, transcripts, and products

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in late endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in late endosome ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in lysosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in lysosome ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in phagocytic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in phagocytic vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in trans-Golgi network ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    ras-related protein Rab-7b
    NP_001102798.1
    XP_008767713.2
    XP_008767714.2
    XP_017454394.1
    XP_063128624.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001109328.2 → NP_001102798.1  ras-related protein Rab-7b

      See identical proteins and their annotated locations for NP_001102798.1

      Status: VALIDATED

      Source sequence(s)
      FM076322, JAXUCZ010000013
      UniProtKB/TrEMBL
      A6IC28, A6IC29, D4A7A8
      Related
      ENSRNOP00000009280.3, ENSRNOT00000009280.7
      Conserved Domains (1) summary
      cd00154
      Location:9 → 169
      Rab; Ras-related in brain (Rab) family of small guanosine triphosphatases (GTPases)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086031.1 Reference GRCr8

      Range
      45673396..45699798
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017598905.3 → XP_017454394.1  ras-related protein Rab-7b isoform X2

      UniProtKB/TrEMBL
      A0A8I6A7M1
      Related
      ENSRNOP00000088975.1, ENSRNOT00000109645.2
    2. XM_063272554.1 → XP_063128624.1  ras-related protein Rab-7b isoform X2

      UniProtKB/TrEMBL
      A0A8I6A7M1
    3. XM_008769491.4 → XP_008767713.2  ras-related protein Rab-7b isoform X1

      UniProtKB/TrEMBL
      A6IC28, A6IC29, D4A7A8
      Conserved Domains (1) summary
      cd00154
      Location:9 → 169
      Rab; Ras-related in brain (Rab) family of small guanosine triphosphatases (GTPases)
    4. XM_008769492.4 → XP_008767714.2  ras-related protein Rab-7b isoform X1

      UniProtKB/TrEMBL
      A6IC28, A6IC29, D4A7A8
      Conserved Domains (1) summary
      cd00154
      Location:9 → 169
      Rab; Ras-related in brain (Rab) family of small guanosine triphosphatases (GTPases)