Rem1 RRAD and GEM like GTPase 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Rem1provided by RGD
Official Full Name: RRAD and GEM like GTPase 1provided by RGD
Primary source: RGD:1306560
See related: EnsemblRapid:ENSRNOG00000007567 AllianceGenome:RGD:1306560
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable GTP binding activity; calcium channel regulator activity; and transmembrane transporter binding activity. Predicted to be involved in negative regulation of high voltage-gated calcium channel activity. Predicted to act upstream of or within negative regulation of calcium ion transmembrane transport via high voltage-gated calcium channel and regulation of skeletal muscle contraction by calcium ion signaling. Predicted to be located in I band and T-tubule. Predicted to be active in plasma membrane. Orthologous to human REM1 (RRAD and GEM like GTPase 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Heart (RPKM 86.3), Kidney (RPKM 49.2) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3q41

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (161563984..161572478)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (141103722..141112206)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (148108500..148116992)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The alpha(1)-adrenergic stimulation releases Rem1 inhibition of voltage-gated L-type calcium channels through direct phosphorylation of Rem1 at Ser18 by protein kinase D1, resulting in an increase of the channel activity and transverse-tubule expression.
Title: Adrenergic signaling controls RGK-dependent trafficking of cardiac voltage-gated L-type Ca2+ channels through PKD1.

Submit: New GeneRIF Correction

General gene information

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Markers

BE108637 (e-PCR)
- UniSTS:247824

RH143766 (e-PCR)
- UniSTS:233012

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables GTPase activity	IEA Inferred from Electronic Annotation more info
enables calmodulin binding	IEA Inferred from Electronic Annotation more info
enables transmembrane transporter binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within negative regulation of calcium ion transmembrane transport via high voltage-gated calcium channel	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of skeletal muscle contraction by calcium ion signaling	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in I band	ISO Inferred from Sequence Orthology more info
located_in T-tubule	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: GTP-binding protein REM 1

Names: RAS (RAD and GEM)-like GTP-binding 1; rad and gem related GTP binding protein 1

NP_001020924.1

EC 3.6.5.2

XP_006235340.1

EC 3.6.5.2

XP_038961535.1

EC 3.6.5.2

XP_038961536.1

EC 3.6.5.2

XP_063140361.1

EC 3.6.5.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001025753.2 → NP_001020924.1 GTP-binding protein REM 1

See identical proteins and their annotated locations for NP_001020924.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

UniProtKB/TrEMBL

A6KHP5, F7EX35, Q4KLY1

Conserved Domains (2) summary

smart00010
Location:81 → 245

small_GTPase; Small GTPase of the Ras superfamily; ill-defined subfamily

cd04148
Location:81 → 297

RGK; Rem, Rem2, Rad, Gem/Kir (RGK) subfamily of Ras GTPases
NM_001434435.1 → NP_001421364.1 GTP-binding protein REM 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

UniProtKB/TrEMBL

A6KHP5, F7EX35, Q4KLY1

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086021.1 Reference GRCr8

Range

161563984..161572478

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006235278.5 → XP_006235340.1 GTP-binding protein REM 1 isoform X1

Related

ENSRNOP00000010149.4, ENSRNOT00000010149.9

Conserved Domains (2) summary

smart00010
Location:81 → 245

small_GTPase; Small GTPase of the Ras superfamily; ill-defined subfamily

cd04148
Location:81 → 297

RGK; Rem, Rem2, Rad, Gem/Kir (RGK) subfamily of Ras GTPases
XM_039105607.2 → XP_038961535.1 GTP-binding protein REM 1 isoform X2

Conserved Domains (1) summary

cl38936
Location:81 → 139

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
XM_039105608.2 → XP_038961536.1 GTP-binding protein REM 1 isoform X3

Conserved Domains (1) summary

cl38936
Location:81 → 139

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
XM_063284291.1 → XP_063140361.1 GTP-binding protein REM 1 isoform X1

UniProtKB/TrEMBL

A6KHP5, F7EX35, Q4KLY1