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    Csf1 colony stimulating factor 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 78965, updated on 9-Dec-2024

    Summary

    Official Symbol
    Csf1provided by RGD
    Official Full Name
    colony stimulating factor 1provided by RGD
    Primary source
    RGD:621063
    See related
    EnsemblRapid:ENSRNOG00000018659 AllianceGenome:RGD:621063
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    PG-M-CSF
    Summary
    Enables identical protein binding activity. Involved in several processes, including cellular response to parathyroid hormone stimulus; myeloid leukocyte differentiation; and positive regulation of macrophage proliferation. Located in extracellular space. Used to study anti-basement membrane glomerulonephritis; high grade glioma; and osteopetrosis. Biomarker of systemic scleroderma. Human ortholog(s) of this gene implicated in interstitial cystitis. Orthologous to human CSF1 (colony stimulating factor 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 138.7), Lung (RPKM 62.3) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Csf1 in Genome Data Viewer
    Location:
    2q34
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (198065400..198084774, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (195377215..195396608, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (210522370..210550546, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene transfer RNA serine (anticodon AGA) 45 Neighboring gene adenosylhomocysteinase-like 1 Neighboring gene uncharacterized LOC120100914 Neighboring gene uncharacterized LOC120100915 Neighboring gene uncharacterized LOC102550122

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables cytokine activity  
    enables cytokine activity  
    enables cytokine activity  
    enables growth factor activity  
    enables growth factor activity  
    enables identical protein binding PubMed 
    enables identical protein binding  
    enables macrophage colony-stimulating factor receptor binding  
    enables protein homodimerization activity  
    enables protein homodimerization activity  
    Items 1 - 25 of 69
    Process Evidence Code Pubs
    acts_upstream_of Ras protein signal transduction  
    acts_upstream_of_or_within branching involved in mammary gland duct morphogenesis  
    involved_in cell surface receptor protein tyrosine kinase signaling pathway  
    involved_in cell surface receptor protein tyrosine kinase signaling pathway  
    involved_in cellular response to parathyroid hormone stimulus PubMed 
    involved_in developmental process involved in reproduction  
    acts_upstream_of_or_within homeostasis of number of cells within a tissue  
    involved_in inflammatory response  
    involved_in innate immune response  
    involved_in macrophage colony-stimulating factor signaling pathway  
    involved_in macrophage differentiation PubMed 
    involved_in macrophage differentiation PubMed 
    acts_upstream_of macrophage differentiation  
    acts_upstream_of_or_within macrophage homeostasis  
    acts_upstream_of_or_within mammary duct terminal end bud growth  
    acts_upstream_of_or_within mammary gland fat development  
    involved_in microglial cell proliferation  
    acts_upstream_of monocyte differentiation  
    acts_upstream_of_or_within monocyte homeostasis  
    acts_upstream_of myeloid leukocyte migration  
    acts_upstream_of_or_within neutrophil homeostasis  
    involved_in ossification PubMed 
    involved_in osteoclast differentiation  
    involved_in osteoclast differentiation  
    involved_in osteoclast differentiation PubMed 
    acts_upstream_of osteoclast differentiation  
    acts_upstream_of_or_within osteoclast differentiation  
    involved_in osteoclast differentiation  
    acts_upstream_of_or_within osteoclast proliferation  
    acts_upstream_of_or_within positive regulation of Ras protein signal transduction  
    involved_in positive regulation of cell migration PubMed 
    acts_upstream_of_or_within positive regulation of cell population proliferation  
    acts_upstream_of_or_within positive regulation of cell-matrix adhesion  
    involved_in positive regulation of gene expression  
    involved_in positive regulation of gene expression  
    acts_upstream_of_or_within positive regulation of leukocyte migration  
    involved_in positive regulation of macrophage chemotaxis  
    involved_in positive regulation of macrophage chemotaxis  
    involved_in positive regulation of macrophage colony-stimulating factor signaling pathway  
    involved_in positive regulation of macrophage colony-stimulating factor signaling pathway  
    involved_in positive regulation of macrophage derived foam cell differentiation  
    involved_in positive regulation of macrophage derived foam cell differentiation  
    involved_in positive regulation of macrophage differentiation  
    involved_in positive regulation of macrophage differentiation  
    acts_upstream_of_or_within positive regulation of macrophage differentiation  
    involved_in positive regulation of macrophage differentiation  
    involved_in positive regulation of macrophage migration  
    involved_in positive regulation of macrophage proliferation PubMed 
    involved_in positive regulation of microglial cell migration  
    involved_in positive regulation of microglial cell migration  
    acts_upstream_of_or_within positive regulation of monocyte differentiation  
    involved_in positive regulation of mononuclear cell migration PubMed 
    involved_in positive regulation of mononuclear cell proliferation  
    involved_in positive regulation of mononuclear cell proliferation  
    acts_upstream_of_or_within positive regulation of multicellular organism growth  
    acts_upstream_of_or_within positive regulation of odontogenesis of dentin-containing tooth  
    involved_in positive regulation of osteoclast differentiation  
    acts_upstream_of_or_within positive regulation of osteoclast differentiation  
    involved_in positive regulation of osteoclast differentiation  
    acts_upstream_of_or_within positive regulation of protein kinase activity  
    involved_in positive regulation of protein metabolic process  
    involved_in positive regulation of protein metabolic process  
    acts_upstream_of_or_within regulation of ossification  
    involved_in response to ischemia  
    involved_in response to ischemia  
    involved_in response to lipopolysaccharide PubMed 
    involved_in response to mechanical stimulus PubMed 
    involved_in response to organic cyclic compound PubMed 
    involved_in signal transduction  
    Items 1 - 25 of 69
    Component Evidence Code Pubs
    part_of CSF1-CSF1R complex  
    located_in extracellular region PubMed 
    is_active_in extracellular space  
    located_in extracellular space PubMed 
    located_in extracellular space  
    located_in extracellular space  
    located_in membrane  
    located_in nuclear body  
    located_in nuclear body  
    located_in perinuclear region of cytoplasm  
    located_in perinuclear region of cytoplasm  
    located_in plasma membrane  
    located_in plasma membrane  

    General protein information

    Preferred Names
    macrophage colony-stimulating factor 1
    Names
    CSF-1
    MCSF
    colony stimulating factor 1 (macrophage)
    proteoglycan macrophage colony-stimulating factor
    NP_076471.3
    XP_006233249.1
    XP_008759648.1
    XP_008759650.1
    XP_008759651.1
    XP_017446614.1
    XP_038959101.1
    XP_038959102.1
    XP_063138667.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_023981.4NP_076471.3  macrophage colony-stimulating factor 1 precursor

      See identical proteins and their annotated locations for NP_076471.3

      Status: PROVISIONAL

      Source sequence(s)
      BC074007
      UniProtKB/Swiss-Prot
      Q8JZQ0
      UniProtKB/TrEMBL
      A6HUV1, Q6GMN4
      Conserved Domains (1) summary
      pfam05337
      Location:265566
      CSF-1; Macrophage colony stimulating factor-1 (CSF-1)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      198065400..198084774 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039103173.2XP_038959101.1  macrophage colony-stimulating factor 1 isoform X5

      Conserved Domains (1) summary
      pfam05337
      Location:40206
      CSF-1; Macrophage colony stimulating factor-1 (CSF-1)
    2. XM_063282597.1XP_063138667.1  macrophage colony-stimulating factor 1 isoform X6

    3. XM_008761426.4XP_008759648.1  macrophage colony-stimulating factor 1 isoform X1

      Conserved Domains (1) summary
      pfam05337
      Location:292566
      CSF-1; Macrophage colony stimulating factor-1 (CSF-1)
    4. XM_008761428.4XP_008759650.1  macrophage colony-stimulating factor 1 isoform X2

      UniProtKB/TrEMBL
      A0A0G2K4Q6
      Related
      ENSRNOP00000097151.2, ENSRNOT00000111860.2
      Conserved Domains (1) summary
      pfam05337
      Location:265539
      CSF-1; Macrophage colony stimulating factor-1 (CSF-1)
    5. XM_039103174.2XP_038959102.1  macrophage colony-stimulating factor 1 isoform X7

      UniProtKB/TrEMBL
      A6HUV3
      Conserved Domains (1) summary
      pfam05337
      Location:40206
      CSF-1; Macrophage colony stimulating factor-1 (CSF-1)
    6. XM_017591125.3XP_017446614.1  macrophage colony-stimulating factor 1 isoform X4

      UniProtKB/Swiss-Prot
      Q8JZQ0
      UniProtKB/TrEMBL
      A0A8L2QDI9, A6HUV1
      Related
      ENSRNOP00000025221.6, ENSRNOT00000025222.8
      Conserved Domains (1) summary
      pfam05337
      Location:292593
      CSF-1; Macrophage colony stimulating factor-1 (CSF-1)
    7. XM_008761429.4XP_008759651.1  macrophage colony-stimulating factor 1 isoform X3

      UniProtKB/TrEMBL
      A0A0G2K4Q6
      Conserved Domains (1) summary
      pfam05337
      Location:292566
      CSF-1; Macrophage colony stimulating factor-1 (CSF-1)
    8. XM_006233187.4XP_006233249.1  macrophage colony-stimulating factor 1 isoform X4

      UniProtKB/Swiss-Prot
      Q8JZQ0
      UniProtKB/TrEMBL
      A0A8L2QDI9, A6HUV1
      Conserved Domains (1) summary
      pfam05337
      Location:292593
      CSF-1; Macrophage colony stimulating factor-1 (CSF-1)
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