U.S. flag

An official website of the United States government

Links from GEO Profiles

    • Showing Current items.

    Tox4 TOX high mobility group box family member 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 286990, updated on 9-Dec-2024

    Summary

    Official Symbol
    Tox4provided by RGD
    Official Full Name
    TOX high mobility group box family member 4provided by RGD
    Primary source
    RGD:708449
    See related
    EnsemblRapid:ENSRNOG00000012844 AllianceGenome:RGD:708449
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD708449
    Summary
    Predicted to enable chromatin DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in chromatin and chromosome, telomeric region. Predicted to be part of PTW/PP1 phosphatase complex. Predicted to be active in nucleus. Orthologous to human TOX4 (TOX high mobility group box family member 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 171.7), Testes (RPKM 153.6) and 9 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Tox4 in Genome Data Viewer
    Location:
    15p14
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (27462735..27476320)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (24989246..25002833)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (28696378..28709960)

    Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene RAB2B, member RAS oncogene family Neighboring gene U6 spliceosomal RNA Neighboring gene Small nucleolar RNA SNORA72 Neighboring gene methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit Neighboring gene spalt-like transcription factor 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Clone Names

    • MGC93073

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding  
    enables chromatin DNA binding  
    Component Evidence Code Pubs
    part_of PTW/PP1 phosphatase complex  
    part_of PTW/PP1 phosphatase complex  
    part_of PTW/PP1 phosphatase complex  
    located_in chromatin  
    located_in chromatin  
    located_in chromosome, telomeric region  
    located_in chromosome, telomeric region  
    is_active_in nucleus  
    located_in nucleus  

    General protein information

    Preferred Names
    TOX high mobility group box family member 4
    Names
    epidermal Langerhans cell protein LCP1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_173324.2NP_775446.2  TOX high mobility group box family member 4

      See identical proteins and their annotated locations for NP_775446.2

      Status: PROVISIONAL

      Source sequence(s)
      BC081696
      UniProtKB/Swiss-Prot
      Q99PM1
      UniProtKB/TrEMBL
      A6KEH2, F7EPW2, Q66HT2
      Related
      ENSRNOP00000017476.5, ENSRNOT00000017476.9
      Conserved Domains (3) summary
      PHA03160
      Location:464530
      PHA03160; hypothetical protein; Provisional
      COG5648
      Location:140306
      NHP6B; Chromatin-associated proteins containing the HMG domain [Chromatin structure and dynamics]
      cd00084
      Location:223288
      HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086033.1 Reference GRCr8

      Range
      27462735..27476320
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    External link. Please review our privacy policy.