Aldh5a1 aldehyde dehydrogenase 5 family, member A1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Aldh5a1provided by RGD
Official Full Name: aldehyde dehydrogenase 5 family, member A1provided by RGD
Primary source: RGD:621422
See related: EnsemblRapid:ENSRNOG00000023538 AllianceGenome:RGD:621422
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Ssadh
Summary: Enables NAD binding activity; carboxylic acid binding activity; and succinate-semialdehyde dehydrogenase (NAD+) activity. Involved in succinate metabolic process. Predicted to be located in synapse. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in succinic semialdehyde dehydrogenase deficiency. Orthologous to human ALDH5A1 (aldehyde dehydrogenase 5 family member A1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 180.7), Liver (RPKM 165.7) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 17p11

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	17	NC_086035.1 (40560373..40586711)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	17	NC_051352.1 (40132339..40158677)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	17	NC_005116.4 (42133076..42159413)

Chromosome 17 - NC_086035.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

data using R166K and R166H mutants demonstrate that inhibition of enzyme activity by low pH is regulated in part by the R166 residue. Our data indicate that the R166 residue of ALDH5A regulates multiple enzymatic functions
Title: The conserved R166 residue of ALDH5A (succinic semialdehyde dehydrogenase) has multiple functional roles.
Semialdehyde dehydrogenase [SSADH] oxidized HNE and other alpha,beta-unsaturated aldehydes. Other studies in rat brain mitochondria showed it was the predominant oxidizing enzyme for HNE but only a portion of the total activity in liver mitochondria
Title: Oxidation of 4-hydroxy-2-nonenal by succinic semialdehyde dehydrogenase (ALDH5A).

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables NAD binding	IDA Inferred from Direct Assay more info	PubMed
enables carboxylic acid binding	IPI Inferred from Physical Interaction more info	PubMed
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables succinate-semialdehyde dehydrogenase (NAD+) activity	IBA Inferred from Biological aspect of Ancestor more info
enables succinate-semialdehyde dehydrogenase (NAD+) activity	IDA Inferred from Direct Assay more info	PubMed
enables succinate-semialdehyde dehydrogenase (NAD+) activity	IEA Inferred from Electronic Annotation more info
enables succinate-semialdehyde dehydrogenase (NAD+) activity	ISO Inferred from Sequence Orthology more info
enables succinate-semialdehyde dehydrogenase (NAD+) activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in central nervous system development	IEA Inferred from Electronic Annotation more info
involved_in central nervous system development	ISO Inferred from Sequence Orthology more info
involved_in central nervous system development	ISS Inferred from Sequence or Structural Similarity more info
involved_in central nervous system development	TAS Traceable Author Statement more info	PubMed
involved_in gamma-aminobutyric acid catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in gamma-aminobutyric acid catabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within gamma-aminobutyric acid catabolic process	ISO Inferred from Sequence Orthology more info
involved_in gamma-aminobutyric acid catabolic process	ISO Inferred from Sequence Orthology more info
involved_in gamma-aminobutyric acid catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in gamma-aminobutyric acid catabolic process	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within gamma-aminobutyric acid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in glutamate metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within glutamate metabolic process	ISO Inferred from Sequence Orthology more info
involved_in post-embryonic development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within post-embryonic development	ISO Inferred from Sequence Orthology more info
involved_in succinate metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in succinate metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within succinate metabolic process	ISO Inferred from Sequence Orthology more info
involved_in synaptic transmission, GABAergic	IEA Inferred from Electronic Annotation more info
acts_upstream_of synaptic transmission, GABAergic	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISS Inferred from Sequence or Structural Similarity more info
located_in synapse	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: succinate-semialdehyde dehydrogenase, mitochondrial

Names: NAD(+)-dependent succinic semialdehyde dehydrogenase; aldehyde dehydrogenase 5 family, member A1 (succinate-semialdehyde dehydrogenase); aldehyde dehydrogenase family 5, subfamily A1; succinic semialdehyde dehydrogenase

NP_074042.1

EC 1.2.1.24

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.