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    Frrs1l ferric-chelate reductase 1-like [ Rattus norvegicus (Norway rat) ]

    Gene ID: 366376, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Frrs1lprovided by RGD
    Official Full Name
    ferric-chelate reductase 1-likeprovided by RGD
    Primary source
    RGD:1309978
    See related
    EnsemblRapid:ENSRNOG00000043103 AllianceGenome:RGD:1309978
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Epb4.1l4b
    Summary
    Predicted to enable dynein intermediate chain binding activity. Involved in regulation of postsynaptic membrane neurotransmitter receptor levels. Predicted to be located in plasma membrane. Predicted to be active in endoplasmic reticulum membrane and postsynapse. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 37. Orthologous to human FRRS1L (ferric chelate reductase 1 like). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 195.2), Spleen (RPKM 25.8) and 2 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Frrs1l in Genome Data Viewer
    Location:
    5q24
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (76451101..76485319, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (71655911..71690132, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (73997958..74029381, complement)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene catenin alpha-like 1 Neighboring gene transmembrane protein 245 Neighboring gene microRNA 32 Neighboring gene erythrocyte membrane protein band 4.1 like 4B Neighboring gene protein tyrosine phosphatase, non-receptor type 3 Neighboring gene uncharacterized LOC108350978

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. AMPA-receptor specific biogenesis complexes control synaptic transmission and intellectual ability. Brechet A, et al. Nat Commun, 2017 Jul 4. PMID 28675162, Free PMC Article
    2. Loss-of-Function Mutations in FRRS1L Lead to an Epileptic-Dyskinetic Encephalopathy. Madeo M, et al. Am J Hum Genet, 2016 Jun 2. PMID 27236917, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables dynein intermediate chain binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within regulation of AMPA glutamate receptor clustering ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of glutamate receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of glutamate receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of glutamate receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of postsynaptic membrane neurotransmitter receptor levels IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of postsynaptic membrane neurotransmitter receptor levels IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of postsynaptic membrane neurotransmitter receptor levels IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of synaptic transmission, glutamatergic ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in postsynapse ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    DOMON domain-containing protein FRRS1L
    Names
    erythrocyte protein band 4.1-like 4b
    ferric-chelate reductase 1-like protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001419637.2 → NP_001406566.1  DOMON domain-containing protein FRRS1L precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/Swiss-Prot
      D3ZE85
      Related
      ENSRNOP00000031856.4, ENSRNOT00000031432.7

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      76451101..76485319 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039111411.2 → XP_038967339.1  DOMON domain-containing protein FRRS1L isoform X1

      Conserved Domains (1) summary
      cl14783
      Location:94 → 160
      DOMON_like; Domon-like ligand-binding domains
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    D3ZE85.1 GenPept UniProtKB/Swiss-Prot:D3ZE85

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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