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    Ggps1 geranylgeranyl diphosphate synthase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 291211, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ggps1provided by RGD
    Official Full Name
    geranylgeranyl diphosphate synthase 1provided by RGD
    Primary source
    RGD:1359680
    See related
    EnsemblRapid:ENSRNOG00000016767 AllianceGenome:RGD:1359680
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Crlf3; rGGPS1a; rGGPS1a1; rGGPS1a2; rGGPS1a3
    Summary
    Predicted to enable farnesyltranstransferase activity; geranyltranstransferase activity; and identical protein binding activity. Predicted to be involved in isoprenoid biosynthetic process. Predicted to be located in several cellular components, including Z disc; nucleoplasm; and perinuclear region of cytoplasm. Orthologous to human GGPS1 (geranylgeranyl diphosphate synthase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 61.4), Spleen (RPKM 59.7) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Ggps1 in Genome Data Viewer
    Location:
    17q12.1
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (55958750..55982762)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (51263262..51282471)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (53956185..53971039)

    Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1 Neighboring gene Y-box-binding protein 1-like Neighboring gene AT-rich interaction domain 4B Neighboring gene tubulin folding cofactor E Neighboring gene beta-1,3-N-acetylgalactosaminyltransferase 2 Neighboring gene ribosomal protein S19 like 4

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables dimethylallyltranstransferase activity  
    enables farnesyltranstransferase activity  
    enables farnesyltranstransferase activity  
    enables farnesyltranstransferase activity  
    enables geranyltranstransferase activity  
    enables identical protein binding  
    enables metal ion binding  
    enables prenyltransferase activity  
    Process Evidence Code Pubs
    involved_in farnesyl diphosphate biosynthetic process  
    involved_in geranyl diphosphate biosynthetic process  
    involved_in geranylgeranyl diphosphate biosynthetic process  
    involved_in isoprenoid biosynthetic process  
    involved_in isoprenoid biosynthetic process  
    involved_in isoprenoid metabolic process  
    involved_in isoprenoid metabolic process  
    Component Evidence Code Pubs
    located_in Z disc  
    located_in Z disc  
    located_in cytoplasm  
    located_in cytoplasm  
    located_in cytosol  
    located_in cytosol  
    located_in nucleoplasm  
    located_in nucleoplasm  
    located_in perinuclear region of cytoplasm  
    located_in perinuclear region of cytoplasm  

    General protein information

    Preferred Names
    geranylgeranyl pyrophosphate synthase
    Names
    (2E,6E)-farnesyl diphosphate synthase
    GGPP synthase
    GGPP synthetase
    GGPPSase
    dimethylallyltranstransferase
    farnesyl diphosphate synthase
    farnesyltranstransferase
    geranylgeranyl pyrophosphate synthetase
    geranyltranstransferase
    NP_001007627.1
    XP_008769921.1
    XP_038951449.1
    XP_038951450.1
    XP_038951451.1
    XP_063132269.1
    XP_063132270.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001007626.4NP_001007627.1  geranylgeranyl pyrophosphate synthase

      See identical proteins and their annotated locations for NP_001007627.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000017
      UniProtKB/Swiss-Prot
      Q6F596
      Related
      ENSRNOP00000094969.2, ENSRNOT00000095806.2
      Conserved Domains (1) summary
      pfam00348
      Location:9251
      polyprenyl_synt; Polyprenyl synthetase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086035.1 Reference GRCr8

      Range
      55958750..55982762
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063276199.1XP_063132269.1  geranylgeranyl pyrophosphate synthase isoform X2

    2. XM_063276200.1XP_063132270.1  geranylgeranyl pyrophosphate synthase isoform X4

      UniProtKB/TrEMBL
      A6K9C8
    3. XM_039095523.2XP_038951451.1  geranylgeranyl pyrophosphate synthase isoform X3

      Conserved Domains (1) summary
      pfam00348
      Location:9232
      polyprenyl_synt; Polyprenyl synthetase
    4. XM_008771699.3XP_008769921.1  geranylgeranyl pyrophosphate synthase isoform X5

      See identical proteins and their annotated locations for XP_008769921.1

      Conserved Domains (1) summary
      pfam00348
      Location:1197
      polyprenyl_synt; Polyprenyl synthetase
    5. XM_039095522.2XP_038951450.1  geranylgeranyl pyrophosphate synthase isoform X1

      UniProtKB/Swiss-Prot
      Q6F596
      Conserved Domains (1) summary
      pfam00348
      Location:9251
      polyprenyl_synt; Polyprenyl synthetase
    6. XM_039095521.2XP_038951449.1  geranylgeranyl pyrophosphate synthase isoform X1

      UniProtKB/Swiss-Prot
      Q6F596
      Conserved Domains (1) summary
      pfam00348
      Location:9251
      polyprenyl_synt; Polyprenyl synthetase
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