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    Arf3 ARF GTPase 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 140940, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Arf3provided by RGD
    Official Full Name
    ARF GTPase 3provided by RGD
    Primary source
    RGD:621273
    See related
    EnsemblRapid:ENSRNOG00000054775 AllianceGenome:RGD:621273
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ac1-253
    Summary
    Predicted to enable GTP binding activity. Predicted to be involved in intracellular protein transport and retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum. Predicted to be located in Golgi apparatus. Predicted to be active in cytoplasm and plasma membrane. Orthologous to human ARF3 (ADP ribosylation factor 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 1131.6), Adrenal (RPKM 288.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Arf3 in Genome Data Viewer
    Location:
    7q36
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (131765039..131792075, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (129886082..129912022, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (140412463..140438751, complement)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene tubulin, alpha 1C Neighboring gene uncharacterized LOC103692978 Neighboring gene coiled-coil domain containing 65 Neighboring gene FKBP prolyl isomerase 11 Neighboring gene transfer RNA lysine (anticodon UUU) 3 Neighboring gene Wnt family member 10B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Interspecies relationships among ADP-ribosylation factors (ARFs): evidence of evolutionary pressure to maintain individual identities. Price SR, et al. Mol Cell Biochem, 1996 Jun 7. PMID 8813705
    2. GGA3 mediates TrkA endocytic recycling to promote sustained Akt phosphorylation and cell survival. Li X, et al. Mol Biol Cell, 2015 Dec 1. PMID 26446845, Free PMC Article
    3. WLS retrograde transport to the endoplasmic reticulum during Wnt secretion. Yu J, et al. Dev Cell, 2014 May 12. PMID 24768165
    4. Structure and intracellular localization of mouse ADP-ribosylation factors type 1 to type 6 (ARF1-ARF6). Hosaka M, et al. J Biochem, 1996 Oct. PMID 8947846
    5. Use of fluorescence-activated vesicle sorting for isolation of Naked2-associated, basolaterally targeted exocytic vesicles for proteomics analysis. Cao Z, et al. Mol Cell Proteomics, 2008 Sep. PMID 18504258, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in intracellular protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ADP-ribosylation factor 3
    Names
    liver regeneration-related protein LRRG202

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_080904.3 → NP_543180.1  ADP-ribosylation factor 3

      See identical proteins and their annotated locations for NP_543180.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/Swiss-Prot
      P61206
      UniProtKB/TrEMBL
      A0A8I5ZKF2, A6KCA5
      Related
      ENSRNOP00000069538.1, ENSRNOT00000077884.3
      Conserved Domains (1) summary
      cl38936
      Location:5 → 179
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      131765039..131792075 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017594635.3 → XP_017450124.1  ADP-ribosylation factor 3 isoform X1

      UniProtKB/Swiss-Prot
      P61206
      UniProtKB/TrEMBL
      A0A8I5ZKF2, A6KCA5
      Conserved Domains (1) summary
      cl38936
      Location:5 → 179
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    2. XM_017594636.3 → XP_017450125.1  ADP-ribosylation factor 3 isoform X1

      UniProtKB/Swiss-Prot
      P61206
      UniProtKB/TrEMBL
      A0A8I5ZKF2, A6KCA5
      Conserved Domains (1) summary
      cl38936
      Location:5 → 179
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    RNA

    1. XR_010052929.1 RNA Sequence

    2. XR_010052930.1 RNA Sequence

    3. XR_010052931.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P61206.2 GenPept UniProtKB/Swiss-Prot:P61206

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
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