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    Lats1 large tumor suppressor kinase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 308265, updated on 9-Dec-2024

    Summary

    Official Symbol
    Lats1provided by RGD
    Official Full Name
    large tumor suppressor kinase 1provided by RGD
    Primary source
    RGD:1564085
    See related
    EnsemblRapid:ENSRNOG00000014916 AllianceGenome:RGD:1564085
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1564085
    Summary
    Predicted to enable several functions, including ATP binding activity; magnesium ion binding activity; and nuclear estrogen receptor binding activity. Involved in regulation of postsynaptic density assembly. Is active in glutamatergic synapse and postsynapse. Orthologous to human LATS1 (large tumor suppressor kinase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 139.6), Lung (RPKM 126.3) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Lats1 in Genome Data Viewer
    Location:
    1p13
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (3980801..4014029)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (2160411..2193640)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (1784078..1817310)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120098770 Neighboring gene LDL receptor related protein 11 Neighboring gene protein-L-isoaspartate (D-aspartate) O-methyltransferase 1 Neighboring gene nucleoporin 43 Neighboring gene small ribosomal subunit protein uS12-like Neighboring gene katanin catalytic subunit A1 Neighboring gene HN1-like pseudogene

    Genomic regions, transcripts, and products

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables magnesium ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables nuclear estrogen receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in G1/S transition of mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in G2/M transition of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cytoplasmic sequestering of protein ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in hippo signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within hippo signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in hippo signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in hormone-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within inner cell mass cell fate commitment ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within inner cell mass cellular morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within keratinocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mammary gland epithelial cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cyclin-dependent protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of protein localization to nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of NLRP3 inflammasome complex assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of peptidyl-serine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within protein localization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of actin filament polymerization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of intracellular estrogen receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of organ growth IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of postsynaptic density assembly EXP
    Inferred from Experiment
    more info
    PubMed 
    involved_in regulation of postsynaptic density assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of postsynaptic density assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of protein-containing complex assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of transforming growth factor beta receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in sister chromatid segregation ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in glutamatergic synapse EXP
    Inferred from Experiment
    more info
    PubMed 
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    is_active_in postsynapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in postsynapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    is_active_in spindle pole IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in spindle pole ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    serine/threonine-protein kinase LATS1
    Names
    LATS, large tumor suppressor, homolog 1
    NP_001128015.2
    XP_038966819.1
    XP_038966822.1
    XP_063144688.1
    XP_063144691.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001134543.2NP_001128015.2  serine/threonine-protein kinase LATS1

      See identical proteins and their annotated locations for NP_001128015.2

      Status: VALIDATED

      Source sequence(s)
      FN804841, JAXUCZ010000001
      UniProtKB/TrEMBL
      F1M2K4
      Related
      ENSRNOP00000020098.6, ENSRNOT00000020098.9
      Conserved Domains (3) summary
      PHA03247
      Location:183590
      PHA03247; large tegument protein UL36; Provisional
      cd05625
      Location:7031084
      STKc_LATS1; Catalytic domain of the Serine/Threonine Kinase, Large Tumor Suppressor 1
      cl21463
      Location:103143
      UBA_like_SF; UBA domain-like superfamily

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      3980801..4014029
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039110894.1XP_038966822.1  serine/threonine-protein kinase LATS1 isoform X2

      Related
      ENSRNOP00000101033.1, ENSRNOT00000123353.1
      Conserved Domains (3) summary
      PHA03247
      Location:66473
      PHA03247; large tegument protein UL36; Provisional
      cd05625
      Location:586967
      STKc_LATS1; Catalytic domain of the Serine/Threonine Kinase, Large Tumor Suppressor 1
      cl21463
      Location:126
      UBA_like_SF; UBA domain-like superfamily
    2. XM_063288618.1XP_063144688.1  serine/threonine-protein kinase LATS1 isoform X1

      UniProtKB/TrEMBL
      F1M2K4
    3. XM_063288621.1XP_063144691.1  serine/threonine-protein kinase LATS1 isoform X3

    4. XM_039110891.2XP_038966819.1  serine/threonine-protein kinase LATS1 isoform X1

      UniProtKB/TrEMBL
      F1M2K4
      Conserved Domains (3) summary
      PHA03247
      Location:183590
      PHA03247; large tegument protein UL36; Provisional
      cd05625
      Location:7031084
      STKc_LATS1; Catalytic domain of the Serine/Threonine Kinase, Large Tumor Suppressor 1
      cl21463
      Location:103143
      UBA_like_SF; UBA domain-like superfamily