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    Ggn gametogenetin [ Rattus norvegicus (Norway rat) ]

    Gene ID: 292765, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ggnprovided by RGD
    Official Full Name
    gametogenetinprovided by RGD
    Primary source
    RGD:1306765
    See related
    EnsemblRapid:ENSRNOG00000023931 AllianceGenome:RGD:1306765
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable identical protein binding activity and ubiquitin protein ligase binding activity. Predicted to be involved in gamete generation. Predicted to act upstream of or within double-strand break repair; embryo implantation; and protein localization. Predicted to be located in perinuclear region of cytoplasm. Human ortholog(s) of this gene implicated in spermatogenic failure 69. Orthologous to human GGN (gametogenetin). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 65.5), Kidney (RPKM 13.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ggn in Genome Data Viewer
    Location:
    1q21
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (93598076..93601598)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (84470488..84474120)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (88112873..88116990)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene MARCKS-related protein-like Neighboring gene large ribosomal subunit protein eL27-like Neighboring gene RAS guanyl releasing protein 4 Neighboring gene family with sequence similarity 98, member C Neighboring gene sprouty-related, EVH1 domain containing 3 Neighboring gene proteasome 26S subunit, non-ATPase 8

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Relapsing polychondritis, induced in mice with matrilin 1, is an antibody- and complement-dependent disease. Hansson AS, et al. Am J Pathol, 2004 Mar. PMID 14982849, Free PMC Article
    2. Mouse GGN1 and GGN3, two germ cell-specific proteins from the single gene Ggn, interact with mouse POG and play a role in spermatogenesis. Lu B, et al. J Biol Chem, 2003 May 2. PMID 12574169
    3. Loss of GGN leads to pre-implantation embryonic lethality and compromised male meiotic DNA double strand break repair in the mouse. Jamsai D, et al. PLoS One, 2013. PMID 23451117, Free PMC Article
    4. Yeast two-hybrid screens imply that GGNBP1, GGNBP2 and OAZ3 are potential interaction partners of testicular germ cell-specific protein GGN1. Zhang J, et al. FEBS Lett, 2005 Jan 17. PMID 15642376
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin protein ligase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in double-strand break repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within double-strand break repair ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within embryo implantation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in gamete generation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in gamete generation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within protein localization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in spermatogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    gametogenetin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013065.1 → NP_001013083.2  gametogenetin isoform 1

      See identical proteins and their annotated locations for NP_001013083.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer tanscript and encodes the longer isoform (1).
      Source sequence(s)
      BC081922
      UniProtKB/TrEMBL
      A0A8I5ZK25, A0A8L2QQF7
      Related
      ENSRNOP00000053791.4, ENSRNOT00000056955.4
      Conserved Domains (1) summary
      pfam15685
      Location:38 → 693
      GGN; Gametogenetin

    2. NM_001309827.1 → NP_001296756.1  gametogenetin isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' structure, resulting in the use of an alternate start codon compared to variant 1. The encoded isoform (2) has a distinct N-terminus, and is shorter than isoform 1.
      Source sequence(s)
      BC100147
      UniProtKB/TrEMBL
      A0A8I5ZK25, A0A8I5ZZG9
      Conserved Domains (1) summary
      pfam15685
      Location:15 → 670
      GGN; Gametogenetin

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      93598076..93601598
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006228719.5 → XP_006228781.1  gametogenetin isoform X1

      See identical proteins and their annotated locations for XP_006228781.1

      UniProtKB/Swiss-Prot
      Q66HC8
      UniProtKB/TrEMBL
      A0A8I5ZK25
      Conserved Domains (1) summary
      pfam15685
      Location:2 → 657
      GGN; Gametogenetin
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q66HC8.1 GenPept UniProtKB/Swiss-Prot:Q66HC8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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