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    Isoc2b isochorismatase domain containing 2b [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361501, updated on 4-Jan-2025

    Summary

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    Official Symbol
    Isoc2bprovided by RGD
    Official Full Name
    isochorismatase domain containing 2bprovided by RGD
    Primary source
    RGD:1309062
    See related
    EnsemblRapid:ENSRNOG00000016829 AllianceGenome:RGD:1309062
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Isoc2; RGD1309062
    Summary
    Predicted to be involved in protein destabilization. Predicted to be located in mitochondrion and nucleus. Predicted to be active in cytoplasm. Orthologous to human ISOC2 (isochorismatase domain containing 2). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in Heart (RPKM 252.4), Liver (RPKM 143.6) and 9 other tissues See more
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    Genomic context

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    See Isoc2b in Genome Data Viewer
    Location:
    1q12
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (78001735..78022565)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (68972960..68993760)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (72524569..72545331)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene isochorismatase domain containing 2A Neighboring gene ATPase H+ transporting V0 subunit C, pseudogene 2 Neighboring gene shisa family member 7 Neighboring gene uncharacterized LOC134482885

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Identification and characterization of a novel protein ISOC2 that interacts with p16INK4a. Huang X, et al. Biochem Biophys Res Commun, 2007 Sep 21. PMID 17658461
    2. Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context. Morgenstern M, et al. Cell Metab, 2021 Dec 7. PMID 34800366, Free PMC Article
    3. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC105521

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in protein destabilization ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    isochorismatase domain-containing protein 2
    Names
    isochorismatase domain containing 2
    isochorismatase domain-containing protein 2, mitochondrial

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001008367.1 → NP_001008368.1  isochorismatase domain-containing protein 2

      Status: PROVISIONAL

      Source sequence(s)
      BC085336
      UniProtKB/Swiss-Prot
      Q5U3Z3
      UniProtKB/TrEMBL
      A0A8L2QD03, A6KNP7
      Related
      ENSRNOP00000066553.3, ENSRNOT00000071971.4
      Conserved Domains (1) summary
      cd01012
      Location:18 → 170
      YcaC_related; YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them. ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      78001735..78022565
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063266269.1 → XP_063122339.1  isochorismatase domain-containing protein 2 isoform X5

      Related
      ENSRNOP00000105164.1, ENSRNOT00000148934.1

    2. XM_063266283.1 → XP_063122353.1  isochorismatase domain-containing protein 2 isoform X6

    3. XM_063266268.1 → XP_063122338.1  isochorismatase domain-containing protein 2 isoform X4

    4. XM_063266265.1 → XP_063122335.1  isochorismatase domain-containing protein 2 isoform X2

      UniProtKB/TrEMBL
      A6KNP9

    5. XM_063266267.1 → XP_063122337.1  isochorismatase domain-containing protein 2 isoform X3

      UniProtKB/TrEMBL
      A6KNP9

    6. XM_063266264.1 → XP_063122334.1  isochorismatase domain-containing protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A8L2QD03
      Related
      ENSRNOP00000022621.5, ENSRNOT00000022620.5

    RNA

    1. XR_010054069.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5U3Z3.1 GenPept UniProtKB/Swiss-Prot:Q5U3Z3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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