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    Hsd11b2 hydroxysteroid 11-beta dehydrogenase 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25117, updated on 9-Dec-2024

    Summary

    Official Symbol
    Hsd11b2provided by RGD
    Official Full Name
    hydroxysteroid 11-beta dehydrogenase 2provided by RGD
    Primary source
    RGD:2835
    See related
    EnsemblRapid:ENSRNOG00000017084 AllianceGenome:RGD:2835
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables NAD binding activity and steroid binding activity. Involved in several processes, including glucocorticoid metabolic process; regulation of blood volume by renal aldosterone; and response to insulin. Predicted to be located in endoplasmic reticulum. Predicted to be active in intracellular membrane-bounded organelle. Used to study hypertension. Biomarker of fetal alcohol spectrum disorder; hypertension; myocardial infarction; obesity; and ureteral obstruction. Human ortholog(s) of this gene implicated in apparent mineralocorticoid excess syndrome; hypertension; inherited metabolic disorder; obesity; and type 1 diabetes mellitus. Orthologous to human HSD11B2 (hydroxysteroid 11-beta dehydrogenase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 337.0), Adrenal (RPKM 128.0) and 2 other tissues See more
    Orthologs
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    Genomic context

    See Hsd11b2 in Genome Data Viewer
    Location:
    19q12
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (50307569..50312812)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (33397656..33402899)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (37476083..37481326)

    Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene tubulin polymerization-promoting protein family member 3 Neighboring gene zinc finger, DHHC-type containing 1 Neighboring gene ATPase H+ transporting V0 subunit D1 Neighboring gene uncharacterized LOC134483348 Neighboring gene small nuclear ribonucleoprotein E-like Neighboring gene agouti related neuropeptide

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Clone Names

    • MGC93528

    Gene Ontology Provided by RGD

    Component Evidence Code Pubs
    located_in endoplasmic reticulum  
    is_active_in intracellular membrane-bounded organelle  
    located_in intracellular membrane-bounded organelle  

    General protein information

    Preferred Names
    11-beta-hydroxysteroid dehydrogenase type 2
    Names
    11-DH2
    11-beta-HSD2
    Hydroxysteroid dehydrogenase, 11 beta type 2
    NAD-dependent 11-beta-hydroxysteroid dehydrogenase
    corticosteroid 11-beta-dehydrogenase isozyme 2
    NP_058777.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_017081.2NP_058777.1  11-beta-hydroxysteroid dehydrogenase type 2

      See identical proteins and their annotated locations for NP_058777.1

      Status: PROVISIONAL

      Source sequence(s)
      U22424
      UniProtKB/Swiss-Prot
      P50233
      UniProtKB/TrEMBL
      A6IYQ2
      Related
      ENSRNOP00000023130.1, ENSRNOT00000023130.5
      Conserved Domains (1) summary
      cd09805
      Location:83363
      type2_17beta_HSD-like_SDR_c; human 17beta-hydroxysteroid dehydrogenase type 2 (type 2 17beta-HSD)-like, classical (c) SDRs

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086037.1 Reference GRCr8

      Range
      50307569..50312812
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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