Psmd9 proteasome 26S subunit, non-ATPase 9 [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Psmd9provided by RGD
Full Name: proteasome 26S subunit, non-ATPase 9provided by RGD
Primary source: RGD:621110
See related: EnsemblRapid:ENSRNOG00000077689 AllianceGenome:RGD:621110
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Bridge; Bridge-1
Summary: Enables bHLH transcription factor binding activity and transcription coactivator activity. Involved in positive regulation of transcription by RNA polymerase II; regulation of insulin secretion; and type B pancreatic cell apoptotic process. Located in nucleus. Orthologous to human PSMD9 (proteasome 26S subunit, non-ATPase 9). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Liver (RPKM 128.1), Adrenal (RPKM 89.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 12q16

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	12	NC_086030.1 (38998027..39018340, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	12	NC_051347.1 (33337182..33357468, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	12	NC_005111.4 (38786539..38805121, complement)

Chromosome 12 - NC_086030.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Bridge-1 is expressed in human granulosa cells and can be stimulated by activin A, an important factor for follicle maturation.
Title: Bridge-1 is expressed in human granulosa cells and is involved in the activin A signaling cascade.
Signals mediated through the coactivator Bridge-1 may regulate both glucose homeostasis and pancreatic beta-cell survival, and coactivator dysfunction in pancreatic beta-cells can limit insulin production and contribute to the pathogenesis of diabetes.
Title: Overexpression of the coactivator bridge-1 results in insulin deficiency and diabetes.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

BI276461 (e-PCR)
- UniSTS:249866

RH139716 (e-PCR)
- UniSTS:221800

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables bHLH transcription factor binding	IDA Inferred from Direct Assay more info	PubMed
enables bHLH transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription coactivator activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in negative regulation of insulin secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of insulin secretion	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in proteasome regulatory particle assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteasome regulatory particle assembly	ISO Inferred from Sequence Orthology more info
involved_in proteasome regulatory particle assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in type B pancreatic cell apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
part_of proteasome regulatory particle, base subcomplex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: 26S proteasome non-ATPase regulatory subunit 9

Names: 26S proteasome non-ATPase regulatory subunit 9-like; 26S proteasome regulatory subunit p27; proteasome (prosome, macropain) 26S subunit, non-ATPase, 9; transactivating protein Bridge-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_130430.2 → NP_569114.2 26S proteasome non-ATPase regulatory subunit 9

Status: VALIDATED

Source sequence(s)

JAXUCZ010000012

UniProtKB/Swiss-Prot

Q9WTV5

UniProtKB/TrEMBL

A6J160

Related

ENSRNOP00000109118.1, ENSRNOT00000140737.1

Conserved Domains (2) summary

cd00989
Location:132 → 204

PDZ_metalloprotease; PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ ...

pfam18265
Location:23 → 102

Nas2_N; Nas2 N_terminal domain